C/Cフクゴウザイリョウ ノ チョウコウオンカ ニオケル キョウドジンセイ

Mechanical properties of carbon fiber reinforced carbon (C/C) composites, fabricated by the preformed yarn method, were studied at elevated temperature up to 2300℃ in vacuum. Various mechanical tests including tensile, flexural, interlamina shear and fracture toughness tests were carried out to evaluate temperature dependence of strength, Young\u27s modulus and fracture toughness for three kinds of laminate C/C composites with uni-directional, 0°/90° and O°/90°/±45° fiber orientations. The failure processes of C/C composites were examined mainly focused on the influence of "transverse-cracks", which bad introduced during processing

Inhibitory effect of a new steroidal saponin, OSW-1, on ovarian functions in rats

1. This study was undertaken to determine the effects of OSW-1 (3β, 16β, 17α-trihydroxycholest-5-en-22-one 16-O-(2-O-4-methoxybenzoyl-β-D-xylopyranosyl)-(1→3)-(2-O-acetyl-α-L-arabinopyranoside)) on the pituitary-ovarian system and the functions of aortic smooth muscle. 2. A single s.c. injection of OSW-1 (9 μg kg(−1)) on the morning of pro-oestrus inhibited the occurrence of the expected next pro-oestrus, whereas administration of OSW-1 at a dose of 4.5 μg kg(−1) did not affect the oestrous cycle. OSW-1 treatment on the day of dioestrus-l did not affect the oestrous cycle. 3. At doses of 4.5 and 9 μg kg(−1) OSW-1, the serum oestradiol (E(2)) levels at the expected next pro-oestrus were significantly lower than in control (pro-oestrus). The serum luteinizing hormone (LH) levels 4 days after 9 μg kg(−1) OSW-1 treatment were also markedly lower than those of control. OSW-1 (4.5 μg kg(−1)) did not affect the levels of inhibin, progesterone and gonadotrophins on the same day. 4. OSW-1 did not inhibit the preovulatory LH surge which occurs on the afternoon of pro-oestrus day. 5. The expression of mRNA coding for the cholesterol side chain cleavage cytochrome P-450 (p450scc), an ovarian steroidal limiting enzyme, was suppressed at 24 and 96 h after OSW-1 treatment. 6. Administration of OSW-1 (9 μg kg(−1)) tended to reduce the relaxation of isolated thoracic aorta ring preparations induced by acetylcholine, while there was no difference in the relaxation induced by sodium nitroprusside. 7. Our results show that OSW-1 inhibits ovarian E(2) secretion and that the decrease in E(2) secretion may contribute to its effects on the oestrous cycle and the sensitivity of the thoracic aorta to relaxation. The decrease in the levels of ovarian steroids induced by OSW-1 may be due to its direct inhibitory action on the gene expression of the steroidal enzyme and on the proliferation of granulosa cells in the ovary

Additional file 2: Figure S1. of The prognostic value of serum CA 19-9 for patients with advanced lung adenocarcinoma

Scatter-plot of serum CA 19-9 and CYFRA 21-1 levels. (JPG 394 kb