119 research outputs found
Intrapleural hypotonic cisplatin treatment for malignant pleural effusion in 80 patients with non-small-cell lung cancer: a multi-institutional phase II trial
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- Publication venue
- Publication date
- Field of study
To assess the effect and toxicity of hypotonic cisplatin treatment (HPT) consisting of the intrapleural administration of cisplatin in distilled water for malignant pleural effusion in patients with non-small-cell lung cancer (NSCLC). Non-small-cell lung cancer patients with cytologically proven and previously untreated malignant pleural effusion were enrolled into this study. Firstly, the lung was fully re-expanded by a tube thoracostomy, and then 25 mg cisplatin in 500 ml of distilled water was instilled through a chest tube and then the tube was clamped. After 1 h, the tube was declamped and allowed to drain. The chest tube was removed when the pleural effusion volume decreased to 200 ml or less per day. A complete response (CR) was considered to occur when the pleural effusion disappeared. A partial response (PR) was determined to occur when the volume of pleural effusion remained under ¼ of hemithorax. The response at 4 weeks was evaluated by an extramural review. Out of 84 patients enrolled from February 1998 to August 2002, 80 patients were eligible and analysed in the present study. The toxicity of HPT was acceptable. Neither a haematological toxicity of any grade nor grade 4 nonhaematological toxicity was observed. Grade 3 nonhaematological toxicities were observed, including nausea (4%), vomiting (3%), pyothorax (1%) and dyspnoea (1%). The median time of drainage from HTP was 4 days. Twenty-seven (34%) and 39 (49%) patients achieved CR and PR, respectively, for an overall response rate of 83% (95% confidence interval, 74–91%). The median duration of the response was 206 days. The median survival time of all patients was 239 days. Hypotonic cisplatin treatment for malignant pleural effusion of NSCLC is therefore considered to be feasible and effective. A phase III study of HPT is thus warranted
Low BMD affects initial stability and delays stem osseointegration in cementless total hip arthroplasty in women: A 2-year RSA study of 39 patients
- Author
- Alm JJ
- Aspenberg P
- Bottner F
- Campbell D
- Davidson D
- Dorr LD
- Gabet Y
- Glowacki J
- Grant P
- Hailer NP
- Hannu T Aro
- Hartman CW
- Jessica J Alm
- Kaptein BL
- Keisu KS
- Kelly SJ
- Kärrholm J
- Kärrholm J
- Kärrholm J
- Meding JB
- Moritz N
- Muirhead-Allwood S
- Mäkelä KT
- Mäkinen TJ
- Mäkinen TJ
- Niko Moritz
- Noble PC
- Omlor GW
- Petteri Lankinen
- Pilliar RM
- Ström H
- Søballe K
- Tatu J Mäkinen
- Thien TM
- Thillemann TM
- van der Wal BC
- van Rietbergen B
- Publication venue
- Informa Healthcare
- Publication date
- Field of study
Farnesoid X Receptor Induces Murine Scavenger Receptor Class B Type I via Intron Binding
- Author
- A Al-Jarallah
- A Mencarelli
- AM Thomas
- Ann M. Thomas
- Antonio Moschetta
- B Flatt
- Bo Kong
- CJ Sinal
- D Lopez
- F Chao
- G Lambert
- G Li
- Grace L. Guo
- Guodong Li
- H Gao
- HB Hartman
- HK Chong
- I Pineda Torra
- Jessica A. Williams
- Jie Liu
- JS Teodoro
- JW Nicol
- K Schoonjans
- KF Kozarsky
- KT Landschulz
- L Malerod
- L Malerod
- L Malerod
- M Fuchs
- M Krieger
- M Van Eck
- MS Hamza
- N Wang
- NY Kalaany
- P Mardones
- PJ Farnham
- PJ Park
- RA Ahmed
- RD Hawkins
- RM Gadaleta
- S Acton
- S Han
- SL Acton
- T Kok
- Wen Xie
- Y Tanaka
- Y Ueda
- Y Zhang
- Y Zhang
- Y Zhu
- Yuka Inaba
- Publication venue
- Public Library of Science
- Publication date
- 23/04/2012
- Field of study
