Elucidating Signal Transduction Modulatory Drug Target Network of Colon Cancer: A Network Biology Approach

Latest evaluation and validation of cancer drugs and their targets has demonstrated the lack and inadequate development of new and better drugs, based on available protocols. Even though the specificity of drug targets is a great challenge in the pharmaco-proteomics field of cancer biology, for eradicating such hurdles and paving the way for the drugs of future, a novel step has been envisaged here to study the relation between drug target network and the corresponding drug network using the advanced concepts of proteomics and network biology. The literature mining was done for the collection of receptors and the ligands. About 1000 natural compounds were collected and out of those 300 molecules showed anti-cancer activity against colon cancer. Ligand Vs multiple receptor docking was done using the software Quantum 3.3.0; the results were further used for the designing of a well connected Protein Ligand Interaction (PLI) network of colon cancer. The obtained network is then extrapolated to sort out the receptors expressed in the specific cancer type. The network is then statistically analyzed and represented by the graphical interpretation, in order to ascertain the hub nodes and their locally parsed neighbours. Based on the best docking scores, the graphs obtained from the docking analysis are statistically validated with the help of VisANT. In the network three hub nodes Neutrophil cytosol factor 2, UV excision repair protein RAD23 homolog A, & Receptor-type tyrosine-protein phosphatase eta were identified, which showed the highest interaction with the ligands. Butyrate and Farnesol showed highest interaction as ligands. Multiple Sequence Alignment was done of the binding site sequence of the drug targets to find out the evolutionary closeness of the binding sites. The phylogenetic tree was also constructed to further validate the observation. Further in-vitro and in-vivo studies needs to be done to analyse the receptor specificity and anti tumor activity of these compounds in Colon cancer

Three Dimensional Gait Assessment During Walking of Healthy People and Drop Foot Patients

The aim of the present study is to clinical gait analysis of normal human and drop foot patients. Gait analysis is the systematic study of animal locomotion, more specifically the study of human motion, using the eye and the brain of observers, augmented by instrumentation for measuring body movements, body mechanics, and the activity of the muscles. Gait analysis is used to assess, plan, and treat individuals with conditions affecting their ability to walk. Foot drop is a deceptively simple name for a potentially complex problem. It can be defined as a significant weakness of ankle and toe dorsiflexion. The foot and ankle dorsiflexors include the tibialis anterior, the extensor hallucis longus (EHL), and the extensor digitorum longus (EDL). These muscles help the body clear the foot during the swing phase and control plantar flexion of the foot at heel strik

Asymmetric Squares as Standing Waves in Rayleigh-Benard Convection

Possibility of asymmetric square convection is investigated numerically using a few mode Lorenz-like model for thermal convection in Boussinesq fluids confined between two stress free and conducting flat boundaries. For relatively large value of Rayleigh number, the stationary rolls become unstable and asymmetric squares appear as standing waves at the onset of secondary instability. Asymmetric squares, two dimensional rolls and again asymmetric squares with their corners shifted by half a wavelength form a stable limit cycle.Comment: 8 pages, 7 figure

Wavy stripes and squares in zero P number convection

A simple model to explain numerically observed behaviour of chaotically varying stripes and square patterns in zero Prandtl number convection in Boussinesq fluid is presented. The nonlinear interaction of mutually perpendicular sets of wavy rolls, via higher mode, may lead to a competition between the two sets of wavy rolls. The appearance of square patterns is due to the secondary forward Hopf bifurcation of a set of wavy rolls.Comment: 8 pages and 3 figures, late

Temperature-time dependent transmittance, sheet resistance and bonding energy of reduced graphene oxide on soda lime glass.

Reduced graphene oxide coated soda lime glass can act as an alternative transparent/conducting electrode for many opto-electronic applications. However, bonding between the deposited reduced graphene oxide film and the glass substrate is important for achieving better stability of the coating and an extended device lifetime. In the present study, delamination energy of reduced graphene oxide on soda lime glass was quantified by using nanoscratch technique. Graphene oxide was deposited on soda lime glass by dip coating technique and was thermally reduced at different temperatures (100 °C, 200 °C, 300 °C, 400 °C and 500 °C) and treatment time (2 h, 3 h, 4 h, 5 h and 10 h) in Ar (95%) with H2 (5%) atmosphere. An inverse behavior of delamination energy with temperature and treatment time was observed, which could be correlated with the removal of oxygen functional groups. Sheet resistance of the film demonstrated a steady decay with increasing temperature and treatment time. Functional groups attached to the graphene planes have more influence on conductivity than groups attached to the edges. Removal of functional groups could also be related to optical transmittance of the samples. Knowledge generated in this study with respect to delamination energy, sheet resistance and optical transmittance could be extensively used for various opto-electronic applications

