156 research outputs found
Molecular evidence for increased regulatory conservation during metamorphosis, and against deleterious cascading effects of hybrid breakdown in Drosophila
- Author
- Publication venue
- BioMed Central
- Publication date
- 01/01/1992
- Field of study
<p>Abstract</p> <p>Background</p> <p>Speculation regarding the importance of changes in gene regulation in determining major phylogenetic patterns continues to accrue, despite a lack of broad-scale comparative studies examining how patterns of gene expression vary during development. Comparative transcriptional profiling of adult interspecific hybrids and their parental species has uncovered widespread divergence of the mechanisms controlling gene regulation, revealing incompatibilities that are masked in comparisons between the pure species. However, this has prompted the suggestion that misexpression in adult hybrids results from the downstream cascading effects of a subset of genes improperly regulated in early development.</p> <p>Results</p> <p>We sought to determine how gene expression diverges over development, as well as test the cascade hypothesis, by profiling expression in males of <it>Drosophila melanogaster</it>, <it>D. sechellia</it>, and <it>D. simulans</it>, as well as the <it>D. simulans </it>(♀) × <it>D. sechellia </it>(♂) male F1 hybrids, at four different developmental time points (3rd instar larval, early pupal, late pupal, and newly-emerged adult). Contrary to the cascade model of misexpression, we find that there is considerable stage-specific autonomy of regulatory breakdown in hybrids, with the larval and adult stages showing significantly more hybrid misexpression as compared to the pupal stage. However, comparisons between pure species indicate that genes expressed during earlier stages of development tend to be more conserved in terms of their level of expression than those expressed during later stages, suggesting that while Von Baer's famous law applies at both the level of nucleotide sequence and expression, it may not apply necessarily to the underlying overall regulatory network, which appears to diverge over the course of ontogeny and which can only be ascertained by combining divergent genomes in species hybrids.</p> <p>Conclusion</p> <p>Our results suggest that complex integration of regulatory circuits during morphogenesis may lead to it being more refractory to divergence of underlying gene regulatory mechanisms - more than that suggested by the conservation of gene expression levels between species during earlier stages. This provides support for a 'developmental hourglass' model of divergence of gene expression in <it>Drosophila </it>resulting in a highly conserved pupal stage.</p
Biodiversity modelling in practice - predicting bird and woody plant species richness on farmlands
- Author
- [LBGR] Landesamt für Bergbau Geologie und Rohstoffe Brandenburg
- [LDBV] Landesamt für Digitalisierung Breitband und Vermessung
- [LLUR] Landesamt für Landwirtschaft Umwelt und ländliche Räume
- Boots AJ
- Buttler KP
- Chamberlain DE
- Christensen KD
- Faraway J. J
- Hastie T
- Heusinger G
- Hinsley SA
- Huwer A
- Kempa D
- Kramer M
- Kretschmer H
- Ludwig G
- Orlowski G
- O’Connor RJ
- Schröder H
- Secretariat of the Convention on Biological Diversity
- Svensson L
- Südbeck P
- Südbeck P
- Voigtländer U
- von Haaren C
- von Haaren C
- von Haaren C
- Zwölfer H
- Publication venue
- Milton Park : Taylor & Francis
- Publication date
- 01/01/2019
- Field of study
In light of decreasing species richness on farmland and an increasing awareness of biodiversity issues among customers and food companies, concepts and models to evaluate and enhance farmland biodiversity are greatly needed. It is important that the models are easy to apply as they have to be utilized by practitioners such as farmers and their consultants. In this study, simple but valid predictors were identified to rapidly assess the species richness of birds and woody plants in hedgerows, an important farmland landscape element. Hedgerows were sampled in seven agricultural landscapes throughout Germany. By means of automatic model selection procedures, linear regression models were estimated to predict bird and woody plant species richness. Cross validation procedures were carried out in order to visualize model selection uncertainty and estimate the prediction error. Due to a rather high prediction error, the model for plants can only be recommended for use when field work is not feasible. The model for birds, however, explained 70.8% of the variance in species numbers. It may help farmers, food companies and nature conservation agencies to rapidly evaluate bird species richness in hedgerows on farmland and to identify potentials and appropriate measures for enhancing it