Farnesoid X receptor (FXR) is a nuclear receptor and a key regulator of liver cholesterol and triglyceride homeostasis. Scavenger receptor class B type I (SR-BI) is critical for reverse cholesterol transport (RCT) by transporting high-density lipoprotein (HDL) into liver. FXR induces SR-BI, however, the underlying molecular mechanism of this induction is not known. The current study confirmed induction of SR-BI mRNA by activated FXR in mouse livers, a human hepatoma cell line, and primary human hepatocytes. Genome-wide FXR binding analysis in mouse livers identified 4 putative FXR response elements in the form of inverse repeat separated by one nucleotide (IR1) at the first intron and 1 IR1 at the downstream of the mouse Sr-bi gene. ChIP-qPCR analysis revealed FXR binding to only the intronic IR1s, but not the downstream one. Luciferase assays and site-directed mutagenesis further showed that 3 out of 4 IR1s were able to activate gene transcription. A 16-week high-fat diet (HFD) feeding in mice increased hepatic Sr-bi gene expression in a FXR-dependent manner. In addition, FXR bound to the 3 bona fide IR1s in vivo, which was increased following HFD feeding. Serum total and HDL cholesterol levels were increased in FXR knockout mice fed the HFD, compared to wild-type mice. In conclusion, the Sr-bi/SR-BI gene is confirmed as a FXR target gene in both mice and humans, and at least in mice, induction of Sr-bi by FXR is via binding to intronic IR1s. This study suggests that FXR may serve as a promising molecular target for increasing reverse cholesterol transport
Neoadjuvant treatment of pancreatic adenocarcinoma: a systematic review and meta-analysis of 5520 patients
- Author
- A Andriulli
- A Barbour
- A Jesus-Acosta De
- A Mahadevan
- A Paniccia
- A Wang-Gillam
- AD Parmar
- AP Gulati
- BA Boone
- C Cassinotto
- C Hajj
- C Milandri
- C RFd
- C Tinchon
- CB Begg
- Chandrakanth Are
- CM Kang
- CR Ferrone
- CW Tzeng
- CW Tzeng
- D Habermehl
- D Moher
- D Schellenberg
- D Tinkl
- Davendra P.S. Sohal
- DB Evans
- DB Evans
- DB Evans
- DD Hoff Von
- DJ Hartman
- DP Sohal
- DW Maximous
- E Sadot
- EH Jensen
- Eileen M. O’Reilly
- EJ Kim
- EM O'Reilly
- ES James
- ES Rosmarakis
- F Bednar
- F Leone
- F Motoi
- F Polistina
- G Barugola
- Gautam K. Malhotra
- GC Mattiucci
- GR Varadhachary
- GR Varadhachary
- H Eguchi
- H Golcher
- H Mahaseth
- H Oettle
- H Tajima
- H Tajima
- H Takahashi
- HA Burris 3rd
- I Epelboym
- IR Cho
- IT Konstantinidis
- J Fatima
- J He
- J Landry
- JB Rose
- JB Stokes
- JE Faris
- JK Bjerregaard
- JL Lee
- JM Herman
- JM Herman
- JM Winter
- JP Neoptolemos
- JP Neoptolemos
- JY Wo
- K Sahora
- K Sahora
- K Sahora
- KA Bickenbach
- KC Conlon
- KC Cuneo
- KD Miller
- KK Christians
- KS Gunturu
- KT Chen
- KT Papalezova
- L Marthey
- Lynette M. Smith
- M Alagappan
- M Alline
- M Blazer
- M Chllamma
- M Egger
- M Kobayashi
- M Mizuma
- M Patel
- M Shinoto
- M Sho
- M Suker
- MA Tempero
- Mashaal Dhir
- MD Chuong
- MH Katz
- MH Katz
- MK Gurka
- MM Assifi
- MM Corsini
- MP Callery
- MS Rajagopalan
- Nathan Bahary
- ND Arvold
- NF Esnaola
- Nicholas A. Hein
- O Turrini
- OM Rashid
- PF Peddi
- PJ Hosein
- PJ Loehrer Sr
- R Alvarez
- R Kapoor
- R Scodan Le
- R Wilkowski
- RA Abrams
- RJ McClaine
- RL Araujo
- RL Siegel
- RM Minter
- S Chakraborty
- S Gillen
- S Satoi
- S Tsai
- SE Combs
- T Conroy
- T Ioka
- TS Hong
- V Cetin
- VN Nyaga
- W Small Jr
- WF Regine
- WH Sherman
- Y Takeda
- Y Tomimaru
- Y-J Chao
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Dijet Resonance Search with Weak Supervision Using root S=13 TeV pp Collisions in the ATLAS Detector
- Author
- Aad G
- Abbott B
- Abbott DC
- Abeling K
- Abhayasinghe DK
- Abidi SH
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abud AA
- Abulaiti Y
- Acharya BS
- Achkar B
- Adam L
- Adamczyk L
- Adamek L
- Adelman J
- Adersberger M
- Adiguzel A
- Adorni S
- Adye T
- Affolder AA
- Afik Y
- Agapopoulou C
- Agaras MN
- Aggarwal A
- Agheorghiesei C
- Aguilar-Saavedra JA
- Ahmad A
- Ahmadov F
- Ahmed WS
- Ai X
- Aielli G
- Akatsuka S
- Akesson TPA
- Akilli E
- Akimov A
- Al Khoury K
- Alberghi GL
- Albert J
- Alderweireldt S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexopoulos T
- Alfonsi A
- Alfonsi F
- Alhroob M
