Maximisation of Fundamental Frequency for Continuum Structures using Modal Strain Energy Method

The goal of the structural engineer is to maximise this fundamental frequency of continuum structures. The Eigen value analysis has been an important area of research for a structural engineer during the past few years.  The fundamental frequency of any structure is the most important parameter useful in the design of a structure. Several algorithms have been proposed in the past to solve for the Eigen frequencies. The focus of this study is to apply modal strain energy method to maximise the fundamental frequency.  A basic example of plate structure has been studied in detail by varying the input parameters. The results clearly show that the distribution of material can be done effectively to maximise the fundamental frequency.  The present study is the first step towards performing topology optimization of continuum structures and conducting damage detection analysis using eigen frequencies.

Development and Validation of a HPLC Method for Determination of Anastrozole in Tablet Dosage Form

A simple, economic, accurate reverse phase isocratic HPLC method was developed for the quantitation of anastrozole in tablet dosage form. The quantification was carried out using Gracesmart RP18, 5 μ (100 mmx4.6 mm) with UV detected at 215 nm. The elution was achieved isocratically with a mobile phase comprising a mixture of buffer (pH 6.0) and acetonitrile (1:1, v/v). The flow rate was 1.0 mL/min The procedure was validated as per ICH rules for Accuracy, Precision, Detection limit, Linearity, Reproducibility and Quantitation limit. The linearity concentration range was 10-20 mcg/mL with the correlation coefficient of 0.9935. The percentage recovery for Anastrozole was found to be 97.31±2.2%. Limit of detection and limit of quantitation values were found to be 0.351 mcg/mL and 1.053 mcg/mL. The method has been successfully used to analyze commercial solid dosage containing 1mg of anastrozole with good recoveries and proved to be robust