On the phylogeny of Mustelidae subfamilies: analysis of seventeen nuclear non-coding loci and mitochondrial complete genomes
- Author
- A Rambaut
- A Rokas
- A Stamatakis
- AF Smit
- AJ Drummond
- B Larget
- C Ané
- C Schröder
- C-I Wu
- CA Matthee
- CAM Russo
- CM Durando
- D Posada
- D Posada
- Dan Peng
- DL Swofford
- DW Coltman
- E Benavides
- E Eizirik
- F Ronquist
- F Schlunegger
- FF Steininger
- GF Baryshnikov
- GF Baryshnikov
- H Akaike
- H Nishihara
- H Shimodaira
- H Shimodaira
- H Shimodaira
- Hang Lee
- HH van der Vlugt
- HN Bryant
- HP Luterbacher
- J Castresana
- J Felsenstein
- J Glazek
- J Glazek
- J Jurka
- J Marmi
- J Pecon-Slattery
- JD Thompson
- Jiang Liu
- JJ Sato
- JJ Sato
- JJ Sato
- JJ Sato
- JW Dragoo
- K Kawai
- K Tamura
- KP Koepfli
- KP Koepfli
- KP Koepfli
- L Yu
- L Yu
- L Yu
- L Yu
- L Yu
- L Yu
- L Yu
- L Yu
- Li Yu
- Lu Liang
- M Beltrán
- M Das
- M Fortelius
- M Miya
- M Morlo
- M Möller-Krull
- M Möller-Krull
- M Nei
- M Nikaido
- M Nikaido
- M Wolsan
- M Wolsan
- M Wolsan
- M Wolsana
- MF Minnick
- ML Dalebout
- Muyeong Lee
- N Giannasi
- NS Vassetzky
- Oliver A Ryder
- ORP Bininda-Emonds
- P Pamilo
- Pengtao Luan
- R Zardoya
- RH Waterston
- RK Wayne
- RL Cunha
- RL Mueller
- RM Nowak
- S Creer
- S Creer
- S Joly
- S Joly
- SG Goto
- SM Zehr
- T Hosoda
- T Sasaki
- T Yonezawa
- TL Fulton
- V Friesen
- VL Friesen
- W Nie
- WS Moore
- Yaping Zhang
- Publication venue
- BioMed Central
- Publication date
- 01/01/2011
- Field of study
<p>Abstract</p> <p>Background</p> <p>Mustelidae, as the largest and most-diverse family of order Carnivora, comprises eight subfamilies. Phylogenetic relationships among these Mustelidae subfamilies remain argumentative subjects in recent years. One of the main reasons is that the mustelids represent a typical example of rapid evolutionary radiation and recent speciation event. Prior investigation has been concentrated on the application of different mitochondrial (mt) sequence and nuclear protein-coding data, herein we employ 17 nuclear non-coding loci (>15 kb), in conjunction with mt complete genome data (>16 kb), to clarify these enigmatic problems.</p> <p>Results</p> <p>The combined nuclear intron and mt genome analyses both robustly support that Taxidiinae diverged first, followed by Melinae. Lutrinae and Mustelinae are grouped together in all analyses with strong supports. The position of Helictidinae, however, is enigmatic because the mt genome analysis places it to the clade uniting Lutrinae and Mustelinae, whereas the nuclear intron analysis favores a novel view supporting a closer relationship of Helictidinae to Martinae. This finding emphasizes a need to add more data and include more taxa to resolve this problem. In addition, the molecular dating provides insights into the time scale of the origin and diversification of the Mustelidae subfamilies. Finally, the phylogenetic performances and limits of nuclear introns and mt genes are discussed in the context of Mustelidae phylogeny.</p> <p>Conclusion</p> <p>Our study not only brings new perspectives on the previously obscured phylogenetic relationships among Mustelidae subfamilies, but also provides another example demonstrating the effectiveness of nuclear non-coding loci for reconstructing evolutionary histories in a group that has undergone rapid bursts of speciation.</p
Toward a model-based predictive controller design in brain-computer interfaces
- Author
- A Bashashati
- A Schlögl
- A Schlögl
- AB Schwartz
- B Blankertz
- B Blankertz
- B Flury
- BC Kuo
- CJC Burges
- D Garrett
- DJ Krusienski
- DJ McFarland
- DJ McFarland
- DJ McFarland
- DJ McFarland
- DJ McFarland
- DW Clarke
- EF Camacho
- F Lotte
- G Blanchard
- G Muller-Putz
- G Pfurtscheller
- G Pfurtscheller
- G Santhanam
- G Schalk
- G Schalk
- GE Fabiani
- GEP Box
- H Akaike
- J Carmena
- J Millan
- JR Wolpaw
- JR Wolpaw
- KP Burnham
- L Yu
- LR Hochberg
- M Ding
- M Fatourechi
- M Fatourechi
- M Kamrunnahar
- M Kaper
- M Pregenzer
- M Schröder
- M. Kamrunnahar
- MD Serruya
- MJ Zhong
- N Birbaumer
- N. S. Dias
- NS Dias
- O Bai
- PL Nunez
- PL Nunez
- PR Kennedy
- R Srinivasan
- R Srinivasan
- RA Johnson
- S. J. Schiff
- SJ Schiff
- X Liao
- ZA Keirn
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/05/2011
- Field of study