- Ali B
- Ali S
- Aliev M
- Alimonti G
- Allaire C
- Allbrooke BMM
- Allen BW
- Allport PP
- Aloisio A
- Alonso F
- Alpigiani C
- Alshehri AA
- Alvarez Estevez M
- Alviggi MG
- Amaral Coutinho Y
- Ambler A
- Ambroz L
- Amelung C
- Amidei D
- Amor Dos Santos SP
- Amoroso S
- Amrouche CS
- An F
- Anastopoulos C
- Andari N
- Andeen T
- Anders CF
- Anders JK
- Andrean SY
- Andreazza A
- Andrei V
- Anelli CR
- Angelidakis S
- Angerami A
- Anisenkov A
- Annovi A
- Antel C
- Anthony MT
- Antipov E
- Antonelli M
- Antrim DJA
- Anulli F
- Aoki M
- Aparisi Pozo JA
- Aparo MA
- Aperio Bella L
- Araujo Ferraz V
- Araujo Pereira R
- Araya ST
- Arcangeletti C
- Arce ATH
- Arduh FA
- Arguin J-F
- Argyropoulos S
- Arling J-H
- Armbruster AJ
- Armstrong A
- Arnaez O
- Arnold H
- Artoni G
- Artz S
- Asai S
- Asawatavonvanich T
- Asbah N
- Asimakopoulou EM
- Asquith L
- Assahsah J
- Assamagan K
- Astalos R
- Astigarraga MEP
- Atkin RJ
- Atkinson M
- Atlay NB
- Atmani H
- Augsten K
- Avolio G
- Ayoub MK
- Azuelos G
- Bachacou H
- Bachas K
- Backes M
- Backman F
- Bagnaia P
- Bahmani M
- Bahrasemani H
- Bailey AJ
- Bailey VR
- Baines JT
- Bakalis C
- Baker OK
- Bakker PJ
- Balaji S
- Baldin EM
- Balek P
- Balli F
- Balunas WK
- Balz J
- Banas E
- Bandieramonte M
- Bandyopadhyay A
- Banerjee S
- Barak L
- Barbe WM
- Barberio EL
- Barberis D
- Barbero M
- Barbour G
- Barillari T
- Barisits M-S
- Barkeloo J
- Barklow T
- Barnea R
- Barnett BM
- Barnett RM
- Barnovska-Blenessy Z
- Baroncelli A
- Barone G
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- Barranco Navarro L
- Barreiro F
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- Barsov S
- Bartels F
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- Bartolini G
- Barton AE
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- Basalaev A
- Basan A
- Bassalat A
- Basso MJ
- Bates RL
- Batlamous S
- Batley JR
- Batool B
- Battaglia M
- Bauce M
- Bauer F
- Bauer KT
- Bawa HS
- Beacham JB
- Beau T
- Beauchemin PH
- Becherer F
- Bechtle P
- Beck HC
- Beck HP
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- Becot C
- Beddall A
- Beddall AJ
- Bednyakov VA
- Bedognetti M
- Bee CP
- Beermann TA
- Begalli M
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- Behera A
- Behr JK
- Beisiegel F
- Belfkir M
- Bell AS
- Bella G
- Bellagamba L
- Bellerive A
- Bellos P
- Beloborodov K
- Belotskiy K
- Belyaev NL
- Benchekroun D
- Benekos N
- Benhammou Y
- Benjamin DP
- Benoit M
- Bensinger JR
- Bentvelsen S
- Beresford L
- Beretta M
- Berge D
- Berger N
- Bergmann B
- Bergsten LJ
- Beringer J
- Berlendis S
- Berlingen JM
- Bernardi G
- Bernius C
- Bernlochner FU
- Berry T
- Berta P
- Bertella C
- Berthold A
- Bertram IA
- Besson N
- Bethani A
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- Betti A
- Bevan AJ
- Beyer J
- Bhattacharya DS
- Bhattarai P
- Bi R
- Bianchi RM
- Biebel O
- Biedermann D
- Bielski R
- Bierwagen K
- Biesuz N
- Biglietti M
- Billoud TR
- Bindi M
- Bingul A
- Bini C
- Biondi S
- Birman M
- Bisanz T
- Biswal JP
- Biswas D
- Bitadze A
- Bittrich C
- Bjorke K
- Blazek T
- Bloch I
- Blocker C
- Blue A
- Blumenschein U
- Bobbink GJ
- Bobrovnikov VS
- Bocchetta SS
- Bocci A
- Boeriu OEV
- Boerner D
- Bogavac D
- Bogdanchikov AG
- Bohm C
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- Bolz AE
- Bomben M
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- Bonilla JS
- Boonekamp M
- Booth CD
- Borecka-Bielska HM
- Borgna LS
- Borisov A
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- Bortfeldt J
- Bortoletto D
- Boscherini D
- Bosman M
- Bostanabad MG
- Bouaouda K
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- Bouhova-Thacker E
- Boumediene D
- Bourdarios CA
- Boutle SK
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- Buckley AG
- Budagov IA
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- Bugge MK
- Bulekov O
- Bullard BA
- Burch TJ
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- Burgard CD
- Burger AM
