Optimization of machine allocation in RingLeader

Many different types of distributed batch scheduling systems have been developed in the last decade to take advantage of the decentralization of computers and the enormous investments that many companies and educational institutions have in desktop workstations. Based on the premise that the majority of desktop workstations are significantly underutilized, distributed batch systems allow users to submit and run jobs when these workstations are available. While simpler systems determine machine availability by time of day (e.g., 5:00 p.m. to 8:00 a.m.), more sophisticated systems determine availability dynamically, migrating tasks when the availability changes. Ring Leader is a distributed batch system currently under development at Hewlett Packard. Since meeting the objectives of a distributed system rely on the intelligent use of idle workstations, good resource determination and efficient utilization decisions are a high priority for such a system. System performance will depend heavily on the process of deciding where jobs should be run. This thesis explains the development of Ring Leader's history based resource utilization scheme, and compares its performance to more simplistic algorithms

Chandra Observations of the Dwarf Nova WX Hyi in Quiescence

We report Chandra observations of the dwarf nova WX Hyi in quiescence. The X-ray spectrum displays strong and narrow emission lines of N, O, Mg, Ne, Si, S and Fe. The various ionization states implied by the lines suggest that the emission is produced within a flow spanning a wide temperature range, from T ~ 10^6 K to T >~ 10^8 K. Line diagnostics indicate that most of the radiation originates from a very dense region, with n ~ 10^{13}-10^{14} cm^{-3}. The Chandra data allow the first tests of specific models proposed in the literature for the X-ray emission in quiescent dwarf novae. We have computed the spectra for a set of models ranging from hot boundary layers, to hot settling flows solutions, to X-ray emitting coronae. WX Hyi differs from other dwarf novae observed at minimum in having much stronger low temperature lines, which prove difficult to fit with existing models, and possibly a very strong, broad O VII line, perhaps produced in a wind moving at a few x 10^3 km/s. The accretion rate inferred from the X-rays is lower than the value inferred from the UV. The presence of high-velocity mass ejection could account for this discrepancy while at the same time explaining the presence of the broad O VII line. If this interpretation is correct, it would provide the first detection of a wind from a dwarf nova in quiescence.Comment: accepted to ApJ; 19 pages, 3 figures, 1 tabl

A comparison of pneumolysin activity and concentration in vitro and in vivo in a rabbit endophthalmitis model

The purpose of this study was to determine whether the in vitro activity and concentration of Streptococcus pneumoniae pneumolysin correlated to the pathogenesis of S. pneumoniae endophthalmitis. Five S. pneumoniae clinical endophthalmitis strains were grown in media to similar optical densities (OD), and extracellular milieu was tested for pneumolysin activity by hemolysis of rabbit red blood cells. Pneumolysin concentration was determined using a sandwich ELISA. Rabbit vitreous was injected with 102 colony-forming units (CFU) of 1 of 2 different strains with low hemolytic activity (n = 10 and 12 for strains 4 and 5, respectively) or 1 of 3 different strains with high hemolytic activity (n = 12 per strain). Pathogenesis of endophthalmitis infection was graded by slit lamp examination (SLE) at 24 hours post-infection. Bacteria were recovered from infected vitreous and quantitated. The SLE scores of eyes infected with strains having high hemolytic activity were significantly higher than the scores of those infected with strains having low hemolytic activity (P < 0.05). Pneumolysin concentration in vitro, however, did not correlate with hemolysis or severity of endophthalmitis. Bacterial concentrations from the vitreous infected with 4 of the strains were not significantly different (P > 0.05). These data suggest that pneumolysin hemolytic activity in vitro directly correlates to the pathogenesis of S. pneumoniae endophthalmitis. The protein concentration of pneumolysin, however, is not a reliable indicator of pneumolysin activity

Functional liquid structures by emulsification of graphene and other two-dimensional nanomaterials

Pickering emulsions stabilised with nanomaterials provide routes to a range of functional macroscopic assemblies. We demonstrate the formation and properties of water-in-oil emulsions prepared through liquid-phase exfoliation of graphene. Due to the functional nature of the stabiliser, the emulsions exhibit conductivity due to inter-particle tunnelling. We demonstrate a strain sensing application with a large gauge factor of ~40; the highest reported in a liquid. Our methodology can be applied to other two-dimensional layered materials opening up applications such as energy storage materials, and flexible and printable electronics

