20 research outputs found
More than a century of bathymetric observations and present-day shallow sediment characterization in Belfast Bay, Maine, USA: implications for pockmark field longevity
This paper is not subject to U.S. copyright. The definitive version was published in Geo-Marine Letters 31 (2011): 237-248, doi:10.1007/s00367-011-0228-0.Mechanisms and timescales responsible for
pockmark formation and maintenance remain uncertain,
especially in areas lacking extensive thermogenic fluid
deposits (e.g., previously glaciated estuaries). This study
characterizes seafloor activity in the Belfast Bay, Maine
nearshore pockmark field using (1) three swath bathymetry
datasets collected between 1999 and 2008, complemented
by analyses of shallow box-core samples for radionuclide
activity and undrained shear strength, and (2) historical
bathymetric data (report and smooth sheets from 1872,
1947, 1948). In addition, because repeat swath bathymetry
surveys are an emerging data source, we present a selected
literature review of recent studies using such datasets for
seafloor change analysis. This study is the first to apply the
method to a pockmark field, and characterizes macro-scale
(>5 m) evolution of tens of square kilometers of highly
irregular seafloor. Presence/absence analysis yielded no
change in pockmark frequency or distribution over a 9-year
period (1999–2008). In that time pockmarks did not
detectably enlarge, truncate, elongate, or combine. Historical
data indicate that pockmark chains already existed in
the 19th century. Despite the lack of macroscopic changes
in the field, near-bed undrained shear-strength values of
less than 7 kPa and scattered downcore 137Cs signatures
indicate a highly disturbed setting. Integrating these
findings with independent geophysical and geochemical
observations made in the pockmark field, it can be
concluded that (1) large-scale sediment resuspension and
dispersion related to pockmark formation and failure do not
occur frequently within this field, and (2) pockmarks can
persevere in a dynamic estuarine setting that exhibits
minimal modern fluid venting. Although pockmarks are
conventionally thought to be long-lived features maintained
by a combination of fluid venting and minimal sediment
accumulation, this suggests that other mechanisms may be
equally active in maintaining such irregular seafloor
morphology. One such mechanism could be upwelling
within pockmarks induced by near-bed currents.Graduate support for Brothers came from a
Maine Economic Improvement Fund Dissertation Fellowship
Pancreatic cancer biomarkers discovery by surface-enhanced laser desorption and ionization time-of-flight mass spectrometry
Heparin-binding epidermal growth factor-like growth factor suppresses experimental liver fibrosis in mice
Epithelial separation theory for post-tonsillectomy secondary hemorrhage: evidence in a mouse model and potential heparin-binding epidermal growth factor-like growth factor therapy
Survival and proliferation factors of normal and malignant plasma cells.
International audienceSince the first identification of interleukin (IL)-6 as a myeloma cell growth factor by Dr. Kawano's and Dr. Klein's groups 14 years ago, numerous studies have emphasized its major roles in the emergence of malignant plasma cells in vivo and in the generation of normal plasma cells. Four transcription factors control B-cell differentiation into plasma cells. The B-cell transcription factor pax-5 is mainly responsible for a B-cell phenotype, and bcl-6 represses the plasma cell transcription factor blimp-1 and plasma cell differentiation. bcl-6 expression is triggered by CD40 and IL-4 activation. A lack of CD40 and IL-4 activation yields a down-regulation of bcl-6 expression, and IL-6 stimulation yields an up-regulation of blimp-1, mainly through STAT3 activation. Blimp-1 further down-regulates bcl-6 and pax-5 expression and makes plasma cell differentiation possible. IL-6 as well as IL-10 up-regulate XBP-1. XBP-1 is another transcription factor that is involved in plasma cell differentiation and whose gene expression is shut down by pax-5. The plasma cell transcription factors blimp-1 and XBP-1 are up-regulated, and the B-cell transcription factors bcl-6 and pax-5 are down-regulated, in malignant cells compared to B-cells. Apart from the recent identification of these 4 transcription factors, the factors involved in normal plasma cell generation are mostly unknown. Regarding malignant plasma cells, 3 categories of growth factors have been identified: (1) the IL-6 family cytokines, IL-10, and interferon alpha that activate the Janus kinase-signal transducer and activator of transcription (JAK/STAT) and mitogen-activated protein (MAP) kinase pathways; (2) growth factors activating the phosphatidylinositol (PI)-3 kinase/AKT and MAP kinase pathways, unlike the JAK/STAT pathway (insulin-like growth factor 1, hepatocyte growth factor, and members of the epidermal growth factor family able to bind syndecan-1 proteoglycan); and (3) B-cell-activating factor (BAFF) or proliferation-inducing ligand (APRIL) that activate the nuclear factor KB and PI-3 kinase/AKT pathways. BAFF and APRIL bind to BAFF receptor and TACI and are major B-cell survival factors. Recent data indicate that these various growth factors may cooperate to provide optimum signaling because they are localized together and with cytoplasmic transduction elements in caveolinlinked membrane caveolae. The identification of these myeloma cell growth factors and of the associated transduction pathways should provide novel therapeutic targets in multiple myeloma
Radiologists staunchly support patient safety and autonomy, in opposition to the SCOTUS decision to overturn Roe v Wade
Letter to the editor