A calculus of expandable stores: Continuation-and-environment-passing style translations

LICS 2020 will be held onlineInternational audienceThe call-by-need evaluation strategy for the λ-calculus is an evaluation strategy that lazily evaluates arguments only if needed, and if so, shares computations across all places where it is needed. To implement this evaluation strategy, abstract machines require some form of global environment. While abstract machines usually lead to a better understanding of the flow of control during the execution, facilitating in particular the definition of continuation-passing style translations , the case of machines with global environments turns out to be much more subtle. The main purpose of this paper is to understand how to type a continuation-and-environment-passing style translation , that is to say how to soundly translate in continuation-passing style a calculus with global environment. To this end, we introduce Fϒ , a generic calculus to define the target of such translations. In particular, Fϒ features a data type for typed stores and a mechanism of explicit coercions witnessing store extensions along environment-passing style translations. On the logical side, this broadly amounts to a Kripke forcing-like translation mixed with a negative translation (for the continuation-passing part). Since Fϒ allows for the definition of such translations for different source calculi (call-by-need, call-by-name, call-by-value) with different type systems (simple types, system F), we claim that it precisely captures the computational content of continuation-and-environment-passing style translations

Terminating Tableaux for Graded Hybrid Logic with Global Modalities and Role Hierarchies

We present a terminating tableau calculus for graded hybrid logic with global modalities, reflexivity, transitivity and role hierarchies. Termination of the system is achieved through pattern-based blocking. Previous approaches to related logics all rely on chain-based blocking. Besides being conceptually simple and suitable for efficient implementation, the pattern-based approach gives us a NExpTime complexity bound for the decision procedure

Noncomparabilities & Non Standard Logics

Many normative theories set forth in the welfare economics, distributive justice and cognate literatures posit noncomparabilities or incommensurabilities between magnitudes of various kinds. In some cases these gaps are predicated on metaphysical claims, in others upon epistemic claims, and in still others upon political-moral claims. I show that in all such cases they are best given formal expression in nonstandard logics that reject bivalence, excluded middle, or both. I do so by reference to an illustrative case study: a contradiction known to beset John Rawls\u27s selection and characterization of primary goods as the proper distribuendum in any distributively just society. The contradiction is avoided only by reformulating Rawls\u27s claims in a nonstandard form, which form happens also to cohere quite attractively with Rawls\u27s intuitive argumentation on behalf of his claims

High-Anxious Individuals Show Increased Chronic Stress Burden, Decreased Protective Immunity, and Increased Cancer Progression in a Mouse Model of Squamous Cell Carcinoma

In spite of widespread anecdotal and scientific evidence much remains to be understood about the long-suspected connection between psychological factors and susceptibility to cancer. The skin is the most common site of cancer, accounting for nearly half of all cancers in the US, with approximately 2–3 million cases of non-melanoma cancers occurring each year worldwide. We hypothesized that a high-anxious, stress-prone behavioral phenotype would result in a higher chronic stress burden, lower protective-immunity, and increased progression of the immuno-responsive skin cancer, squamous cell carcinoma. SKH1 mice were phenotyped as high- or low-anxious at baseline, and subsequently exposed to ultraviolet-B light (1 minimal erythemal dose (MED), 3 times/week, 10-weeks). The significant strengths of this cancer model are that it uses a normal, immunocompetent, outbred strain, without surgery/injection of exogenous tumor cells/cell lines, and produces lesions that resemble human tumors. Tumors were counted weekly (primary outcome), and tissues collected during early and late phases of tumor development. Chemokine/cytokine gene-expression was quantified by PCR, tumor-infiltrating helper (Th), cytolytic (CTL), and regulatory (Treg) T cells by immunohistochemistry, lymph node T and B cells by flow cytometry, adrenal and plasma corticosterone and tissue vascular-endothelial-growth-factor (VEGF) by ELISA. High-anxious mice showed a higher tumor burden during all phases of tumor development. They also showed: higher corticosterone levels (indicating greater chronic stress burden), increased CCL22 expression and Treg infiltration (increased tumor-recruited immuno-suppression), lower CTACK/CCL27, IL-12, and IFN-γ gene-expression and lower numbers of tumor infiltrating Th and CTLs (suppressed protective immunity), and higher VEGF concentrations (increased tumor angiogenesis/invasion/metastasis). These results suggest that the deleterious effects of high trait anxiety could be: exacerbated by life-stressors, accentuated by the stress of cancer diagnosis/treatment, and mediate increased tumor progression and/or metastasis. Therefore, it may be beneficial to investigate the use of chemotherapy-compatible anxiolytic treatments immediately following cancer diagnosis, and during cancer treatment/survivorship

In Support of a Patient-Driven Initiative and Petition to Lower the High Price of Cancer Drugs

Comment in Lowering the High Cost of Cancer Drugs--III. [Mayo Clin Proc. 2016] Lowering the High Cost of Cancer Drugs--I. [Mayo Clin Proc. 2016] Lowering the High Cost of Cancer Drugs--IV. [Mayo Clin Proc. 2016] In Reply--Lowering the High Cost of Cancer Drugs. [Mayo Clin Proc. 2016] US oncologists call for government regulation to curb drug price rises. [BMJ. 2015