7 research outputs found
Developmental stage-dependent metabolic regulation during meiotic differentiation in budding yeast
SPO24 Is a Transcriptionally Dynamic, Small ORF-Encoding Locus Required for Efficient Sporulation in Saccharomyces cerevisiae
Global alterations of the transcriptional landscape during yeast growth and development in the absence of Ume6-dependent chromatin modification
Fungal Pre-mRNA 3′-End Processing
3' end processing of messenger RNAs (mRNAs) is not only an essential step in eukaryotic gene expression, but it also impacts many other aspects of mRNA maturation and decay. A large portion of eukaryotic genes produce multiple mRNAs with different 3' ends through alternative cleavage/polyadenylation (APA). mRNA 3' processing and especially APA has been increasingly recognized as an important mechanism for gene regulation. Much of what we currently know about eukaryotic mRNA 3' processing came from studies using the genetically tractable yeast systems. Here we review the fungal mRNA 3' processing system by describing both the evolutionarily conserved mechanisms as well as the fungus-specific features
The Role of Alternative Sigma Factors in Pathogen Virulence
Alternative sigma factors enable bacteria to change the promoter specificity of the core RNA polymerase to enable the expression of genes that give them advantages in particular situations. The number of alternative sigma factors that bacteria produce varies greatly. Some bacteria, particularly those that reside in the soil have genes for multiple sigma factors. The soil living gram positive bacteria Sorangium cellulosum currently holds the record for the number of sigma factor genes at 109. Alternative sigma factors play important roles in the life cycle of many foodborne bacterial pathogens. In this review we will discuss: the structure and function of alternative sigma factors; the different families of alternative sigma factors; their regulation; the role of particular alternative sigma factors and the genes they control in the biology (particularly pathogenesis) of foodborne bacterial pathogens