Ultrasensitive strain gauges enabled by graphene-stabilized silicone emulsions

Here, an approach is presented to incorporate graphene nanosheets into a silicone rubber matrix via solid stabilization of oil‐in‐water emulsions. These emulsions can be cured into discrete, graphene‐coated silicone balls or continuous, elastomeric films by controlling the degree of coalescence. The electromechanical properties of the resulting composites as a function of interdiffusion time and graphene loading level are characterized. With conductivities approaching 1 S m−1, elongation to break up to 160%, and a gauge factor of ≈20 in the low‐strain linear regime, small strains such as pulse can be accurately measured. At higher strains, the electromechanical response exhibits a robust exponential dependence, allowing accurate readout for higher strain movements such as chest motion and joint bending. The exponential gauge factor is found to be ≈20, independent of loading level and valid up to 80% strain; this consistent performance is due to the emulsion‐templated microstructure of the composites. The robust behavior may facilitate high‐strain sensing in the nonlinear regime using nanocomposites, where relative resistance change values in excess of 107 enable highly accurate bodily motion monitoring

Raman cooling and heating of two trapped Ba+ ions

We study cooling of the collective vibrational motion of two 138Ba+ ions confined in an electrodynamic trap and irradiated with laser light close to the resonances S_1/2-P_1/2 (493 nm) and P_1/2-D_3/2 (650 nm). The motional state of the ions is monitored by a spatially resolving photo multiplier. Depending on detuning and intensity of the cooling lasers, macroscopically different motional states corresponding to different ion temperatures are observed. We also derive the ions' temperature from detailed analytical calculations of laser cooling taking into account the Zeeman structure of the energy levels involved. The observed motional states perfectly match the calculated temperatures. Significant heating is observed in the vicinity of the dark resonances of the Zeeman-split S_1/2-D_3/2 Raman transitions. Here two-photon processes dominate the interaction between lasers and ions. Parameter regimes of laser light are identified that imply most efficient laser cooling.Comment: 8 pages, 5 figure

Maternal Diabetes and Obesity Influence the Fetal Epigenome in a Largely Hispanic Population

BACKGROUND: Obesity and diabetes mellitus are directly implicated in many adverse health consequences in adults as well as in the offspring of obese and diabetic mothers. Hispanic Americans are particularly at risk for obesity, diabetes, and end-stage renal disease. Maternal obesity and/or diabetes through prenatal programming may alter the fetal epigenome increasing the risk of metabolic disease in their offspring. The aims of this study were to determine if maternal obesity or diabetes mellitus during pregnancy results in a change in infant methylation of CpG islands adjacent to targeted genes specific for obesity or diabetes disease pathways in a largely Hispanic population. METHODS: Methylation levels in the cord blood of 69 newborns were determined using the Illumina Infinium MethylationEPIC BeadChip. Over 850,000 different probe sites were analyzed to determine whether maternal obesity and/or diabetes mellitus directly attributed to differential methylation; epigenome-wide and regional analyses were performed for significant CpG sites. RESULTS: Following quality control, agranular leukocyte samples from 69 newborns (23 normal term (NT), 14 diabetes (DM), 23 obese (OB), 9 DM/OB) were analyzed for over 850,000 different probe sites. Contrasts between the NT, DM, OB, and DM/OB were considered. After correction for multiple testing, 15 CpGs showed differential methylation from the NT, associated with 10 differentially methylated genes between the diabetic and non-diabetic subgroups, CCDC110, KALRN, PAG1, GNRH1, SLC2A9, CSRP2BP, HIVEP1, RALGDS, DHX37, and SCNN1D. The effects of diabetes were partly mediated by the altered methylation of HOOK2, LCE3C, and TMEM63B. The effects of obesity were partly mediated by the differential methylation of LTF and DUSP22. CONCLUSIONS: The presented data highlights the associated altered methylation patterns potentially mediated by maternal diabetes and/or obesity. Larger studies are warranted to investigate the role of both the identified differentially methylated loci and the effects on newborn body composition and future health risk factors for metabolic disease. Additional future consideration should be targeted to the role of Hispanic inheritance. Potential future targeting of transgenerational propagation and developmental programming may reduce population obesity and diabetes risk

Light-shift-induced quantum gates for ions in thermal motion

An effective interaction between trapped ions in thermal motion can be generated by illuminating them simultaneously with a single laser resonant with the ionic carrier frequency. The ac Stark-shift induces simultaneous `virtual' two-phonon transitions via several motional modes. Within a certain laser intensity range these transitions can interfere constructively, resulting in a relatively fast, heating-resistant two-qubit logic gate