A first step in designing a robust and optimal model-based predictive controller (MPC) for brain-computer interface (BCI) applications is presented in this article. An MPC has the potential to achieve improved BCI performance compared to the performance achieved by current ad hoc, nonmodel-based filter applications. The parameters in designing the controller were extracted as model-based features from motor imagery task-related human scalp electroencephalography. Although the parameters can be generated from any model-linear or non-linear, we here adopted a simple autoregressive model that has well-established applications in BCI task discriminations. It was shown that the parameters generated for the controller design can as well be used for motor imagery task discriminations with performance (with 8-23% task discrimination errors) comparable to the discrimination performance of the commonly used features such as frequency specific band powers and the AR model parameters directly used. An optimal MPC has significant implications for high performance BCI applications.Grants K25NS061001
(MK) and K02MH01493 (SJS) from the National
Institute of Neurological Disorders And Stroke
(NINDS) and the National Institute of Mental Health
(NIMH), the Portuguese Foundation for Science and
Technology (FCT) Grant SFRH/BD/21529/2005
(NSD), the Pennsylvania Department of Community
and Economic Development Keystone Innovation
Zone Program Fund (SJS), and the Pennsylvania
Department of Health using Tobacco Settlement Fund
(SJS)
Accelerated discovery of two crystal structure types in a complex inorganic phase field
- Author
- A Demont
- A Nakatsuka
- AI Bilyi
- AJ Morris
- AK Cheetham
- AO Lyakhov
- B Szymanik
- BG Dick
- BWH van Beest
- C. Collins
- DJ Wales
- E Antic-Fidancev
- E Chtoun
- E Ruiz-Trejo
- E Tillmanns
- E Tillmanns
- E Tillmanns
- EF Bertaut
- F Maglia
- G Barr
- G Hautier
- G Kresse
- G Kresse
- G. F. S. Whitehead
- G. R. Darling
- GD Fallon
- GM Sheldrick
- GM Sheldrick
- H Kobayashi
- HJ Deiseroth
- HJ Deiseroth
- HL Chen
- J McKittrick
- J. B. Claridge
- JC de Mello
- JC Schön
- JD Gale
- JMS Skakle
- JP Perdew
- KK Wu
- KP Schröder
- LG Liu
- M Faucher
- M Feng
- M Jansen
- M O’Keeffe
- M. J. Pitcher
- M. J. Rosseinsky
- M. S. Dyer
- M. Zanella
- MA Ghebouli
- MS Dyer
- OV Dolomanov
- P. Mandal
- Q Huang
- Q Zhu
- R Gautier
- RC Baetzold
- RH Buttner
- S Geller
- S Geller
- SM Woodley
- SM Woodley
- SP Ong
- T Ishihara
- T Siegrist
- TA Vanderah
- TFT Cerqueira
- TL Barry
- TM Sabine
- TS Bush
- V Kahlenberg
- V Kahlenberg
- V Kahlenberg
- V Kahlenberg
- V Kahlenberg
- V Petricek
- W Hofmeister
- WG Mumme
- X Kuang
- X Kuang
- YC Wang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 08/06/2017
- Field of study
The discovery of new materials is hampered by the lack of efficient approaches to the exploration of both the large number of possible elemental compositions for such materials, and of the candidate structures at each composition1. For example, the discovery of inorganic extended solid structures has relied on knowledge of crystal chemistry coupled with time-consuming materials synthesis with systematically varied elemental ratios2,3. Computational methods have been developed to guide synthesis by predicting structures at specific compositions4,5,6 and predicting compositions for known crystal structures7,8, with notable successes9,10. However, the challenge of finding qualitatively new, experimentally realizable compounds, with crystal structures where the unit cell and the atom positions within it differ from known structures, remains for compositionally complex systems. Many valuable properties arise from substitution into known crystal structures, but materials discovery using this approach alone risks both missing best-in-class performance and attempting design with incomplete knowledge8,11. Here we report the experimental discovery of two structure types by computational identification of the region of a complex inorganic phase field that contains them. This is achieved by computing probe structures that capture the chemical and structural diversity of the system and whose energies can be ranked against combinations of currently known materials. Subsequent experimental exploration of the lowest-energy regions of the computed phase diagram affords two materials with previously unreported crystal structures featuring unusual structural motifs. This approach will accelerate the systematic discovery of new materials in complex compositional spaces by efficiently guiding synthesis and enhancing the predictive power of the computational tools through expansion of the knowledge base underpinning them
Nutrition in children with CRF and on dialysis
- Author
- A Canepa
- A Canepa
- A Canepa
- A Canepa
- A Canepa
- A Canepa
- A Canepa
- A Claris-Appiani
- A Claris-Appiani
- A Edefonti
- A Edefonti
- A Edefonti
- A Edefonti
- A Merouani
- A Omolja
- A Quan
- A Tom
- AM Neu
- AM Pereira
- AM Wingen
- AS Brem
- AS Brem
- AS Brem
- B Tonshoff
- BA Fivush
- BA Warady
- BD Kuizon
- BJ Foster
- BJ Foster
- BW Davies
- C Kleinknecht
- C Polito
- C Schröder
- C Stefanidis
- CD Hanevold
- CF Strife
- CJ Stefanidis
- CL Abitbol
- CL Abitbol
- CL Abitbol
- CP Schmitt
- CS Wong
- CS Wong
- E McSherry
- E Verrina
