432 research outputs found
Physics potential of future long baseline neutrino oscillation experiments with KEK-JAERI HIPA
We study physics potential of Very Long Base-Line (VLBL) Neutrino-Oscillation
Experiments with the High Intensity Proton Accelerator, which will be completed
by the year 2007 in Tokai-village, Japan. As a target, a 100 kton-level
water-erenkov detector is considered at 2,100 km away. Assuming
the pulsed narrow-band beams, we study sensitivity of such
experiments to the neutrino mass hierarchy, the mass-squared differences, one
CP phase and three angles of the lepton-flavor-mixing matrix. We find that
experiments at a distance 2,100 km can determine the neutrino mass hierarchy if
the mixing matrix element is not too small. The CP phase and
can be constrained if the large-mixing-angle solution of the
solar-neutrino deficit is realized.Comment: 6 pages, LaTeX, Talk given at 5th KEK Topical Conference (KEKTC5),
KEK, Tsukuba, Japan, November 200
Function and Characteristics of PINK1 in Mitochondria
Mutations in phosphatase and tensin homologue-induced kinase 1 (PINK1) cause recessively inherited Parkinson’s disease, a neurodegenerative disorder linked to mitochondrial dysfunction. Studies support the notion of neuroprotective roles for the PINK1, as it protects cells from damage-mediated mitochondrial dysfunction, oxidative stress, and cell apoptosis. PARL is a mitochondrial resident rhomboid serine protease, and it has been reported to mediate the cleavage of the PINK1. Interestingly, impaired mitophagy, an important autophagic quality control mechanism that clears the cells of damaged mitochondria, may also be an underlying mechanism of disease pathogenesis in patients for Parkinson’s disease with the PARL mutations. Functional studies have revealed that PINK1 recruits Parkin to mitochondria to initiate the mitophagy. PINK1 is posttranslationally processed, whose level is definitely regulated in healthy steady state of mitochondria. As a consequence, PINK1 plays a pivotal role in mitochondrial healthy homeostasis
Distance to G14.33-0.64 in the Sagittarius Spiral Arm: H2O Maser Trigonometric Parallax with VERA
We report on trigonometric parallax measurements for the Galactic star
forming region G14.33-0.64 toward the Sagittarius spiral arm. We conducted
multi-epoch phase-referencing observations of an H2O maser source in
G14.33-0.64 with the Japanese VLBI array VERA. We successfully detected a
parallax of 0.893+/-0.101 mas, corresponding to a source distance of
1.12+/-0.13 kpc, which is less than half of the kinematic distance for
G14.33-0.64. Our new distance measurement demonstrates that the Sagittarius arm
lies at a closer distance of ~1 kpc, instead of previously assumed ~2-3 kpc
from kinematic distances. The previously suggested deviation of the Sagittarius
arm toward the Galactic center from the symmetrically fitted model (Taylor &
Cordes 1993) is likely due to large errors of kinematic distances at low
galactic longitudes. G14.33-0.64 most likely traces the near side of the
Sagittarius arm. We attempted fitting the pitch angle of the arm with other
parallax measurements along the arm, which yielded two possible pitch angles of
i=34.7+/-2.7 degrees and i=11.2+/-10.5 degrees. Our proper motion measurements
suggest G14.33-0.64 has no significant peculiar motion relative to the
differential rotation of the Galaxy (assumed to be in a circular orbit),
indicating that the source motion is in good agreement with the Galactic
rotation.Comment: 14 pages, 7 figures, to appear in PASJ Vol. 62, No.
Protection against Cancer with Medicinal Herbs via Activation of Tumor Suppressor
Cancer remains a major cause of death, although research is ongoing for the development of more effective drugs. Some herbs have shown potential in preventing the occurrence and/or progression of cancer and other chronic diseases. They are being screened comprehensively to explore the possibility of development of feasible anticancer drugs. However, more information is required about the response to and the molecular target for specific herbs. It seems that there is a relationship between some medicinal herbs and tumor suppressor molecules which protect a cell from cancer. In this paper, we summarize the progress of recent research on herbs, with a particular focus on its anticancer role and molecular mechanisms underlying the cancer prevention property, supporting design for further research in this field
Proteasome-dependent decrease in Akt by growth factors in vascular smooth muscle cells
AbstractAkt is activated by growth factors to regulate various aspects of vascular smooth muscle cell function. Platelet-derived growth factor (PDGF) and insulin-like growth factor-1 activated Akt in vascular smooth muscle cells with a rapid reduction of total Akt protein that lasted for several hours. The downregulation of Akt required phosphatidylinositol 3-kinase activity, but not intrinsic Akt activity. The downregulation of Akt was abrogated by MG-132, a proteasome inhibitor, but not by inhibitors of calpain or cathepsins. Akt was found in ubiquitin immune complex after PDGF treatment. Proteasome-dependent degradation of Akt may provide a counter-regulatory mechanism against overactivation of Akt
- …