32 research outputs found
Climate Information Services Training Manual for Training of Trainers: Promoting Adoption of Pigeonpea, Sorghum and Pearl Millet
This training manual has been developed to guide in providing training on strengthening capacities of agricultural extension officers, lead farmers, Small and Medium Enterprises (SMEs) and Farmer Producer Organizations (FPOs) to scale Climate Information Services (CIS) and Climate Smart Agriculture (CSA) innovations to achieve food and water security as well as building climate resilience
Climate Smart Agriculture Training Manual for Training of Trainers: Promoting Adoption of Pigeonpea, Sorghum and Pearl Millet
This training manual provides knowledge and skills to government extension officers and lead farmers on the concept of climate smart agriculture to empower them to train farmers on appropriate technologies, innovations and management practices against climate change risk
Integrated ag-data hub in Zambia using existing CIS platforms coupled with the iSAT and DEA data cube
This report is divided into two parts (i) technical progress on building a prototype of the Agdatahub as well as generation and dissemination of advisories using iSAT (ii) governance mechanisms and stakeholder engagement to host Agdatahub
Evidence and perceptions of rainfall change in Malawi: Do maize cultivar choices enhance climate change adaptation in sub-Saharan Africa?
Getting farmers to adopt new cultivars with greater tolerance for coping with climatic extremes and variability is considered as one way of adapting agricultural production to climate change. However, for successful adaptation to occur, an accurate recognition and understanding of the climate signal by key stakeholders (farmers, seed suppliers and agricultural extension services) is an essential precursor. This paper presents evidence based on fieldwork with smallholder maize producers and national seed network stakeholders in Malawi from 2010 to 2011, assessing understandings of rainfall changes and decision-making about maize cultivar choices. Our findings show that preferences for short-season maize cultivars are increasing based on perceptions that season lengths are growing shorter due to climate change and the assumption that growing shorter-season crops represents a good strategy for adapting to drought. However, meteorological records for the two study areas present no evidence for shortening seasons (or any significant change to rainfall characteristics), suggesting that short-season cultivars may not be the most suitable adaptation option for these areas. This demonstrates the dangers of oversimplified climate information in guiding changes in farmer decision-making about cultivar choice
Unfolded protein response in cancer: the Physician's perspective
The unfolded protein response (UPR) is a cascade of intracellular stress signaling events in response to an accumulation of unfolded or misfolded proteins in the lumen of the endoplasmic reticulum (ER). Cancer cells are often exposed to hypoxia, nutrient starvation, oxidative stress and other metabolic dysregulation that cause ER stress and activation of the UPR. Depending on the duration and degree of ER stress, the UPR can provide either survival signals by activating adaptive and antiapoptotic pathways, or death signals by inducing cell death programs. Sustained induction or repression of UPR pharmacologically may thus have beneficial and therapeutic effects against cancer. In this review, we discuss the basic mechanisms of UPR and highlight the importance of UPR in cancer biology. We also update the UPR-targeted cancer therapeutics currently in clinical trials
Recommended from our members
The implications of rural perceptions of water scarcity on differential adaptation behaviour in Rajasthan, India
Water scarcity is one of the most critical issues facing agriculture today. To understand how people manage the risk of water scarcity and growing pressures of increased climate variability, exploring perceptions of risk and how these perceptions feed into response behaviour and willingness to adapt is critical. This paper revisits existing frameworks that conceptualise perceptions of environmental risk and decision-making, and uses empirical evidence from an in-depth study conducted in Rajasthan, India, to emphasise how individual and collective memories, and experience of past extreme
events shape current definitions and future expectations of climatic risks. In doing so, we demonstrate the value of recognising the role of local perceptions of water scarcity (and how they vary between and within households) in constructing social vulnerability.
We also discuss the implications of these perceptions of risk when understanding and incentivising local adaptation pathways
Climate Risk Management in Smallholder Farming Systems in the Semiarid Tropics
Climate risk management in the semi-arid tropics (SAT) is one of the major challenges to achieving food security and development in India and large parts of sub-Saharan Africa and also in the case of Australia. Climate-induced production risk associated with the current season-to-season variability of rainfall is a major barrier in making rainfed agriculture sustainable and viable farm business. Since season outcomes are uncertain, even with the best climate information, farmers have limited flexibility in applying management with confidence. In fact in risky environments, farmers most often respond by adapting a risk averse strategy and are reluctant to invest in even risk reducing measures (Leathers and Quiggin 1991). In the SAT agro-ecologies, there are a limited range of enterprise or crop options to consider which may be further restricted by cultural traditions, food preferences or market opportunities.While there are fundamental differences between large scale commercial farms in Australia compared to the predominantly smallholder resource poor farms found in India, when it comes to climate risk management in the SAT, there are many commonalities. The purpose of this paper is therefore to (i) establish a framework for managing climate variability and transforming farming systems to be more resilient and sustainable for future climates; and (ii) provide some case study examples from climate risk management in low rainfall cropping system in Australia and consider how they may be applied in smallholder systems of the SAT