- ED Brewer
- EE Reed
- EN Ellis
- F Bellisle
- F Cano
- F Schaefer
- F Schaefer
- G Orejas
- G Rizzoni
- GM Shah
- I Krause
- I Salusky
- IB Salusky
- IJ Ramage
- IJ Ramage
- IM Ratsch
- IU Qamar
- IU Qamar
- IU Qamar
- J Karlberg
- J Zachwieja
- JA Kari
- JD Louden
- JE Coleman
- JE Coleman
- JE Coleman
- JE Lewy
- JP Brady
- JW Foreman
- K Jabs
- K Kalantar-Zadeh
- K Scharer
- K Scharer
- KF Jureidini
- KJ van Hoeck
- KP Morris
- L Dello Strogolo
- L Rees
- LA Baur
- LA Slomowitz
- LC de Graaff
- Lesley Rees
- LJ Norman
- LJ Norman
- LJ Norman
- LJ Norman
- M Daschner
- M Guillot
- M Honda
- M Kilic
- M Kriley
- M Van Dyck
- M Van Dyck
- MA Azocar
- MG Seikaly
- N Besbas
- N Besbas
- N Qayyum
- National Kidney Foundation
- O Marsenic
- P Orellana
- R Murakami
- R Shroff
- R Shroff
- R Van Diemen-Steenvoorde
- RH Mak
- RH Mak
- RM Hanning
- RM Hanning
- RS Parekh
- RW Jones
- S Mir
- SC Waller
- SE Ledermann
- SE Ledermann
- SE Ledermann
- SL Furth
- SL Furth
- SL Goldstein
- T Holtta
- T Karupaiah
- T Tamura
- T Wapensky
- V Chadha
- V Shaw
- Vanessa Shaw
- Warady
- Y Boirie
- Z Zadik
- Publication venue
- Springer-Verlag
- Publication date
- 01/01/2007
- Field of study
The objectives of this study are: (1) to understand the importance of nutrition in normal growth; (2) to review the methods of assessing nutritional status; (3) to review the dietary requirements of normal children throughout childhood, including protein, energy, vitamins and minerals; (4) to review recommendations for the nutritional requirements of children with chronic renal failure (CRF) and on dialysis; (5) to review reports of spontaneous nutritional intake in children with CRF and on dialysis; (6) to review the epidemiology of nutritional disturbances in renal disease, including height, weight and body composition; (7) to review the pathological mechanisms underlying poor appetite, abnormal metabolic rate and endocrine disturbances in renal disease; (8) to review the evidence for the benefit of dietetic input, dietary supplementation, nasogastric and gastrostomy feeds and intradialytic nutrition; (9) to review the effect of dialysis adequacy on nutrition; (10) to review the effect of nutrition on outcome
Search for Higgs Boson Pair Production in the Four b Quark Final State in Proton-Proton Collisions at root s=13 TeV
- Author
- Aarrestad T
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullah WW
- Abdullin S
- Abercrombie D
- Abreu A
- Acharya H
- Acosta D
- Adam W
- Adamidis K
- Adams E
- Adams M
- Adams T
- Addesa F
- Adloff C
- Adzic P
- Adán DP
- Afanasiev S
- Agapitos A
- Agarwal G
- Aggleton R
- Agram J
- Aguilar-Benitez M
- Ahmad A
- Ahmad M
- Ahmad WH
- Ahmed A
- Ahuja S
- Aime` C
- Akchurin N
- Akgun B
- Akpinar A
- Albergo S
- Albert A
- Albrecht S
- Albrow M
- Aleksandrov A
- Alexander J
- Alhusseini M
- Alimena J
- Alison J
- Almond J
- Alonso AG
- Alpana K
- Alvarez JR
- Alverson G
- Alves G
- Aly R
- Alyari M
- Amapane N
- Amaral SSD
- Amarilo KM
- Ambrozas M
- Amendola C
- Amin N
- Amram O
- Amsler C
- An S
- An Y
- Anagnostou G
- Anampa KH
- Andrea J
- Andreassi G
- Andreev V
- Andreev Y
- Andrejkovic J
- Andrews M
- Androsov K
- Angioni GP
- Anguiano J
- Antchev G
- Antequera JB
- Anthony D
- Antunovic Z
- Anuar AB
- Apollinari G
- Apparu D
- Appelt E
- Apresyan A
- Apyan A
- Araujo M
- Arcaro D
- Arcidiacono R
- Arenton M
- Argiro S
- Arneodo M
- Aruta C
- Asavapibhop B
- Asawatangtrakuldee C
- Asenov P
- Asghar M
- Asilar E
- Askew A
- Asmuss P
- Atakisi I
- Attikis A
- Auffray E
- Aushev T
- Auzinger G
- Avati V
- Avery P
- Avila C
- Awais A
- Awan M
- Ayala E
- Ayala G
- Azarkin M
- Azhgirey I
- Aziz T
- Azzi P
- Azzurri P
- Baarmand M
- Babaev A
- Bacchetta N
- Bachiller I
- Bachtis M
- Backhaus M
- Baden A
- Baechler J
- Bagliesi G
- Bahinipati S
- Baillon P
- Bainbridge R
- Bakas G
- Bakhshiansohi H
- Bakshi A
- Ban Y
- Band R
- Bandyopadhyay H
- Banerjee S
- Banos LE
- Bansal S
- Barbagli G
- Barberis E
- Bargassa P
- Baringer P
- Barnes V
- Barney D
- Baron O
- Barrera CB
- Barrera CO
- Barria P
- Bartek R
- Bartosik N
- Bartók M
- Bastos D
- Battilana C
- Baty A
- Bauer G
- Bauerdick L
- Baxter S
- Bayatmakou M
- Bayshev I
- Bean A
- Beauceron S
- Beaudette F
- Becerra DS
- Bechtel J
- Bedoya CF
- Beghin D
- Behera P
- Behera S
- Behnke O
- Bein S
- Belforte S
- Bell K
- Bellan R
- Belloni A
- Bellora A
- Belyaev A
- Benaglia A
- Benato L
- Bencze G
- Bendavid J
- Benecke A
- Benelli G
- Benitez J
- Benussi L
- Bergauer T
- Berger P
- Beri S
- Bernardes C
- Bernet C
- Berry D
- Berryhill J
- Bertacchi V
- Besancon M
- Bestintzanos I
- Bethani A
- Beyrouthy T
- Bhal E
- Bhardwaj A
- Bharthuar S
- Bharti M
- Bhat P
- Bhatnagar V
- Bhattacharya R
- Bhattacharya S
- Bhowmik D
- Bhowmik S
- Bhyun J
- Bi R
- Bialkowska H