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- Burr JTP
- Burton CD
- Burzynski JC
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- Buzatu A
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- Calfayan P
- Callea G
- Caloba LP
- Caltabiano A
- Calvente Lopez S
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- Calvet TP
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- Camarero Munoz D
- Camarri P
- Camelia EA
- Camerlingo MT
- Cameron D
- Camincher C
- Campana S
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- Camplani A
- Campoverde A
- Canale V
- Canesse A
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- Capriles FGD
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- Cardarelli R
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- Carlson BT
- Carlson EM
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- Carney RMD
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- Carter JWS
- Carter TM
- Casado MP
- Casha AF
- Castillo Garcia L
- Castillo Gimenez V
- Castillo FL
- Castillo LRF
- Castro NF
- Catinaccio A
- Catmore JR
- Cattai A
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- Cavasinni V
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- Celli F
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- Cheremushkina E
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- Chevalerias TJA
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- Christopher LD
- Chu MC
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- Chudoba J
- Chwastowski JJ
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- Ciocio A
- Cirotto F
- Citron ZH
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- Clawson SE
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- Coimbra AEC
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- Cooper-Sarkar KAM
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- de Renstrom PAB
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- Etzion E
- Evans H
- Evans MO
- Ezhilov A
- Fabbri F
- Fabbri L
- Fabiani V
- Facini G
- Faisca Rodrigues Pereira RM
- Fakhrutdinov RM
- Falciano S
- Falke PJ
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- Fanti M
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- Farbin NA
- Farilla A
- Farina EM
- Farooque T
- Farrington SM
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- Fassouliotis D
- Fawcett WJ
- Fayard L
- Fedin OL
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- Feickert M
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- Fenton MJ
- Fenyuk AB
- Ferguson SW
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- Ferrante A
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- Ferrere D
- Ferretti C
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- Filthaut F
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- Fiolhais MCN
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- Fleck I
- Fleischmann P
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- Zu Theenhausen HM
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- Publication venue
- AMER PHYSICAL SOC
- Publication date
- 25/09/2020
- Field of study
This Letter describes a search for narrowly resonant new physics using a machine-learning anomaly
detection procedure that does not rely on signal simulations for developing the analysis selection. Weakly
supervised learning is used to train classifiers directly on data to enhance potential signals. The targeted
topology is dijet events and the features used for machine learning are the masses of the two jets. The
resulting analysis is essentially a three-dimensional search A → BC, for mA ∼ OðTeVÞ, mB; mC ∼
Oð100 GeVÞ and B, C are reconstructed as large-radius jets, without paying a penalty associated with
a large trials factor in the scan of the masses of the two jets. The full run 2 ffiffi
s p ¼ 13 TeV pp collision
dataset of 139 fb−1 recorded by the ATLAS detector at the Large Hadron Collider is used for the search.