Optical Dispersion In Annealed Thin Films of S-doped a-Si:H Alloys

S-doped amorphous hydrogenated silicon (a-Si,S:H) thin films were prepared by conventional PECVD method on corning glass substrates. The prepared thin films were subsequently annealed in vacuum (~ 2 × 10 – 6 Torr) in the temperature range from 100 °C to 500 °C. The annealing effects at room temperature were examined by means of optical transmission spectra of the films in the wavelength range 300-1100 nm. Dispersion in optical constants such as transmittance, bandgap and refractive index were observed. Tailoring in optical constants was observed with respect to doping concentrations as well as the annealing temperatures. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/3097

A State-of-the-Art review on the drive of renewables in Gujarat, State of India: Present situation, barriers and future initiatives

Given the recent increasing public focus on climate change issues, the share of electricity generation by renewable energy resources is increasing day by day. Increased renewables share will give us robust, sustainable, and climate-friendly energy systems for the future. Renewable energy penetration with the current power systems needs substantial research, planning and development which are now the primary focus throughout the world. In this study, a global renewable energy scenario is explained in detail in contrast with India, considering a case study elucidating the comprehensive review of the Gujarat state in India. The primary focus is on Gujarat state’s actions plans to pertain to harvest renewable energy and maximizing its share in the energy mix. This study examines the actions and the policies adopted by the Gujarat government to overcome the potential barriers in order to support non-conventional as well as renewable energy development. It also investigates the numerous techno-economic and social constraints with possible solutions in promoting the deployment of upcoming renewable energy resources across Gujarat. This study can be used as a guideline for the government, policymakers, utilities, stakeholders and researchers to promote an increased renewable energy share in Gujarat as well as at other places around the globe

Hybrid renewable energy microgrid for a residential community: A techno-economic and environmental perspective in the context of the SDG7

Energy, being a prime enabler in achieving sustainable development goals (SDGs), should be affordable, reliable, sustainable, and modern. One of the SDGs (i.e., SDG7) suggests that it is necessary to ensure energy access for all. In developing countries like India, the progress toward SDG7 has somewhat stagnated. The aging conventional electric power system has its dominant share of energy from fossil fuels, plagued with frequent power outages, and leaves many un-electrified areas. These are not characteristics of a sustainable and modern system in the context of the SDG7. Promoting renewable-based energy systems, especially in the context of microgrids (MGs), is one of the promising advances needed to rejuvenate the progress toward the SDG7. In this context, a hybrid renewable energy microgrid (HREM) is proposed that gives assurance for energy access to all in an affordable, reliable, and sustainable way through modern energy systems. In this paper, a techno-economic and environmental modeling of the grid-independent HREM and its optimization for a remote community in South India are presented. A case of HREM with a proposed configuration of photovoltaic/wind turbine/diesel generator/battery energy storage system (PV/WT/DG/BESS) was modeled to meet the community residential electric load requirements. This investigation dealt with the optimum sizes of the different components used in the HREM. The results of this model presented numerous feasible solutions. Sensitivity analysis was conducted to identify the best solution from the four optimized results. From the results, it was established that a PV + DG + BESS based HREM was the most cost-effective configuration for the specific location. In addition, the obtained optimum solutions were mapped with the key criteria of the SDG7. This mapping also suggested that the PV + DG + BESS configuration falls within the context of the SDG7. Overall, it is understood that the proposed HREM would provide energy access to households that is affordable, reliable, sustainable, and modern

Effective Values of Komar Conserved Quantities and Their Applications

We calculate the effective Komar angular momentum for the Kerr-Newman (KN) black hole. This result is valid at any radial distance on and outside the black hole event horizon. The effcetive values of mass and angular momentum are then used to derive an identity ($K_{\chi^{\mu}}=2ST$) which relates the Komar conserved charge ($K_{\chi^{\mu}}$) corresponding to the null Killing vector ($\chi^{\mu}$) with the thermodynamic quantities of this black hole. As an application of this identity the generalised Smarr formula for this black hole is derived. This establishes the fact that the above identity is a local form of the inherently non-local generalised Smarr formula.Comment: v3, minor modifications over v2; LaTex, 9 pages, no figures, to appear in Int. Jour. Theo. Phy