- Bianchini L
- Bianco M
- Bianco S
- Biino C
- Bilei G
- Bilin B
- Bindhu VMN
- Bisello D
- Black K
- Blekman F
- Blinov V
- Bloch D
- Bloch P
- Bloom K
- Bluj M
- Blumenfeld B
- Boccali T
- Bocci A
- Bodek A
- Boimska B
- Boldrini G
- Boletti A
- Bologna S
- Bols E
- Bonacorsi D
- Bonanomi M
- Bonham B
- Bonilla J
- Bonomally S
- Boos E
- Boran F
- Borg J
- Borgonovi L
- Bornheim A
- Borras K
- Borshch V
- Bortignon P
- Bose T
- Bossini E
- Botta C
- Botta V
- Boudoul G
- Bouhali O
- Bourgatte G
- Bourilkov D
- Bouza VR
- Bozzo M
- Bragagnolo A
- Braghieri A
- Brainerd C
- Branson J
- Breedon R
- Breeze S
- Brew C
- Bright-Thonney S
- Brigliadori L
- Brigljevic V
- Brinkerhoff A
- Brivio F
- Brom J
- Brommer S
- Brooke J
- Brown R
- Brunner D
- Bruno G
- Bryant P
- Bryson M
- Brzhechko D
- Brücken E
- Bucci R
- Buccilli A
- Buchmuller O
- Budkouski D
- Bueghly J
- Bundock A
- Bunichev V
- Bunkowski K
- Buontempo S
- Burkart M
- Burkett K
- Burkle B
- Burt K
- Bury F
- Busson P
- Busza W
- Butalla S
- Butler J
- Butler P
- Butz E
- Bychkova O
- Bylinkin A
- Bylsma B
- Bärtschi P
- Caballero IG
- Cabrera A
- Cabrillo I
- Cadamuro L
- Caillol C
- Cakir A
- Calandri A
- Calderon A
- Cali I
- Calligaris L
- Calzaferri S
- Camen C
- Caminada L
- Campagnari C
- Campana M
- Campanini R
- Campbell A
- Campderros JD
- Camporesi T
- Candelise V
- Canelli M
- Canepa A
- Cankocak K
- Capiluppi P
- Cappati A
- Caputo C
- Caraway B
- Cardini A
- Cardwell B
- Carle A
- Carlin R
- Carnahan T
- Carnevali F
- Cartiglia N
- Carvalho W
- Casarsa M
- Caspart R
- Cassese A
- Castaldi R
- Castilla-Valdez H
- Castro A
- Cavallari F
- Cavallo F
- Cavallo N
- Cavanaugh R
- Ceard L
- Ceballos GG
- Ceccarelli R
- Cepaitis V
- Cepeda M
- Cerati G
- Cerci DS
- Cerci S
- Cerminara G
- Cerrada M
- Cerri O
- Cetorelli F
- Chabert E
- Chahal G
- Chang P
- Chanon N
- Chao Y
- Chapon E
- Charlot C
- Chatterjee R
- Chatterjee S
- Chaudhary G
- Chauhan S
- Chawla R
- Checchia P
- Chekhovsky V
- Chen C
- Chen G
- Chen H
- Chen K
- Chen M
- Chen P
- Chen X
- Chen Y
- Chen Z
- Chenarani S
- Cheng C
- Cheng T
- Cheng Y
- Cherepanov V
- Chernyavskaya N
- Chertok M
- Cheung H
- Chhibra S
- Chiarito B
- Chinellato J
- Chistov R
- Chlebana F
- Cho S
- Choi J
- Choi M
- Choi S
- Chou J
- Choudhary B
- Choudhury S
- Chowdhury SR
- Christoforou K
- Chudasama R
- Chwalek T
- Ciangottini D
- Cifuentes JB
- Ciocci M
- Cipriani M
- Citron M
- Cittolin S
- Ciulli V
- Civinini C
- Claes D
- Clare R
- Clement E
- Clerbaux B
- Cockerill D
- Coello ML
- Colaleo A
- Coldham K
- Cole J
- Colino N
- Collard C
- Colling D
- Colombina F
- Cometti S
- Connor P
- Contardo D
- Conway J
- Cooke C
- Cooper S
- Cooperstein S
- Corcodilos L
- Cormier K
- Cornelis T
- Cortezon EP
- Cosby C
- Cossutti F
- Costa M
- Costa S
- Coubez X
- Couderc F
- Cousins R
- Covarelli R
- Cox B
- Cox P
- Cranshaw D
- Creanza D
- Cremonesi M
- Cristella L
- Cruz SS
- Csanad M
- Csorgo T
- Cuevas J
- Cuevas PM
- Cuffiani M
- Cumalat J
- Cummings G
- Cussans D
- Cutts D
- Czellar S
- Da Costa E
- Da Rold A
- Da Silveira G
- Dabrowski A
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- Álvarez CR
- Özçelik Ö
- Publication venue
- Publication date
- 01/01/2022
- Field of study
Search for invisible decays of the Higgs boson produced via vector boson fusion in proton-proton collisions at root s=13 TeV
- Author
- Aarrestad T
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdelalim A
- Abdullin S
- Abercrombie D
- Abreu A
- Acharya H
- Acosta D
- Acosta HE
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- Aggleton R
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- Ahmad A
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- Zygala L
- Álvarez CR
- Özçelik Ö
- Publication venue
- Publication date
- 01/01/2022
- Field of study
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
- Author
- Abdel-Aziz AK
- Abdelfatah S
- Abdellatif M
- Abdoli A
- Abel S
- Abeliovich H
- Abildgaard MH
- Abudu YP
- Acevedo-Arozena A
- Adamopoulos IE
- Adeli K
- Adolph TE
- Adornetto A
- Aflaki E
- Agam G
- Agarwal A
- Aggarwal BB
- Agnello M
- Agostinis P
- Agrewala JN
- Agrotis A
- Aguilar PV
- Ahmad ST
- Ahmed ZM
- Ahumada-Castro U
- Aits S
- Aizawa S
- Akkoc Y
- Akoumianaki T
- Akpinar HA
- Al-Abd AM
- Al-Akra L
- Al-Gharaibeh A
- Alaoui-Jamali MA
- Alberti S
- Alcocer-Gómez E
- Alessandri C
- Ali M
- Alim Al-Bari MA
- Aliwaini S
- Alizadeh J
- Almacellas E
- Almasan A
- Alonso A
- Alonso GD
- Altan-Bonnet N
- Altieri DC
- Alves da Costa C
- Alves S
- Alzaharna MM
- Amadio M
- Amantini C
- Amaral C
- Ambrosio S
- Amer AO
- Ammanathan V
- An Z
- Andersen SU
- Andrabi SA
- Andrade-Silva M
- Andres AM
- Angelini S
- Ann D
- Anozie UC
- Ansari MY
- Antas P
- Antebi A
- Antón Z
- Anwar T
- Apetoh L
- Apostolova N