There is no significant evidence of a localized excess in the dijet invariant mass spectrum between 1.8 and
8.2 TeV. Cross-section limits for narrow-width A, B, and C particles vary with mA, mB, and mC. For
example, when mA ¼ 3 TeV and mB ≳ 200 GeV, a production cross section between 1 and 5 fb is
excluded at 95% confidence level, depending on mC. For certain masses, these limits are up to 10 times
more sensitive than those obtained by the inclusive dijet search. These results are complementary to the
dedicated searches for the case that B and C are standard model boson
Combination of searches for heavy spin-1 resonances using 139 fb−1 of proton-proton collision data at s = 13 TeV with the ATLAS detector
- Author
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- Aakvaag E
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- Abicht NJ
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- Wamorkar T
- Wang AZ
- Wang C
- Wang C
- Wang H
- Wang J
- Wang R
- Wang R
- Wang R-J
- Wang S
- Wang SM
- Wang T
- Wang W
- Wang WT
- Wang X
- Wang X
- Wang X
- Wang Y
- Wang Y
- Wang Z
- Wang Z
- Wang Z
- Warburton A
- Ward RJ
- Warrack N
- Waterhouse S
- Watson AT
- Watson H
- Watson MF
- Watton E
- Watts G
- Waugh BM
- Webb JM
- Weber C
- Weber HA
- Weber MS
- Weber SM
- Wei C
- Wei Y
- Weidberg AR
- Weik EJ
- Weingarten J
- Weirich M
- Weiser C
- Wells CJ
- Wenaus T
- Wendland B
- Wengler T
- Wenke NS
- Wermes N
- Wessels M
- Wharton AM
- White A
- White AS
- White MJ
- Whiteson D
- Wickremasinghe L
- Wiedenmann W
- Wielers M
- Wiglesworth C
- Wilbern DJ
- Wilkens HG
- Wilkinson JJH
- Williams DM
- Williams HH
- Williams S
- Willocq S
- Wilson BJ
- Windischhofer PJ
- Winkel FI
- Winklmeier F
- Winter BT
- Winter JK
- Wittgen M
- Wobisch M
- Wolffs Z
- Wollrath J
- Wolter MW
- Wolters H
- Wong MC
- Woodward EL
- Worm SD
- Wosiek BK
- Wozniewski S
- Woźniak KW
- Wraight K
- Wu C
- Wu M
- Wu M
- Wu SL
- Wu X
- Wu Y
- Wu Z
- Wuerzinger J
- Wyatt TR
- Wynne BM
- Xella S
- Xia L
- Xia M
- Xiang J
- Xie M
- Xie X
- Xin S
- Xiong A
- Xiong J
- Xu D
- Xu H
- Xu L
- Xu R
- Xu T
- Xu Y
- Xu Z
- Xu Z
- Yabsley B
- Yacoob S
- Yamaguchi Y
- Yamashita E
- Yamauchi H
- Yamazaki T
- Yamazaki Y
- Yan J
- Yan S
- Yan Z
- Yang HJ
- Yang HT
- Yang S
- Yang T
- Yang X
- Yang X
- Yang Y
- Yang Y
- Yang Z
- Yao W-M
- Ye H
- Ye H
- Ye J
- Ye S
- Ye X
- Yeh Y
- Yeletskikh I
- Yeo BK
- Yexley MR
- Yin P
- Yorita K
- Younas S
- Young C
- Young CJS
- Yu C
- Yu Y
- Yuan M
- Yuan R
- Yue L
- Zaazoua M
- Zabinski B
- Zaid E
- Zak ZK
- Zakareishvili T
- Zakharchuk N
- Zambito S
- Zamora Saa JA
- Zang J
- Zanzi D
- Zaplatilek O
- Zeitnitz C
- Zeng H
- Zeng JC
- Zenger DT
- Zenin O
- Zenz S
- Zerradi S
- Zerwas D
- Zhai M
- Zhang DF
- Zhang J
- Zhang J
- Zhang K
- Zhang L
- Zhang L
- Zhang P
- Zhang R
- Zhang S
- Zhang S
- Zhang T
- Zhang X
- Zhang X
- Zhang Y
- Zhang Y
- Zhang Y
- Zhang Z
- Zhang Z
- Zhao H
- Zhao T
- Zhao Y
- Zhao Z
- Zhao Z
- Zhemchugov A
- Zheng J
- Zheng K
- Zheng X
- Zheng Z
- Zhong D
- Zhou B
- Zhou H
- Zhou N
- Zhou Y
- Zhou Y
- Zhu CG
- Zhu J
- Zhu Y
- Zhu Y
- Zhuang X
- Zhukov K
- Zimine NI
- Zinsser J
- Ziolkowski M
- Zoccoli A
- Zoch K
- Zorbas TG
- Zormpa O
- Zou W
- Zwalinski L
- Åkesson TPA
- Öncel ÖO
- Ženiš T
- Živković L
- Publication venue
- Springer Nature
- Publication date
- 19/04/2024
- Field of study
