Тенденции развития комплексных транспортных схем городов

The article discusses the process of planning the work of urban transport operations in the form of an integrated transport scheme (ITS), which is the transport part of the master plan for development of a city, and studies organization of urban transport. The objective of the article is to formulate the main directions of developments in the field of transport planning based on modern domestic and foreign experience and knowledge, and on retrospective analysis of changes in the field of urban transport planning.The methodology is presented for the conditions prevailing in the Russian Federation, the peculiarity of which comprise a relatively late (compared to European countries and the USA), but rapidly developing motorization of the country, a change in qualifications of specialists working in the field of urban transport planning, a certain loss of experience and skills in development of ITS in recent years.The suggested conclusions represent a brief description of the concept of a common toolkit, a scheme and the most promising methods for developing approaches to development of integrated transport schemes and require further in-depth research in each specific segment.В статье рассматривается процесс планирования работы городского транспорта в форме комплексной транспортной схемы (КТС), являющейся транспортной частью генерального плана развития города и рассматривающей вопросы организации городского транспорта. Цель статьи – сформулировать основные направления разработок в сфере транспортного планирования на основе современного отечественного и зарубежного опыта и знаний, в том числе с использованием ретроспективного анализа изменений в сфере планирования городского транспорта.Анализ представлен для условий Российской Федерации, особенностями которых являются относительно поздняя (по сравнению со странами Европы и США), но быстро протекающая автомобилизация страны, изменение квалификационного состава специалистов, работающих в сфере планирования городского транспорта, определённая потеря опыта и умения разработки КТС за последние годы.Предложенные выводы представляют собой краткое описание концепта общего инструментария, схем и наиболее перспективных методов разработки подходов к развитию комплексных транспортных схем и требуют дальнейших углублённых исследований по каждому направлению

Tuning the non-covalent confinement of Gd(III) complexes in silica nanoparticles for high T<inf>1</inf>-weighted MR imaging capability

© 2016 Elsevier B.V.The present work introduces deliberate synthesis of Gd(III)-doped silica nanoparticles with high relaxivity at magnetic field strengths below 1.5 T. Modified microemulsion water-in-oil procedure was used in order to achieve superficial localization of Gd(III) complexes within 40–55 nm sized silica spheres. The relaxivities of the prepared nanoparticles were measured at 0.47, 1.41 and 1.5 T with the use of both NMR analyzer and whole body NMR scanner. Longitudinal relaxivities of the obtained silica nanoparticles reveal significant dependence on the confinement mode, changing from 4.1 to 49.6 mM−1 s−1 at 0.47 T when the localization of Gd(III) complexes changes from core to superficial zones of the silica spheres. The results highlight predominant contribution of the complexes located close to silica/water interface to the relaxivity of the nanoparticles. Low effect of blood proteins on the relaxivity in the aqueous colloids of the nanoparticles was exemplified by serum bovine albumin. T1- weighted MRI data indicate that the nanoparticles provide strong positive contrast at 1.5 T, which along with low cytotoxicity effect make a good basis for their application as contrast agents

Полиморфная нейроэпиталиальная опухоль низкой степени злокачественности молодого возраста (PLNTY), новые радиологические особенности: клинический случай

A new form of morphologically and molecularly distinguishable epileptogenic neoplasia with characteristic microscopic findings and a distinct DNA methylation signature as well as frequent genetic anomalies, was revealed in 2017; the tumor was called polymorphous low-grade neuroepithelial tumor of the young (PLNTY). Several specific radiological patterns found in PLNTY when compared with the results of a pathomorphological study being useful in differential diagnosis with other epileptogenic tumors were mentioned in certain papers. Our paper is devoted to some particulars of the radiological picture in two children with pharmacoresistant epilepsy who underwent epileptic surgery with histological verification of PLNTY.В 2017 г. обнаружена новая форма морфологически и молекулярно различимой эпилептогенной неоплазии, имеющая характерные микроскопические находки и отчетливую сигнатуру метилирования ДНК, наряду с частыми генетическими аномалиями, получившая название полиморфная нейроэпителиальная опухоль низкой степени злокачественности молодого возраста (PLNTY). В литературе упоминается о нескольких специфических радиологических паттернах, встречающихся у PLNTY, которые при сопоставлении с результатами патоморфологического исследования могут быть полезны при дифференциальной диагностике с другими эпилептогенными опухолями. Мы сообщаем о некоторых особенностях радиологической картины у двух детей с фармакорезистентной эпилепсией, прошедших процедуру эпилептической хирургии с гистологической верификацией PLNTY.

