Characterization of greater middle eastern genetic variation for enhanced disease gene discovery

The Greater Middle East (GME) has been a central hub of human migration and population admixture. The tradition of consanguinity, variably practiced in the Persian Gulf region, North Africa, and Central Asia1-3, has resulted in an elevated burden of recessive disease4. Here we generated a whole-exome GME variome from 1,111 unrelated subjects. We detected substantial diversity and admixture in continental and subregional populations, corresponding to several ancient founder populations with little evidence of bottlenecks. Measured consanguinity rates were an order of magnitude above those in other sampled populations, and the GME population exhibited an increased burden of runs of homozygosity (ROHs) but showed no evidence for reduced burden of deleterious variation due to classically theorized ‘genetic purging’. Applying this database to unsolved recessive conditions in the GME population reduced the number of potential disease-causing variants by four- to sevenfold. These results show variegated genetic architecture in GME populations and support future human genetic discoveries in Mendelian and population genetics

A Novel Approach for Organic Strawberry Cultivation: Vermicompost-Based Fertilization and Microbial Complementary Nutrition

This study investigated the effects of vermicompost fertilization with complementary microbial nutrition on the plant growth, yield, and fruit quality of the organically grown strawberry “Monterey” cultivar. Along with vermicompost, five different microbial fertilizers containing plant-growth-promoting rhizobacteria (PGPR) and arbuscular mycorrhizal fungi (AMF) were used as complementary nutrition. Here, we examined plant growth parameters, strawberry yield, fruit weight, pH, total soluble solids, and acidity in fruit and leaf mineral nutrient concentrations. Vermicompost-based fertilization with PGPR and AMF improved plant growth, yield, and fruit quality. The highest total yield (216.75 g per plant−1) and heaviest fruits with an average of 18.11 g were obtained from the vermicompost-based fertilization with PGPR containing complementary fertilization. This included Bacillus amyloliquefaciens, Bacillus pumilus, Bacillus subtilis, Bacillus licheniformis, Bacillus megaterium, Trichoderma harzianum, and Trichoderma konigii. This treatment also resulted in the best ratio of total soluble solids to acidity (18.74), pH (3.95), and mineral nutrient concentrations in leaves. The novel approach with vermicompost-based fertilization and complementary microbial nutrition improves organic strawberries’ growth, yield, and fruit quality. These results are promising for enhancing organic strawberry production

Morphologic and seismic evidence of rapid submergence offshore Cide-Sinop in the southern Black Sea shelf

Multi-beam bathymetric and multi-channel seismic reflection data obtained offshore Cide-Sinop have revealed important records on the latest transgression of the Black Sea for the first time. A relatively large shelf plain within the narrow southern continental shelf characterized by a flat seafloor morphology at -100 water depth followed by a steep continental slope leading to -500 m depth. This area is widely covered by submerged morphological features such as dunes, lagoons, possible aeolianites, an eroded anticline and small channels that developed by aeolian and fluvial processes. These morphological features sit upon an erosional surface that truncates the top of all seismic units and constitutes the seafloor over the whole shelf. The recent prograded delta deposits around the shelf break are also truncated by the similar erosional surface. These results indicate that offshore Cide-Sinop was once a terrestrial landscape that was then submerged. The interpreted paleoshoreline varies from -100 to -120 m. This variation can be explained by not only sea level changes but also the active faults observed on the seismic section. The effective protection of morphological features on the seafloor is the evidence of abrupt submergence rather than gradual. In addition, the absence of coastal onlaps suggests that these morphological features should have developed at low sea level before the latest sea level rise in the Black Sea. (C) 2018 Elsevier B.V. All rights reserved

Europium dependent absorption properties of Zn1-(y+0.01)(Al-0.01,Eu (y) )O (y=0.00, 0.01, 0.03 and 0.05) thin films grown on the soda-lime glass substrates by spin coating