A combination of searches for new heavy spin-1 resonances decaying into different pairings of W, Z, or Higgs bosons, as well as directly into leptons or quarks, is presented. The data sample used corresponds to 139 fb−1 of proton-proton collisions at
= 13 TeV collected during 2015–2018 with the ATLAS detector at the CERN Large Hadron Collider. Analyses selecting quark pairs (qq, bb,
, and tb) or third-generation leptons (τν and ττ) are included in this kind of combination for the first time. A simplified model predicting a spin-1 heavy vector-boson triplet is used. Cross-section limits are set at the 95% confidence level and are compared with predictions for the benchmark model. These limits are also expressed in terms of constraints on couplings of the heavy vector-boson triplet to quarks, leptons, and the Higgs boson. The complementarity of the various analyses increases the sensitivity to new physics, and the resulting constraints are stronger than those from any individual analysis considered. The data exclude a heavy vector-boson triplet with mass below 5.8 TeV in a weakly coupled scenario, below 4.4 TeV in a strongly coupled scenario, and up to 1.5 TeV in the case of production via vector-boson fusion
Insight into response to mTOR inhibition when PKD1 and TSC2 are mutated
- Author
- A Untergasser
- AB Chapman
- AC Woerner
- AH Kirsch
- AJ Collins
- AL Serra
- BK Yoder
- C Cabrera-Lopez
- C Mancino
- CG Iglesias
- Cristina Cabrera-López
- D Boehm
- DM Davies
- DP Cina
- E Letavernier
- E Schonenberger
- Elisabet Ars
- F Diekmann
- G Distefano
- G Martignoni
- G Stallone
- G Walz
- Gemma Bullich
- H Northrup
- JJ Bissler
- JJ Bissler
- John J. Bissler
- Jose Ballarín
- JP Osborne
- JR Sampson
- JRW Yates
- KT Bae
- L Longa
- M Laplante
- MB Consugar
- O Sancak
- OZ Dalgaard
- P Kozlowski
- PB Crino
- Peter C. Harris
- PT Brook-Carter
- R Dere
- R Torra
- Roser Torra
- S Rossetti
- SL Dabora
- T Culty
- T Mochizuki
- T Weimbs
- Teresa Martí
- TR Hartman
- Violeta Català
- Y Oyazato
- YM Smulders
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Holography of the BTZ black hole, inside and out
- Author
- A Almheiri
- A Almheiri
- Anton de la Fuente
- AR Steif
- B Czech
- BS Kay
- CP Burgess
- CR Cramer
- CW Misner
- D Marolf
- DR Brill
- E Keski-Vakkuri
- E Witten
- EJ Martinec
- F Loran
- F Loran
- G Festuccia
- G Lifschytz
- G Sewell
- GL Sewell
- GT Horowitz
- I Heemskerk
- I Ichinose
- J Bisognano
- J Bisognano
- J Louko
- J McGreevy
- J Polchinski
- J Schwinger
- JB Hartle
- JM Maldacena
- JM Maldacena
- JM Maldacena
- JS Schwinger
- JS Schwinger
- K Papadodimas
- KT Mahanthappa
- L Fidkowski
- L Susskind
- L Susskind
- LV Keldysh
- M Bañados
- M Bañados
- M Berkooz
- O Aharony
- P Kraus
- PC Martin
- PM Bakshi
- PM Bakshi
- R Sundrum
- Raman Sundrum
- S Aminneborg
- S Carlip
- S Elitzur
- S Hemming
- S Holst
- S Weinberg
- SD Mathur
- SL Braunstein
- SS Gubser
- SW Hawking
- T Hartman
- T Inami
- UH Danielsson
- V Balasubramanian
- V Balasubramanian
- V Balasubramanian
- W Israel
- WG Unruh
- Y Takahasi
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Neurotropic virus infections as the cause of immediate and delayed neuropathology
- Author
- A Alker
- A Doja
- A Gagnon
- A Muehlenbachs
- A Pekosz
- A Rayamajhi
- A Srinivasan
- AD Haddow
- AH Reid
- AL Greninger
- AL Hartman
- AL Kistler
- Alan S. Brown
- Albert D. M. E. Osterhaus
