57 research outputs found

    Taming troubled teens: The social production of mental morbidity amongst young mothers in Pelotas, Brazil

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    Copyright @ 2011 Elsevier Ltd. This is a post-print version of the article. The published version of the article can be viewed at the link below.Explanations for the association between teen-childbearing and subsequent mental morbidity vary considerably, from those based on neurological theories of development to those investigating underlying social and economic determinants. Based on longitudinal epidemiological and ethnographic sub-studies of the 1982 Pelotas birth cohort study, this paper explores the hypothesis that teen childbearing and subsequent mental morbidity have become associated through the interplay of culture, society, and biology in situations where teen pregnancy has become a stigmatised object of scientific and public health attention. Results show that the effect of teen childbearing on subsequent mental morbidity remained significant in the multivariate analysis. Ethnographic analysis, together with epidemiological effect modification analyses, suggest that this association is partially accounted for by the fact that it is more pronounced amongst a specific subgroup of women of low socio-economic status who, being more politicised about societal injustice, were also more critically engaged with – and thus troubled by – the inequitable institutionalisation of life-cycle transitions. With time, these women became highly critical of the institutionalised identification of early childbearing as a key violation of life-cycle norms and the differential class-based application of scientific knowledge on its causes and consequences. Public health campaigns should consider how the age-based institutionalisation of developmental norms has enabled the stigmatisation of those identified as transgressors.The 1982 cohort study has been funded by The Wellcome Trust, the World Health Organisation, the PanAmerican Health Organisation, the European Union, the Programa Nacional para Centros de ExcelĂȘncia (PRONEX), the Conselho Nacional de Desenvolvimento CientĂ­fico e TecnolĂłgico (CNPq), the Brazilian Ministry of Health, and the Fundação de Amparo Ă  Pesquisa do Rio Grande do Sul (Fapergs). D BĂ©hague received support from a US National Science Foundation Doctoral Fellowship and a Postdoctoral Training Fellowship from The Wellcome Trust (Grant no. GR077175MA)

    Statistical strategies for avoiding false discoveries in metabolomics and related experiments

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    Exposure to heavy metals and infectious disease mortality in harbour porpoises from England and Wales

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    We investigate whether long-term exposure to heavy metals, including immunosuppressive metals like mercury (Hg), is associated with infections disease in a wild cetacean. Post-mortem investigations on 86 harbour porpoises, Phocoena phocoena, found dead along the coasts of England and Wales revealed that 49 of the porpoises were healthy when they died as a consequence of physical trauma (most frequently entrapment in fishing gear). In contrast, 37 porpoises died of infectious diseases caused by parasitic, bacterial, fungal and viral pathogens (most frequently pneumonia caused by lungworm and bacterial infections). We found that mean liver concentrations of Hg, selenium (Se), the Hg:Se molar ratio, and zinc (Zn) were significantly higher in the porpoises that died of infections disease compared to healthy porpoises that died from physical trauma. Liver concentrations of lead (Pb), cadmium (Cd), copper (Cu) and chromium (Cr) did not differ between the two groups. Hg, Se, and the Hg:Se molar ratio were also positively correlated with age. The association between Zn concentration and disease status may result from Zn redistribution in response to infection. Further work is required to evaluate whether chronic exposure to Hg may have presented a toxic challenge to the porpoises that succumbed to infections disease. (C) 2001 Elsevier Science Ltd. All rights reserved
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