Warehouse commodity classification from fundamental principles. Part II: Flame heights and flame spread

In warehouse storage applications, it is important to classify the burning behavior of commodities and rank them according to their material flammability for early fire detection and suppression operations. In this study, a preliminary approach towards commodity classification is presented that models the early stage of large-scale warehouse fires by decoupling the problem into separate processes of heat and mass transfer. Two existing nondimensional parameters are used to represent the physical phenomena at the large-scale: a mass transfer number that directly incorporates the material properties of a fuel, and the soot yield of the fuel that controls the radiation observed in the large-scale. To facilitate modeling, a mass transfer number (or B-number) was experimentally obtained using mass-loss (burning rate) measurements from bench-scale tests, following from a procedure that was developed in Part I of this paper. Two fuels are considered: corrugated cardboard and polystyrene. Corrugated cardboard provides a source of flaming combustion in a warehouse and is usually the first item to ignite and sustain flame spread. Polystyrene is typically used as the most hazardous product in large-scale fire testing. The nondimensional mass transfer number was then used to model in-rack flame heights on 6.19.1 m (2030 ft) stacks of 'C' flute corrugated cardboard boxes on rack-storage during the initial period of flame spread (involving flame spread over the corrugated cardboard face only). Good agreement was observed between the model and large-scale experiments during the initial stages of fire growth, and a comparison to previous correlations for in-rack flame heights is included. © 2011 Elsevier Ltd. All rights reserved

Eag and HERG potassium channels as novel therapeutic targets in cancer

Voltage gated potassium channels have been extensively studied in relation to cancer. In this review, we will focus on the role of two potassium channels, Ether à-go-go (Eag), Human ether à-go-go related gene (HERG), in cancer and their potential therapeutic utility in the treatment of cancer. Eag and HERG are expressed in cancers of various organs and have been implicated in cell cycle progression and proliferation of cancer cells. Inhibition of these channels has been shown to reduce proliferation both in vitro and vivo studies identifying potassium channel modulators as putative inhibitors of tumour progression. Eag channels in view of their restricted expression in normal tissue may emerge as novel tumour biomarkers

Warehouse commodity classification from fundamental principles. Part II: Flame heights and flame spread

In warehouse storage applications, it is important to classify the burning behavior of commodities and rank them according to their material flammability for early fire detection and suppression operations. In this study, a preliminary approach towards commodity classification is presented that models the early stage of large-scale warehouse fires by decoupling the problem into separate processes of heat and mass transfer. Two existing nondimensional parameters are used to represent the physical phenomena at the large-scale: a mass transfer number that directly incorporates the material properties of a fuel, and the soot yield of the fuel that controls the radiation observed in the large-scale. To facilitate modeling, a mass transfer number (or B-number) was experimentally obtained using mass-loss (burning rate) measurements from bench-scale tests, following from a procedure that was developed in Part I of this paper. Two fuels are considered: corrugated cardboard and polystyrene. Corrugated cardboard provides a source of flaming combustion in a warehouse and is usually the first item to ignite and sustain flame spread. Polystyrene is typically used as the most hazardous product in large-scale fire testing. The nondimensional mass transfer number was then used to model in-rack flame heights on 6.19.1 m (2030 ft) stacks of 'C' flute corrugated cardboard boxes on rack-storage during the initial period of flame spread (involving flame spread over the corrugated cardboard face only). Good agreement was observed between the model and large-scale experiments during the initial stages of fire growth, and a comparison to previous correlations for in-rack flame heights is included. © 2011 Elsevier Ltd. All rights reserved