Investigation of implantable multichannel biotelemetry systems Semiannual report, Sep. 1966 - Mar. 1967

Techniques for fabrication of multiple-channel physiologically implantable telemetry system

Investigation of implantable multichannel biotelemetry Semiannual report, Mar. - Aug. 1968

Multichannel, physiologically implantable telemetering system for biological measurement

Investigation if implantable multichannel biotelemetry systems Semiannual report, Sep. 1967 - Feb. 1968

Operation and maintenance of multichannel, physiologically implantable telemetering systems for biological measurement

Advanced electronic technology and the design and development of an integral circuit, multi-channel telemetry system for bio-medical applications Final report, Mar. 1966 - Feb. 1969

Application of electronic technology to design and development of integrated circuit, telemetry system for biomedicin

Investigation of implantable multichannel biotelemetry systems Semiannual report, Mar. - Sep. 1967

System design and fabrication methods for multiple channel, physiologically implantable, telemetering system

System design and fabrication technique for multi-channel, physiologically implantable, telemetering systems for biological measurements Semiannual report, Sep. 1968 - Feb. 1969

Ring oscillator and strain gage transmitter development for multichannel biotelemetry syste

Microelectronic bioinstrumentation system

The progess made from April 1973 to June 1974 on a microelectronics bioinstrumentation system is reported and includes data for the following three individual projects: (1) a radio frequency powered implant telemetry system; (2) an ingestible temperature telemeter; and (3) development of pO2 and pH sensors. Proposed activities for continuation of the research for the period September 1, 1974 to August 31, 1975 are also discussed

Solid State Electronics Laboratory Semiannual report, Feb. - Sep. 1969

Design and performance of miniaturized portable heart rate and electrocardiographic monitoring system for prolonged space flight

Osteopontin is a hematopoietic stem cell niche component that negatively regulates stem cell pool size

Stem cells reside in a specialized niche that regulates their abundance and fate. Components of the niche have generally been defined in terms of cells and signaling pathways. We define a role for a matrix glycoprotein, osteopontin (OPN), as a constraining factor on hematopoietic stem cells within the bone marrow microenvironment. Osteoblasts that participate in the niche produce varying amounts of OPN in response to stimulation. Using studies that combine OPN-deficient mice and exogenous OPN, we demonstrate that OPN modifies primitive hematopoietic cell number and function in a stem cell–nonautonomous manner. The OPN-null microenvironment was sufficient to increase the number of stem cells associated with increased stromal Jagged1 and Angiopoietin-1 expression and reduced primitive hematopoietic cell apoptosis. The activation of the stem cell microenvironment with parathyroid hormone induced a superphysiologic increase in stem cells in the absence of OPN. Therefore, OPN is a negative regulatory element of the stem cell niche that limits the size of the stem cell pool and may provide a mechanism for restricting excess stem cell expansion under conditions of niche stimulation