Spectroelectrochemistry: ESR of Paramagnetic Intermediates in the Electron Transfer Series [Cr(bpy)<inf>3</inf>]ⁿ (n = 3+, 2+, 1+, 0, 1-)

© 2015 Elsevier Ltd. All rights reserved. A new method of cyclic voltammetry with simultaneous ESR spectra multiple recording (CV-MRESR) has been proposed and implemented. Along with cyclic voltammetry (CV) and electron spin resonance (ESR), the combined method involving cyclic voltammetry and ESR (CV-ESR) has been used for the study of electron transfer in a series of complexes [Cr(bpy)3]n (n = 3+, 2+, 1+, 0, 1-)

Tuning the non-covalent confinement of Gd(III) complexes in silica nanoparticles for high T<inf>1</inf>-weighted MR imaging capability

© 2016 Elsevier B.V.The present work introduces deliberate synthesis of Gd(III)-doped silica nanoparticles with high relaxivity at magnetic field strengths below 1.5 T. Modified microemulsion water-in-oil procedure was used in order to achieve superficial localization of Gd(III) complexes within 40–55 nm sized silica spheres. The relaxivities of the prepared nanoparticles were measured at 0.47, 1.41 and 1.5 T with the use of both NMR analyzer and whole body NMR scanner. Longitudinal relaxivities of the obtained silica nanoparticles reveal significant dependence on the confinement mode, changing from 4.1 to 49.6 mM−1 s−1 at 0.47 T when the localization of Gd(III) complexes changes from core to superficial zones of the silica spheres. The results highlight predominant contribution of the complexes located close to silica/water interface to the relaxivity of the nanoparticles. Low effect of blood proteins on the relaxivity in the aqueous colloids of the nanoparticles was exemplified by serum bovine albumin. T1- weighted MRI data indicate that the nanoparticles provide strong positive contrast at 1.5 T, which along with low cytotoxicity effect make a good basis for their application as contrast agents

One-pot embedding of iron oxides and Gd(III) complexes into silica nanoparticles—Morphology and aggregation effects on MRI dual contrasting ability

© 2018 Elsevier B.V. The present work introduces one-pot synthetic route to join ultra-small iron oxides (6 nm) with Gd(III) complexes in small (∼30 nm) silica nanoparticles with high longitudinal and transverse relaxivity values (r1 = 34.7 mM−1 s−1 and r2 = 64.7 mM−1 s−1 at 0.47 T). The design of the nanoparticles is based on the core-shell morphology, where the Gd(III) complexes were doped into the exterior silica layer. The doping mode is the reason for an efficient interfacial hydration and the small suppressing of r1 by iron oxides. The measurements on the whole body scanner at 1.5 T confirm the high contrasting abilities of T1 (Gd) and T2 (iron oxide) components in the nanoparticles. Poor aggregation behavior of the nanoparticles in water is due to high electrokinetic potential value (−78 mV). Greater aggregation of the nanoparticles in the buffer solutions of bovine serum albumin enhances the disturbing effect of iron oxides on the longitudinal relaxation and facilitates the transverse relaxation. The higher surface activity of the nanoparticles results in their greater cytotoxicity versus the silica coated iron oxides, although the cytotoxicity is low in the concentration range which is within the region of interest for MRI technique

A Ni(III) complex stabilized by silica nanoparticles as an efficient nanoheterogeneous catalyst for oxidative C-H fluoroalkylation

