154 research outputs found
知的障害児の言語指導 : 育成を目指す資質・能力を踏まえた知的障害児の国語教育
知的障害特別支援学校の各教科は、従来、小学校等の各教科等とは異なり、知的障害の特徴や学習上の特性等に応じた目標や内容が示され、その障害に応じ、生活を重視した指導・支援が行われてきている。平成29年4月に告示された特別支援学校小学部・中学部学習指導要領(以下、新学習指導要領と表記)では、そのことを踏襲しつつ、小学校等の目標や内容等との連続性や関連性を整理し、育成を目指す資質・能力の三つの柱に基づき、目標や内容が構造的に示されている。ここでは、知的障害児教育における言語指導の重要性について改めて考察するとともに、育成を目指す資質・能力の中核となる言葉(国語)を取り上げ、育成を目指す資質・能力を踏まえた知的障害児の国語教育はどうあればよいかについて言及する。Subjects which composes the curriculum in special needs school for children with intellectual disabilities is different from subjects for an elementary school. It focuses on building up children’s life experience. This report examined teaching of Japanese language based upon the capabilities required in the future for children with intellectual disabilities
障害のある子どもと障害のない子どもが可能な限り共に教育を受けられる学びの在り方2:国際バカロレアの「インクルーシブな教育」と「教育のユニバーサルデザイン」の視点から
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「発達障害のある子どもの理解と支援」:錦江台まちづくり協議会福祉部会と連携した研修会の開催
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保護者の想いを生かしたPTA活動:肢体不自由特別支援学校等のPTA活動の在り方及び学校の安全管理・安全教育と連携した家庭・PTAの防災への備えについて
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Occurrence of silk stitch abscess after surgery in patients with oral squamous cell carcinoma
Objectives: To elucidate the predisposing factors and clinical characteristics related to the occurrence of stitch
abscess after surgery in patients with oral squamous cell carcinoma (SCC).
Patients
and
Methods: The subjects were 232 patients who underwent excision and/or reconstruction and/or neck
dissection for oral SCC using silk sutures for high ligation of the blood vessels. Detection rates and characteristics of patients with stitch abscess were retrospectively evaluated by comparing patients with and without stitch
abscesses after surgery diagnosed by ultrasonography and findings of various modalities in 232 patients. Several
echogenic dots with subtle acoustic shadows in a hypoechoic mass were identified as the characteristic findings of
stitch abscess on US. The patient groups with and without stitch abscess were compared with respect to various
factors to identify those that predispose to the occurrence of stitch abscess. The factors analyzed included patients'
sex and age, chemotherapy treatment, radiotherapy treatment, the presence of a history of allergy, and blood test
results.
Results: A significant correlation was found between the occurrence of stitch abscess and age, liver function
abnormalities on blood tests, and the presence of a history of allergy. Multiple stitch abscesses clearly tended to
occur more often than single ones in patients with stitch abscess.
Conclusions: The occurrence of stitch abscesses was related to age, liver dysfunction, and/or the presence of allergies. When diagnosing stitch abscess, the occurrence of multiple stitch abscesses is important
Arthroscopic, histological and MRI analyses of cartilage repair after a minimally invasive method of transplantation of allogeneic synovial mesenchymal stromal cells into cartilage defects in pigs
AbstractBackground aimsTransplantation of synovial mesenchymal stromal cells (MSCs) may induce repair of cartilage defects. We transplanted synovial MSCs into cartilage defects using a simple method and investigated its usefulness and repair process in a pig modelMethodsThe chondrogenic potential of the porcine MSCs was compared in vitro. Cartilage defects were created in both knees of seven pigs, and divided into MSCs treated and non-treated control knees. Synovial MSCs were injected into the defect, and the knee was kept immobilized for 10min before wound closure. To visualize the actual delivery and adhesion of the cells, fluorescence-labeled synovial MSCs from transgenic green fluorescent protein (GFP) pig were injected into the defect in a subgroup of two pigs. In these two animals, the wounds were closed before MSCs were injected and observed for 10min under arthroscopic control. The defects were analyzed sequentially arthroscopically, histologically and by magnetic resonance imaging (MRI) for 3 monthsResultsSynovial MSCs had a higher chondrogenic potential in vitro than the other MSCs examined. Arthroscopic observations showed adhesion of synovial MSCs and membrane formation on the cartilage defects before cartilage repair. Quantification analyses for arthroscopy, histology and MRI revealed a better outcome in the MSC-treated knees than in the non-treated control kneesConclusionsLeaving a synovial MSC suspension in cartilage defects for 10min made it possible for cells to adhere in the defect in a porcine cartilage defect model. The cartilage defect was first covered with membrane, then the cartilage matrix emerged after transplantation of synovial MSCs
血管内腔側から流入する頚動脈プラーク内新生血管の造影超音波及び病理学的検討
Objective: This study was aimed at assessing intraplaque neovessels, focusing on neovascularization from the vascular luminal side using contrast-enhanced ultrasound (CEUS) and determining that this contrast effect indicates that the neovessel is connected to the vessel lumen histopathologically. Whether plaque vulnerability can be assessed more accurately was also investigated. Methods: We enrolled consecutive patients with internal carotid artery stenosis who underwent carotid endarterectomy (CEA) and pre-operative CEUS with perflubutane of the carotid arteries. We graded the contrast effect semi-quantitatively from the vascular luminal and adventitial sides. We compared the contrast effect with the pathological findings, especially the neovascularization of the CEA specimens. Results: In total, 68 carotid arterial atheromatous plaques (47 symptomatic) were analyzed. Symptomatic plaques were significantly correlated with stronger contrast effects from the luminal side than from the adventitial side (p = 0.0095). Microbubbles from the luminal side appeared to flow mainly into the plaque shoulder. The contrast effect value for the plaque shoulder and neovessel density were significantly correlated (ρ = 0.35, p = 0.031). Neovessel density was significantly higher in symptomatic than in asymptomatic plaques (56.2 ± 43.7/mm2 and 18.1 ± 15.2/mm2, respectively, p < 0.0001). Serial histological sections of CEA specimens in a symptomatic plaque with a strong contrast effect from the luminal side revealed multiple neovessels fenestrated to the vessel lumen with endothelial cells, consistent with the CEUS findings. Conclusion: Contrast-enhanced ultrasound can be used to evaluate neovessels originating from the luminal side, histopathologically confirmed in serial sections. Symptomatic vulnerable plaque is correlated more significantly with intraplaque neovascularization from the luminal side than with neovascularization from the adventitia.本文は発行元が定める公開猶予期間終了後に公開
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