CORE
🇺🇦
make metadata, not war
Services
Services overview
Explore all CORE services
Access to raw data
API
Dataset
FastSync
Content discovery
Recommender
Discovery
OAI identifiers
OAI Resolver
Managing content
Dashboard
Bespoke contracts
Consultancy services
Support us
Support us
Membership
Sponsorship
Community governance
Advisory Board
Board of supporters
Research network
About
About us
Our mission
Team
Blog
FAQs
Contact us
Tuning the non-covalent confinement of Gd(III) complexes in silica nanoparticles for high T<inf>1</inf>-weighted MR imaging capability
Authors
Amirov R.
Fattakhova A.
+10 more
Fedorenko S.
Grechkina S.
Ismaev I.
Kadirov M.
Kholin K.
Mustafina A.
Nizameev I.
Soloveva S.
Stepanov A.
Zairov R.
Publication date
1 January 2017
Publisher
Abstract
© 2016 Elsevier B.V.The present work introduces deliberate synthesis of Gd(III)-doped silica nanoparticles with high relaxivity at magnetic field strengths below 1.5 T. Modified microemulsion water-in-oil procedure was used in order to achieve superficial localization of Gd(III) complexes within 40–55 nm sized silica spheres. The relaxivities of the prepared nanoparticles were measured at 0.47, 1.41 and 1.5 T with the use of both NMR analyzer and whole body NMR scanner. Longitudinal relaxivities of the obtained silica nanoparticles reveal significant dependence on the confinement mode, changing from 4.1 to 49.6 mM−1 s−1 at 0.47 T when the localization of Gd(III) complexes changes from core to superficial zones of the silica spheres. The results highlight predominant contribution of the complexes located close to silica/water interface to the relaxivity of the nanoparticles. Low effect of blood proteins on the relaxivity in the aqueous colloids of the nanoparticles was exemplified by serum bovine albumin. T1- weighted MRI data indicate that the nanoparticles provide strong positive contrast at 1.5 T, which along with low cytotoxicity effect make a good basis for their application as contrast agents
Similar works
Full text
Open in the Core reader
Download PDF
Available Versions
Kazan Federal University Digital Repository
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:dspace.kpfu.ru:net/143113
Last time updated on 07/05/2019