© The Royal Society of Chemistry 2016.We have developed NiIII-doped silica nanoparticles ([(bpy)xNiIII]@SiO2) as a recyclable, low-leaching, and efficient oxidative functionalization nanocatalyst for aromatic C-H bonds. The catalyst is obtained by doping the complex [(bpy)3NiII] on silica nanoparticles along with its subsequent electrooxidation to [(bpy)xNiIII] without an additional oxidant. The coupling reaction of arenes with perfluoroheptanoic acid occurs with 100% conversion of reactants in a single step at room temperature under nanoheterogeneous conditions. The catalyst content is only 1% with respect to the substrates under electrochemical regeneration conditions. The catalyst can be easily separated from the reaction mixture and reused a minimum of five times. The results emphasize immobilization on the silica support and the electrochemical regeneration of NiIII complexes as a facile route for developing an efficient nanocatalyst for oxidative functionalization

Cellular imaging by green luminescence of Tb(III)-doped aminomodified silica nanoparticles

© 2017 Elsevier B.V.The work introduces Tb(III)-centered luminescence of amino-modified silica nanoparticles doped with Tb(III) complexes for cellular imaging. For these purposes water-in-oil procedure was optimized for synthesis of 20 and 35 nm luminescent nanoparticles with amino-groups embedded on the surface. The obtained results indicate an impact of the nanoparticle size in decoration, aggregation behavior and luminescent properties of the nanoparticles in protein-based buffer solutions. Formation of a protein-based corona on the nanoparticles surface was revealed through the effect of the nanoparticles on helical superstructure of BSA. This effect is evident from CD spectral data, while no any size impact on the adsorption of BSA onto aminomodified silica surface was observed. Cellular uptake of the nanoparticles studied by confocal and TEM microscopy methods indicates greater cellular uptake for the smaller nanoparticles. Cytotoxicity of the nanoparticles was found to agree well with their cellular uptake behavior, which in turn was found to be greater for the smaller nanoparticles

Epizootiological and Epidemiological Situation on Tularemia in Russia in 2020, the Forecast for 2021

The purpose of the review is to assess the trends in the development of epizootic activity in various territories of the Russian Federation in order to identify the regions of increased risk of infection of the population with tularemia pathogen in 2021 and to plan and carry out high-priority measures in these regions, such as vaccination, investments in water, sanitation and hygiene infrastructure, epizootiological monitoring of natural foci and other measures aimed at suppressing the activity of natural foci and the development of herd immunity to this infection. In 2020, 41 cases of human infection with tularemia pathogen were registered on the territory of the Russian Federation, 60 % of which occurred in the Northwestern Federal District. Epizootic manifestations of the infection of varying intensity were detected in 55 constituent entities of Russia. Against this background, sporadic cases of tularemia in humans were registered in 14 regions of the country. The most pronounced epidemic complications continue in the territory of Karelia – 23 patients. 12 cultures of Francisella tularensis subsp. holarctica from the ambient environment were isolated in the Vologda (3), Rostov Regions (6), in the Khanty-Mansi Autonomous District (2), and in St. Petersburg (1). Based on the analysis of the data presented, in 2021, epidemic complications in the form of sporadic cases of the disease among the unvaccinated population in the following territories are most likely to occur: Central Federal District – in the Oryol, Ryazan and Yaroslavl Regions, as well as in Moscow; Northwestern Federal District – in the Arkhangelsk and Leningrad Regions, the Republic of Karelia and in St. Petersburg; Volga Federal District – in Tatarstan, Mordovia, Chuvash Republic, Kirov and Orenburg Regions; Ural Federal District – in the Khanty-Mansiysk, Yamalo-Nenets Autonomous Districts and the Tyumen Region; Siberian Federal District – in the Novosibirsk, Kemerovo, Tomsk and Omsk Regions, as well as in the Altai Territory; Far Eastern Federal District – in some regions of Kamchatka and Khabarovsk Territories