We measured the absorption/transmission performance of ZnO thin films doped with europium (Eu) and aluminum (Al). ZnO and Zn1-(y+0.01)(Al-0.01, Eu-y)O (y = 0.00, 0.01, 0.03 and 0.05) nano particles were synthesized using sol-gel method and covered on a soda-lime glass surface by spin coating. After annealing at 500 A degrees C, UV-Vis. measurements were performed in wavelength range of 300 and 800 nm to calculate the band gap of nano particles from the absorption/transmission performances. The resistivity measurements were employed to understand the relationship between band gap and DC electrical performance by Eu amount of each Zn1-(y+0.01)(Al-0.01, Eu (y) )O thin film. As a conclusion, after reaching a minimum value with 1 mol% Eu doping, a monotonic increase in band gap was observed by enhancing Eu amounts in Zn0.99Al0.01O lattice

The Effect of Changes in Coastal Law on Land Use Change in Coastal Settlements: Kusadasi Center Case

Coasts have always been attractive areas within the scope of the possibilities for use for the society; The natural resources on the coast have played an important role in the economic and social development of the coastal regions and the country. In the coastal areas of Turkey, country rich in this important area of protection and legislation relating to planning; it was not sufficient to determine the right land use decisions, to introduce regulations that increase the quality of life of the society and to ensure sustainable development. This study, which is planned to be one of the leading coastal settlements on the shores of the issue of Turkey Aydin Province Kuadasi District has addressed over the coast. Land use changes and planning processes in Kuadasi coasts have been investigated and evaluated comparatively and coastal use has been analyzed within periods. spatial analysis results for Kuadasi coast evaluated within the framework of the process of change in Turkey and has introduced legislation for coastal planning issues. It is understood that non-public practices, illegal and irregular constructions have occurred on the coasts of Kuadasi and many natural areas have been damaged. The main sources of these problems are; It is understood that there is a lack of definitive provisions regarding the public use of the coasts in the relevant legislation, especially tourism-oriented privileged legislation, lack of control, lack of holistic planning and management

The Prevalances and Patient Characteristics of Primary Immunodeficiency Diseases in Turkey-Two Centers Study

WOS: 000323117100010PubMed ID: 22983506Purpose Primary immunodeficiency diseases (PIDs) are inherited disorders of the immune system resulting in increased susceptibility to unusual infections and predisposition to autoimmunity and malignancies. The European Society for Immunodeficiencies (ESID) has developed an internet-based database for clinical and research data on patients with PID. This study aimed to provide a minimum estimate of the prevalence of each disorder and to determine the clinical characteristics and outcomes of patients with PID in Turkey. Methods Clinical features of 1435 patients with primary immunodeficiency disorders are registered in ESID Online Patient Registry by the Pediatric Immunology Departments of the Medical Faculties of Uludag University and Ege University Between 2004 and 2010. These two centers are the major contributors reporting PID patients to ESID database from Turkey. Results Predominantly antibody immunodeficiency (73.9 %) was the most common category followed by autoinflammatory disorders (13.3 %), other well defined immunodeficiencies (5.5 %), congenital defects of phagocyte number, function or both (3.5 %), combined T and B cell immunodeficiencies (2 %), defects in innate immunity (1 %), and diseases of immune dysregulation (0.7 %) and complement deficiencies (0.4 %). Patients between 0 and 18 years of age constitued 94 % of total and the mean age was 9.2 +/- 6 years. The consanguinity rate within the registered patients was 14.3 % (188 of 1130 patients). The prevalance of all PID cases ascertained from the registry was 30.5/100.000. The major cause of the mortality was severe infection which was seen in forty-two of seventy five deceased patients. The highest mortality was observed in patients with severe combined immunodeficiencies and ataxia-telangiectasia. Conclusion Promoting the awareness of PID among the medical professionals and the general public is required if premature death and serious morbidity occurs due to late diagnosis of the wider spectrum of PID are to be avoided

Caveolin 1 Gene Variants May Effect Disease Progression in Systemic Sclerosis Related Interstitial Lung Disease

WOS: 000370860203282