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- Araya J
- Araújo WL
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- Arias E
- Arikkath J
- Arimoto H
- Ariosa AR
- Armstrong-James D
- Arnauné-Pelloquin L
- Aroca A
- Arroyo DS
- Arsov I
- Artero R
- Arévalo M-A
- Asaro DML
- Aschner M
- Ashrafizadeh M
- Ashur-Fabian O
- Atanasov AG
- Au AK
- Auberger P
- Auner HW
- Aurelian L
- Autelli R
- Avagliano L
- Aveic S
- Aveleira CA
- Avin-Wittenberg T
- Aydin Y
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- Ayyadevara S
- Azzopardi M
- Baba M
- Backer JM
- Backues SK
- Bae D-H
- Bae O-N
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- Baehrecke EH
- Baek A
- Baek S-H
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- Bagetta G
- Bagniewska-Zadworna A
- Bai H
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- Bai X
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- Baksi S
- Balazadeh S
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- Baldari CT
- Balduini W
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- Bandopadhyay R
- Banerjee S
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- Bao Y
- Baptista MS
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- Batten I
- Baulieu EE
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- Beaumatin F
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- Benbrook DM
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- Benito-Cuesta I
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- Berchtold MW
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- Bergamaschi D
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- Berliocchi L
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- Besirli CG
- Besteiro S
- Betin VM
- Beyaert R
- Bezbradica JS
- Bhaskar K
- Bhatia-Kissova I
- Bhattacharya R
- Bhattacharya S
- Bhattacharyya S
- Bhuiyan MS
- Bhutia SK
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- Biden TJ
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- Billes VA
- Binart N
- Bincoletto C
- Birgisdottir AB
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- Bornhauser BC
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- Bourdenx M
- Bourgeois B
- Bourke NM
- Bousquet G
- Boya P
- Bozhkov PV
- Bozi LHM
- Bozkurt TO
- Brackney DE
- Brand-Saberi B
- Brandts CH
- Braun RJ
- Braus GH
- Bravo-Sagua R
- Bravo-San Pedro JM
- Brest P
- Bringer M-A
- Briones-Herrera A
- Broaddus VC
- Brodersen P
- Brodsky JL
- Brody SL
- Bronson PG
- Bronstein JM
- Brown CN
- Brown RE
- Brum PC
- Brumell JH
- Brunetti-Pierri N
- Bruno D
- Bryson-Richardson RJ
- Bucci C
- Buch S
- Buchan JR
- Buchrieser C
- Buckingham EM
- Budak H
- Budini M
- Bueno M
- Buitrago-Molina LE
- Bultynck G
- Burada F
- Buraschi S
- Burgoyne JR
- Burón MI
- Bustos V
- Butturini E
- Byrd A
- Bánréti Á
- Büttner S
- Cabas I
- Cabrera-Benitez S
- Cadwell K
- Cai J
- Cai L
- Cai Q
- Cairó M
- Calbet JA
- Caldwell GA
- Caldwell KA
- Call JA
- Calvani R
- Calvo AC
- Calvo-Rubio Barrera M
- Camara NO
- Camonis JH
- Camougrand N
- Campanella M
- Campbell EM
- Campbell-Valois F-X
- Campello S
- Campesi I
- Campos JC
- Camuzard O
- Cancino J
- Candido de Almeida D
- Canesi L
- Caniggia I
- Canonico B
- Cantí C
- Cao B
- Caraglia M
- Caramés B
- Carchman EH
- Cardenal-Muñoz E
- Cardenas C
- Cardenas L
- Cardoso SM
- Carew JS
- Carle GF
- Carleton G
- Carloni S
- Carmona-Gutierrez D
- Carneiro LA
- Carnevali O
- Carosi JM
- Carra S
- Carrier A
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- Carroll B
- Carter AB
- Carvalho AN
- Casanova M
- Casas C
- Casas J
- Cassioli C
- Castillo EF
- Castillo K
- Castillo-Lluva S
- Castoldi F
- Castori M
- Castro AF
- Castro-Caldas M
- Castro-Hernandez J
- Castro-Obregon S
- Catz SD
- Cavadas C
- Cavaliere F
- Cavallini G
- Cavinato M
- Cayuela ML
- Cebollada Rica P
- Cecarini V
- Cecconi F
- Cechowska-Pasko M
- Cenci S
- Ceperuelo-Mallafré V
- Cerqueira JJ
- Cerutti JM
- Cervia D
- Cetintas VB
- Cetrullo S
- Chae H-J
- Chagin AS
- Chai C-Y
- Chakrabarti G
- Chakrabarti O
- Chakraborty T
- Chakraborty T
- Chami M
- Chamilos G
- Chan DW
- Chan ED
- Chan EYW
- Chan H
- Chan HH
- Chan HYE
- Chan MTV
- Chan YS
- Chandra PK
- Chang C
- Chang C-P
- Chang H-C
- Chang K
- Chao J
- Chapman T
- Charlet-Berguerand N
- Chatterjee S
- Chaube SK
- Chaudhary A
- Chauhan S
- Chaum E
- Checler F
- Cheetham ME
- Chen C-S
- Chen G-C
- Chen J-F
- Chen L
- Chen L
- Chen LL
- Chen M
- Chen M-K
- Chen N
- Chen Q
- Chen R-H
- Chen S
- Chen W
- Chen W
- Chen X
- Chen X-M
- Chen X-W
- Chen Y
- Chen Y
- Chen Y
- Chen Y-G
- Chen Y-J
- Chen Y-Q
- Chen Z
- Chen Z
- Chen Z
- Chen Z-H
- Chen ZJ
- Chen ZS
- Cheng H
- Cheng J
- Cheng S-Y
- Cheng W
- Cheng X
- Cheng X-T
- Cheng Y
- Cheng Z
- Cheong H
- Cheong JK
- Chernyak BV
- Cherry S
- Cheung CFR