- AM Powers
- AS Brown
- AS Brown
- B Hoffmann
- Bernd Hoffmann
- Byron E. E. Martina
- C Arpino
- C Herden
- C Korteweg
- C Tapparel
- CA Glaser
- Centers for Disease C Prevention
- Christiane Herden
- Corinna Trebst
- D Dionisio
- D Gilden
- D Nash
- D Nobach
- D Ruzek
- D van Riel
- Dasja Pajkrt
- Debby van Riel
- Dennis Tappe
- DH Libraty
- Diane E. Griffin
- DJ van Velden
- DP Agamanolis
- DR Hardie
- DR O’Leary
- DR Smith
- E Gelpi
- E Halliday
- F Baldelli
- F Cerna
- F Forest
- FC Chow
- G Borgherini
- G Palacios
- G van Marle
- Georges M. Verjans
- H Agut
- HA Rotbart
- Hannah E. Brindle
- HG Miller
- I Steiner
- IV Allen
- J Breuer
- J Sellner
- JA Johnstone
- JB Ghosh
- JE McJunkin
- Jeroen Kortekaas
- JF Drexler
- JI Morrow
- K Abul-Kasim
- K Aoki
- K Benschop
- K Dutta
- K Fujino
- K Ganesan
- K Mizuta
- K Morimoto
- K Schonberger
- Katja C. Wolthers
- KC Wolthers
- KL Mansfield
- KM Johnson
- KS Abdel-Wahab
- KS Honkavuori
- KT Wong
- KT Wong
- KT Wong
- KT Wong
- L Lindquist
- LA Selvey
- M Bourg
- M Hilbe
- M Horie
- M Hornig
- M Ludlow
- M Mohamed
- M Santini
- M Simon
- M Studahl
- M Wasay
- MA Nagel
- MA Nagel
- MA Samuel
- MA Silverman
- MA Verboon-Maciolek
- Martin Ludlow
- MCJ Cheeran
- MD de Jong
- MG Reyes
- MH Ooi
- MJ Griffiths
- MY Chowers
- N Taira
- O Eberhardt
- P Gerardin
- P Joki-Korpela
- P Wohlsein
- PD Garen
- PE Pellett
- Peter Wohlsein
- PM Southern Jr
- PM Winter
- PP van Thiel
- R Allen
- R Durrwald
- R Kaiser
- R Parboosing
- R Wurtz
- RE Mrak
- RE Rhoades
- RL Deresiewicz
- RL Doty
- RR Russell
- RS Klein
- RT Perry
- S de la Monte
- S Love
- S McQuaid
- S Shuangshoti
- SC Weaver
- SE Canetta
- SG Rodrigues
- SGF Wassilak
- SJ Bissel
- SJ Udow
- SK Mardekian
- SY Zhang
- T Armangue
- T Hemachudha
- T Iwamasa
- T Kuiken
- T Solomon
- T Solomon
- T Solomon
- T Solomon
- T Vandercam
- Tom Solomon
- TW Kelley
- U Meyding-Lamade
- VK Gowda
- VR Racaniello
- WG Winkler
- WJ Shieh
- WL Donohue
- Wolfgang Baumgärtner
- WR Chen
- Z Xiang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape
- Author
- Abecasis GR
- Ahluwalia TS
- Albrecht E
- Alves AC
- Bakker SJL
- Barlassina C
- Bartz TM
- Beilby J
- Bellis C
- Bergman RN
- Bergmann S
- Blangero J
- Bluher M
- Boehnke M
- Boerwinkle E
- Bonnycastle LL
- Boomsma DI
- Borecki IB
- Bornstein SR
- Bouchard C
- Bragg-Gresham JL
- Bruinenberg M
- Cadby G
- Campbell H
- Chambers JC
- Chasman DI
- Chen YDI
- Chiang CWK
- Chines PS
- Chu AY
- Collins FS
- Cucca F
- Cupples LA
- Cusi D
- D'Avila F
- de Geus EJC
- Dedoussis G
- Deloukas P
- Dimitriou M
- Doring A
- Eklund N
- Eriksson J
- Eriksson JG
- Esko T
- Farmaki AE
- Farrall M
- Feitosa MF
- Ferreira T
- Fischer K
- Forouhi NG
- Fox C
- Frayling T
- Friedrich N
- Gansevoort RT
- Gieger C
- Gjesing AP
- Glorioso N
- Goel A
- Gorski M
- Graff M
- Grallert H
- Grarup N
- Grassler J
- Grewal J
- Groop LC
- Hamsten A
- Hansen T
- Harder MN
- Hartman CA
- Hassinen M
- Hastie N
- Hattersley AT
- Havulinna AS
- Hayward C
- Heard-Costa NL
- Heid IM
- Heliovaara M
- Hicks AA
- Hillege H
- Hirschhorn JN
- Hofman A
- Holmen O
- Homuth G
- Hottenga JJ
- Hu F
- Huffman JE
- Hui JN
- Hunter DJ
- Husemoen LL
- Hveem K
- Hysi PG
- Isaacs A
- Ittermann T
- Jackson AU
- Jalilzadeh S
- James AL
- Jarvelin MR
- Jeff JM
- Jokinen E
- Jorgensen T
- Jousilahti P
- Jula A
- Justesen JM
- Justice AE
- Kahonen M
