Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

Although the MYC oncogene has been implicated in cancer, a systematic assessment of alterations of MYC, related transcription factors, and co-regulatory proteins, forming the proximal MYC network (PMN), across human cancers is lacking. Using computational approaches, we define genomic and proteomic features associated with MYC and the PMN across the 33 cancers of The Cancer Genome Atlas. Pan-cancer, 28% of all samples had at least one of the MYC paralogs amplified. In contrast, the MYC antagonists MGA and MNT were the most frequently mutated or deleted members, proposing a role as tumor suppressors. MYC alterations were mutually exclusive with PIK3CA, PTEN, APC, or BRAF alterations, suggesting that MYC is a distinct oncogenic driver. Expression analysis revealed MYC-associated pathways in tumor subtypes, such as immune response and growth factor signaling; chromatin, translation, and DNA replication/repair were conserved pan-cancer. This analysis reveals insights into MYC biology and is a reference for biomarkers and therapeutics for cancers with alterations of MYC or the PMN. We present a computational study determining the frequency and extent of alterations of the MYC network across the 33 human cancers of TCGA. These data, together with MYC, positively correlated pathways as well as mutually exclusive cancer genes, will be a resource for understanding MYC-driven cancers and designing of therapeutics

The clinical efficacy of amlodipine treatment in ischemic heart disease

We assessed the efficacy of amlodipine treatment on 20 patients with stable angina pectoris. Amlodipine reduced the number of anginal attacks, nitroglycerine consumption, and ameliorated a subjective score of well-being. Amlodipine also increased duration of exercise, time to angina, time to ST segment changes, and decreased the duration as well as the extent of ST depression. We conclude that calcium chanenl blocker amlodipine with once daily dosage and long plasma half-life is effective in the treatment of ischemic heart disease

Pulmonary venous obstruction from left atrial thrombus in a patient with pervious mitral valve replacement PULMONER VENLERI TIKAYAN SOL ATRIAL TROMBUS KITLELERI SAPTANAN MITRAL KAPAK REPLASMANI YAPILMIS BIR VAKA

We encountered a patient with obliteration of pulmonary venous inflow with left atrial thrombosis diagnosed by transesophageal echocardiography

Niveles de nitrógeno y su fraccionamiento en el cultivo del gladiolo para suelos Ferralíticos Rojos Nitrogen levels and their fractioning in gladiolus cultivation for Ferralitic Red soils

El objetivo del presente estudio fue evaluar niveles crecientes de nitrógeno y momentos de aplicación del fertilizante nitrogenado en el cultivo del gladiolo. La experiencia se desarrolló en el Instituto de Investigaciones Hortícolas Liliana Dimitrova (Municipio de Quivicán, La Habana, Cuba), en un suelo Ferralítico Rojo, entre los meses de octubre y febrero de las campañas 2004/2005 y 2005/2006. Se evaluaron los componentes de la calidad de las espigas y del material de plantación, así como el efecto de los tratamientos en el estado nutricional de la planta y en la vida en anaquel de las espigas. No se observaron diferencias entre las dosis de nitrógeno y los momentos de aplicación del fertilizante en las variables de calidad de la espiga y del cormo. No obstante, con la variante 70 kg ha-1 de N, aplicada ½ en plantación y ½ a los 60 días posteriores, se logra un mayor porcentaje de espigas ubicadas en las categorías comerciales y un menor número de tallos florales de calidad inferior. En cuanto al estado nutricional de la plantación, existe una relación positiva entre los niveles y los contenidos foliares de nitrógeno aplicados.<br>The objective of this study was to evaluate growing nitrogen levels and application time of the nitrogen fertilizer in gladiolus cultivation. The experiment was carried out at Instituto de Investigaciones Hortículas Liliana Dimitrova (in the Municipality of Quivicán, La Habana, Cuba) in an Oxisol soil, from October to February of the 2004-2005 and 2005-2006 crop seasons. The quality components of the spikes and plant material were evaluated, as well as the effect of the treatments on the plant nutritional state and the shelf life of the spikes. No differences between nitrogen doses and fertilizer application time in quality variables of spikes and corms were observed. Nevertheless, with the variant 70 kg ha-1 of N, one half applied in plantation and the other half applied 60 days later, a higher spike percentage of commercial categories and a lesser number of stems of inferior quality were obtained. As for the plantation nutritional state, there is a positive relation between the applied nitrogen levels and the foliar content of this element