- Cheung CHA
- Cheung K-H
- Chevet E
- Chi RJ
- Chiang AKS
- Chiaradonna F
- Chiarelli R
- Chiariello M
- Chica N
- Chiocca S
- Chiong M
- Chiou S-H
- Chiramel AI
- Chiurchiù V
- Cho D-H
- Choe S-K
- Choi AMK
- Choi ME
- Choudhury KR
- Chow NS
- Chu CT
- Chua JJE
- Chua JP
- Chung H
- Chung KP
- Chung S
- Chung S-H
- Chung Y-L
- Cianfanelli V
- Ciechomska IA
- Cifuentes M
- Cinque L
- Cirak S
- Cirone M
- Clague MJ
- Clarke R
- Clementi E
- Coccia EM
- Codogno P
- Cohen E
- Cohen MM
- Colasanti T
- Colasuonno F
- Colbert RA
- Colell A
- Coll NS
- Collins MO
- Colombo MI
- Colón-Ramos DA
- Combaret L
- Comincini S
- Cominetti MR
- Consiglio A
- Conte A
- Conti F
- Contu VR
- Cookson MR
- Coombs KM
- Coppens I
- Corasaniti MT
- Cordes N
- Corkery DP
- Cortese K
- Costa MDC
- Costantino S
- Costelli P
- Coto-Montes A
- Crack PJ
- Crespo JL
- Criollo A
- Crippa V
- Cristofani R
- Csizmadia T
- Cuadrado A
- Cui B
- Cui J
- Cui Y
- Cui Y
- Culetto E
- Cumino AC
- Cybulsky AV
- Czaja MJ
- Czuczwar SJ
- D'Adamo S
- D'Amelio M
- D'Arcangelo D
- D'Lugos AC
- D'Orazi G
- da Silva JA
- Dafsari HS
- Dagda RK
- Dagdas Y
- Daglia M
- Dai X
- Dai Y
- Dai Y
- Dal Col J
- Dalhaimer P
- Dalla Valle L
- Dallenga T
- Dalmasso G
- Damme M
- Dando I
- Dantuma NP
- Darling AL
- Das H
- Dasarathy S
- Dasari SK
- Dash S
- Daumke O
- Dauphinee AN
- Davies JS
- Davis RJ
- Davis T
- Dayalan Naidu S
- De Amicis F
- De Bosscher K
- De Felice F
- De Franceschi L
- De Leonibus C
- de Mattos Barbosa MG
- De Meyer GRY
- De Milito A
- De Nunzio C
- De Palma C
- De Santi M
- De Virgilio C
- De Zio D
- Debnath J
- DeBosch BJ
- Decuypere J-P
- Deehan MA
- Deflorian G
- DeGregori J
- Dehay B
- Del Rio G
- Delaney JR
- Delbridge LMD
- Delorme-Axford E
- Delpino MV
- Demarchi F
- Dembitz V
- Demers ND
- Deng H
- Deng Z
- Dengjel J
- Dent P
- Denton D
- DePamphilis ML
- Der CJ
- Deretic V
- Descoteaux A
- Devis L
- Devkota S
- Devuyst O
- Dewson G
- Dharmasivam M
- Dhiman R
- di Bernardo D
- Di Cristina M
- Di Domenico F
- Di Fazio P
- Di Fonzo A
- Di Guardo G
- Di Guglielmo GM
- Di Leo L
- Di Malta C
- Di Nardo A
- Di Rienzo M
- Di Sano F
- Diallinas G
- Diao J
- Diaz-Araya G
- Dickinson JM
- Diederich M
- Dieudé M
- Dikic I
- Ding S
- Ding W-X
- Dini L
- Dinic M
- Dinić J
- Dinkova-Kostova AT
- Dionne MS
- Distler JHW
- Diwan A
- Dixon IMC
- Djavaheri-Mergny M
- Dobrinski I
- Dobrovinskaya O
- Dobrowolski R
- Dobson RCJ
- Dokmeci Emre S
- Donadelli M
- Dong B
- Dong X
- Dong XC
- Dong Z
- Dorn Ii GW
- Dotsch V
- Dou H
- Dou J
- Dowaidar M
- Dridi S
- Drucker L
- du Toit A
- Du A
- Du C
- Du G
- Du H-N
- Du L-L
- Duan S-B
- Duan X
- Duarte SP
- Dubrovska A
- Dunlop EA
- Dupont N
- Durán RV
- Dwarakanath BS
- Dyshlovoy SA
- Dávila VA
- Díaz-Laviada I
- Ebrahimi-Fakhari D
- Eckhart L
- Edelstein CL
- Efferth T
- Eftekharpour E
- Eichinger L
- Eid N
- Eisenberg T
- Eissa NT
- Eissa S
- Ejarque M
- El Andaloussi A
- El-Hage N
- El-Naggar S
- El-Shafey ES
- Eleuteri AM
- Elgendy M
- Eliopoulos AG
- Elizalde MM
- Elks PM
- Elsasser H-P
- Elsherbiny ES
- Emerling BM
- Emre NCT
- Eng CH
- Engedal N
- Engelbrecht A-M
- Engelsen AST
- Enserink JM
- Escalante R
- Esclatine A
- Escobar-Henriques M
- Eskelinen E-L
- Espert L
- Eusebio M-O
- Fabrias G
- Fabrizi C
- Facchiano A
- Facchiano F
- Fadeel B
- Fader C
- Faesen AC
- Fairlie WD
- Falcó A
- Falkenburger BH
- Fan D
- Fan J
- Fan Y
- Fang EF
- Fang Y
- Fang Y
- Fanto M
- Farfel-Becker T
- Faure M
- Fazeli G
- Fedele AO
- Feldman AM
- Feng D
- Feng J
- Feng L
- Feng W
- Feng Y
- Feng Y
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- Zientara-Rytter K
- Zimmermann CM
- Ziviani E
- Zoladek T
- Zong W-X
- Zorov DB
- Zorzano A
- Zou W
- Zou Z
- Zou Z
- Zuryn S
- Zwerschke W
- Álvarez ÉMC
- Ávalos Y
- Önal G
- Üstün S
- Čolić M
- Đokić J
- Žerovnik E
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field
Diminishing benefits of urban living for children and adolescents’ growth and development
- Author
- Abarca-Gómez L
- Abdeen ZA
- Abdrakhmanova S
- Abdul Rahim HF
- Abdurrahmonova Z
- Abril GL
- Abu-Rmeileh NM
- Acosta-Cazares B
- Adam I
- Adamczyk M
- Adams RJ
- Adu-Afarwuah S
- Aekplakorn W
- Afsana K
- Afzal S
- Agbor VN
- Agdeppa IA
- Aghazadeh-Attari J
- Aguenaou H
- Aguilar-Salinas CA
- Agyemang C
- Ahmad MH
- Ahmad NA
- Ahmadi A
- Ahmadi N
- Ahmadi N
- Ahmed I
- Ahmed SH
- Ahrens W
- Aitmurzaeva G
- Ajlouni K
- Al Hourani HM
- Al Qaoud NM
- Al-Hazzaa HM
- Al-Lahou B
- Al-Raddadi R
- Alarouj M
- AlBuhairan F
- AlDhukair S
- Aldwairji MA
- Alexius S
- Ali MM
- Alkandari A
- Alkerwi A
- Alkhatib BM
- Allin K
- Alvarez-Pedrerol M
- Aly E
- Amarapurkar DN
- Amoah J
- Amougou N
- Amouyel P
- Andersen LB
- Anderssen SA
- Androutsos O
- Anjana RM
- Ansari-Moghaddam A
- Anufrieva E
- Aounallah-Skhiri H
- Araújo J