- Kajantie E
- Kanoni S
- Kaplan RC
- Karaleftheri M
- Keinanen-Kiukaanniemi SM
- Khaw KT
- Kinnunen L
- Knekt PB
- Koistinen HA
- Kolcic I
- Kooner IK
- Kooner JS
- Koskinen S
- Kovacs P
- Kristiansson K
- Kuh D
- Kutalik Z
- Kuusisto J
- Kyriakou T
- Laakso M
- Lahti J
- Laitinen T
- Lakka TA
- Langenberg C
- Leach IM
- Lehtimaki T
- Lewin AM
- Lichtner P
- Lindgren CM
- Lindstrom J
- Linneberg A
- Loos RJF
- Lorbeer R
- Lorentzon M
- Luan JA
- Luben R
- Lyssenko V
- Magi R
- Mahajan A
- Mangino M
- Mannisto S
- Manunta P
- McArdle WL
- McCarthy MI
- Mcknight B
- Medina-Gomez C
- Metspalu A
- Mihailov E
- Milani L
- Mills R
- Mohlke KL
- Monda KL
- Montasser ME
- Morris AP
- Muller G
- Muller-Nurasyid M
- Musk AW
- Narisu N
- Njolstad I
- Nolte IM
- North KE
- O'Connell JR
- Ohlsson C
- Oldehinkel AJ
- Ong KK
- Oostra BA
- Osmond C
- Palmer LJ
- Palotie A
- Pankow JS
- Paternoster L
- Pedersen O
- Penninx BW
- Perola M
- Perusse L
- Peters A
- Pichler I
- Pilia MG
- Polasek O
- Pramstaller PP
- Prokopenko I
- Psaty BM
- Puolijoki H
- Qi L
- Raitakari OT
- Rankinen T
- Rao DC
- Rauramaa R
- Rayner NW
- Ribel-Madsen R
- Rice TK
- Richards M
- Ridker PM
- Ried JS
- Rivadeneira F
- Rose LM
- Rudan I
- Ryan KA
- Salomaa V
- Salvi E
- Sanna S
- Sarzynski MA
- Schlessinger D
- Scholtens S
- Schwarz PEH
- Scott RA
- Sebert S
- Shudiner AR
- Smit JH
- Smith MT
- Snieder H
- Sorensen TIA
- Southam L
- Sparso TH
- Spector TD
- Stancakova A
- Stefansson K
- Steinthorsdottir V
- Stirrups K
- Stolk RP
- Strachan DP
- Strauch K
- Stringham HM
- Stumvoll M
- Sung YJ
- Swertz MA
- Swift AJ
- Tachmazidou I
- Teumer A
- Thorleifsson G
- Thorsteinsdottir U
- Tonjes A
- Tremblay A
- Tsafantakis E
- Tuomilehto J
- Uitterlinden AG
- Uusitupa M
- van der Harst P
- van der Most PJ
- van Dongen J
- van Duijn CM
- Van Vliet-Ostaptchouk JV
- Vandenput L
- Vartiainen E
- Venturini C
- Verweij N
- Viikari JS
- Vitart V
- Vohl MC
- Volker U
- Vollenweider P
- Vonk JM
- Waeber G
- Walker RW
- Wang SR
- Wareham NJ
- Watkins H
- Widen E
- Wild SH
- Willems SM
- Willemsen G
- Wilsgaard T
- Wilson JF
- Winkler TW
- Wong A
- Wright AF
- Yerges-Armstrong LM
- Zeggini E
- Zhang WH
- Zhao JH
- Zillikens MC
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 28/10/2022
- Field of study
Large consortia have revealed hundreds of genetic loci associated with anthropometric traits, one trait at a time. We examined whether genetic variants affect body shape as a composite phenotype that is represented by a combination of anthropometric traits. We developed an approach that calculates averaged PCs (AvPCs) representing body shape derived from six anthropometric traits (body mass index, height, weight, waist and hip circumference, waist-to-hip ratio). The first four AvPCs explain >99% of the variability, are heritable, and associate with cardiometabolic outcomes. We performed genome-wide association analyses for each body shape composite phenotype across 65 studies and meta-analysed summary statistics. We identify six novel loci: LEMD2 and CD47 for AvPC1, RPS6KA5/C14orf159 and GANAB for AvPC3, and ARL15 and ANP32 for AvPC4. Our findings highlight the value of using multiple traits to define complex phenotypes for discovery, which are not captured by single-trait analyses, and may shed light onto new pathways
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