258 research outputs found

    SEDIMENTOLOGICAL AND GEOPHYSICAL OBSERVATIONS IN THE DELTA PLAIN OF SELINOUS RIVER, ANCIENT HELIKE, NORTHERN PELOPONNESUS GREECE

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    Fine and coarse grained lithofacies and depositional environments were distinguished in Selinous River delta plain, from sediment cores using an Eijkelkamp percussion corer with barrel windows. The sedimentary sequence of deltaic plain deposits of Selinous River mostly consists of fine lithofacies interbedded occasionally with conglomerate facies. Fine grained lithofacies based on sediment types, structure, color, as well as contact depths and bed characteristics were interpreted as floodplain, crevasse splay, back swamp / fresh water swamp, permanent shallow fresh water lake and ephemeral fresh water lake facies. The coarse grained lithofacies consists of pebble - conglomerates and were interpreted as paleochannels. The Time-Domain Electromagnetic technique, (TEM) was applied in order to define the spatial distribution of lenses of conglomerates, palaeochannels and fine grained sedimentary material to be recognised, at a depth up to 35m. Both the sedimentological and geophysical approaches, in combination with the available geological and geomorphological data of the area, can provide information about the evolution, existence and the geometry of paleochannels of the Selinous River flood plain, and the paleoenvironment of the area of the ancient Helike

    Palaeocurrent directions as an indicator of Pindos foreland evolution (central and southern part), Western Greece

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    In order to estimate the palaeoflow direction of the submarine fans, deposited in the Internal Ionian subbasin of the Pindos Foreland, fifty-one positions along the sub-basin were selected and measurements of palaeocurrents indicators such as flute and groove marks were taken. In the studied area the main palaeoflow direction of turbidites was axial, from south to north in the southern part, and from north to south in the northern part. A minor westward palaeoflow direction is also present. These palaeoflow directions were influenced mainly by the regional tectonic activity, such as internal thrusting (Gavrovo Thrust) and differential activity of the Pindos Thrust which subdivided Pindos foreland into narrow linear sub-basins

    Recruitment of ubiquitin-activating enzyme UBA1 to DNA by poly(ADP-ribose) promotes ATR signalling

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    The DNA damage response (DDR) ensures cellular adaptation to genotoxic insults. In the crowded environment of the nucleus, the assembly of productive DDR complexes requires multiple protein modifications. How the apical E1 ubiquitin activation enzyme UBA1 integrates spatially and temporally in the DDR remains elusive. Using a human cell-free system, we show that poly(ADP-ribose) polymerase 1 promotes the recruitment of UBA1 to DNA. We find that the association of UBA1 with poly(ADP-ribosyl)ated protein–DNA complexes is necessary for the phosphorylation replication protein A and checkpoint kinase 1 by the serine/threonine protein kinase ataxia-telangiectasia and RAD3-related, a prototypal response to DNA damage. UBA1 interacts directly with poly(ADP-ribose) via a solvent-accessible and positively charged patch conserved in the Animalia kingdom but not in Fungi. Thus, ubiquitin activation can anchor to poly(ADP-ribose)-seeded protein assemblies, ensuring the formation of functional ataxia-telangiectasia mutated and RAD3-related-signalling complexes
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