- Ariansen I
- Aris T
- Arku RE
- Arlappa N
- Aryal KK
- Aseffa N
- Aspelund T
- Assah FK
- Assembekov B
- Assunção MCF
- Aung MS
- Auvinen J
- Avdičová M
- Avi S
- Azevedo A
- Azimi-Nezhad M
- Azizi F
- Azmin M
- Babu BV
- Baharudin A
- Bahijri S
- Bakacs M
- Baker JL
- Balakrishna N
- Balanova Y
- Bamoshmoosh M
- Banach M
- Banegas JR
- Bao TQ
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- Baran R
- Barbagallo CM
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- Bastos JLD
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- Batista AP
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- Baur LA
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- Bennett JE
- Bentham J
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- Bergh IH
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- Bernotiene G
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- Beutel ME
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- Bhutta ZA
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- Tornaritis MJ
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- Traissac P
- Tran TT-H
- Tremblay MS
- Triantafyllou A
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- Trichopoulou A
- Trinh OTH
- Trivedi A
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- van der Schouw YT
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- van Valkengoed IGM
- Vanderschueren D
- Vanuzzo D
- Varbo A
- Varela-Moreiras G
- Vargas LN
- Varona-Pérez P
- Vasan SK
- Vasques DG
- Vega T
- Veidebaum T
- Velasquez-Melendez G
- Velika B
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- Veronesi G
- Verschuren WMM
- Victora CG
- Viegi G
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- Vrkic TZ
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- Wambiya EOA
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- Wang YX
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- Westbury LD
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- Widyahening IS
- Wild PS
- Wilks RJ
- Willeit J
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- Wirth JP
- Więcek A
- Wojciech R
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- Wong TY
- Wong-McClure RA
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- Wu H-Y
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- Wu LJ
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- Wyszyńska J
- Xu H
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- Yaacob NA
- Yamborisut U
- Yan W
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- Yang X
- Yang Y
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- Yasuharu T
- Yiallouros PK
- Yngve A
- Yoosefi M
- Yoshihara A
- You QS
- You S-L
- Younger-Coleman NO
- Yu Y
- Yu Y-L
- Yusof SM
- Yusoff AF
- Yusoff MFM
- Zaccagni L
- Zafiropulos V
- Zainuddin AA
- Zakavi SR
- Zamani F
- Zambon S
- Zampelas A
- Zamrazilová H
- Zapata ME
- Zargar AH
- Zaw KK
- Zayed AA
- Zdrojewski T
- Zejglicova K
- Zeng Y
- Zhang L
- Zhang Z-Y
- Zhao D
- Zhao M-H
- Zhao W
- Zhecheva YV
- Zhen S
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- Łuszczki E
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
AbstractOptimal growth and development in childhood and adolescence is crucial for lifelong health and well-being1–6. Here we used data from 2,325 population-based studies, with measurements of height and weight from 71 million participants, to report the height and body-mass index (BMI) of children and adolescents aged 5–19 years on the basis of rural and urban place of residence in 200 countries and territories from 1990 to 2020. In 1990, children and adolescents residing in cities were taller than their rural counterparts in all but a few high-income countries. By 2020, the urban height advantage became smaller in most countries, and in many high-income western countries it reversed into a small urban-based disadvantage. The exception was for boys in most countries in sub-Saharan Africa and in some countries in Oceania, south Asia and the region of central Asia, Middle East and north Africa. In these countries, successive cohorts of boys from rural places either did not gain height or possibly became shorter, and hence fell further behind their urban peers. The difference between the age-standardized mean BMI of children in urban and rural areas was <1.1 kg m–2 in the vast majority of countries. Within this small range, BMI increased slightly more in cities than in rural areas, except in south Asia, sub-Saharan Africa and some countries in central and eastern Europe. Our results show that in much of the world, the growth and developmental advantages of living in cities have diminished in the twenty-first century, whereas in much of sub-Saharan Africa they have amplified.</jats:p
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