Combustion pattern, characteristics, and kinetics of biomass and chars from segmented heating carbonization

The combustion patterns, characteristics, and kinetics were investigated by thermogravimetric analysis for raw maize straw, cotton stalk, and chars obtained from segmented heating carbonization at 300–800 °C. With increasing carbonization temperature, combustion patterns of biomass chars transform from the sequential reaction steps corresponding to pyrolysis and heterogeneous oxidation of volatiles and char to the in situ heterogeneous oxidation of fixed carbon and volatiles, the ignition temperature of biomass chars gradually increases, the ignition index does not monotonically increase, and the burnout index and combustion characteristic index decrease to different degrees. Judging from the combustion characteristic index, chars obtained from 300 to 500 °C of carbonization show better combustibility. The kinetic parameters of raw and carbonized biomass were determined by Coats–Redfern method. Different reaction mechanisms exist in oxidation processes of different chars, which attribute to the synergistic effects of homogenous oxidation of volatiles and heterogeneous oxidation of char. The kinetic parameters obtained from the variation of species and model functions exhibit kinetic compensation effect

Random Matrix Theory of the Energy-Level Statistics of Disordered Systems at the Anderson Transition

We consider a family of random matrix ensembles (RME) invariant under similarity transformations and described by the probability density $P({\bf H})= \exp[-{\rm Tr}V({\bf H})]$. Dyson's mean field theory (MFT) of the corresponding plasma model of eigenvalues is generalized to the case of weak confining potential, $V(\epsilon)\sim {A\over 2}\ln ^2(\epsilon)$. The eigenvalue statistics derived from MFT are shown to deviate substantially from the classical Wigner-Dyson statistics when $A<1$. By performing systematic Monte Carlo simulations on the plasma model, we compute all the relevant statistical properties of the RME with weak confinement. For $A_c\approx 0.4$ the distribution function of the energy-level spacings (LSDF) of this RME coincides in a large energy window with the LSDF of the three dimensional Anderson model at the metal-insulator transition. For the same $A_c$, the variance of the number of levels, $\langle n^2\rangle -\langle n\rangle^2$, in an interval containing $\langle n\rangle$ levels on average, grows linearly with $\langle n\rangle$, and its slope is equal to $0.32 \pm 0.02$, which is consistent with the value found for the Anderson model at the critical point.Comment: 32 pages, REVTEX 3.0, 10 postscript (uuencoded) figures include

Association of subclinical myocardial injury with arterial stiffness in patients with type 2 diabetes mellitus

published_or_final_versio

Crystal structure of the N‐terminal region of human Ash2L shows a winged‐helix motif involved in DNA binding

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/102216/1/embr2011101-sup-0001.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/102216/2/embr2011101.reviewer_comments.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/102216/3/embr2011101.pd

The role of mutation rate variation and genetic diversity in the architecture of human disease

Background We have investigated the role that the mutation rate and the structure of genetic variation at a locus play in determining whether a gene is involved in disease. We predict that the mutation rate and its genetic diversity should be higher in genes associated with disease, unless all genes that could cause disease have already been identified. Results Consistent with our predictions we find that genes associated with Mendelian and complex disease are substantially longer than non-disease genes. However, we find that both Mendelian and complex disease genes are found in regions of the genome with relatively low mutation rates, as inferred from intron divergence between humans and chimpanzees, and they are predicted to have similar rates of non-synonymous mutation as other genes. Finally, we find that disease genes are in regions of significantly elevated genetic diversity, even when variation in the rate of mutation is controlled for. The effect is small nevertheless. Conclusions Our results suggest that gene length contributes to whether a gene is associated with disease. However, the mutation rate and the genetic architecture of the locus appear to play only a minor role in determining whether a gene is associated with disease

Biological and technical variables affecting immunoassay recovery of cytokines from human serum and simulated vaginal fluid: A multicenter study

The increase of proinflammatory cytokines in vaginal secretions may serve as a surrogate marker of unwanted inflammatory reaction to microbicide products topically applied for the prevention of sexually transmitted diseases, including HIV-1. Interleukin (IL)-1β and IL-6 have been proposed as indicators of inflammation and increased risk of HIV-1 transmission; however, the lack of information regarding detection platforms optimal for vaginal fluids and interlaboratory variation limit their use for microbicide evaluation and other clinical applications. This study examines fluid matrix variants relevant to vaginal sampling techniques and proposes a model for interlaboratory comparisons across current cytokine detection technologies. IL-1β and IL-6 standards were measured by 12 laboratories in four countries, using 14 immunoassays and four detection platforms based on absorbance, chemiluminescence, electrochemiluminescence, and fluorescence. International reference preparations of cytokines with defined biological activity were spiked into (1) a defined medium simulating the composition of human vaginal fluid at pH 4.5 and 7.2, (2) physiologic salt solutions (phosphate-buffered saline and saline) commonly used for vaginal lavage sampling in clinical studies of cytokines, and (3) human blood serum. Assays were assessed for reproducibility, linearity, accuracy, and significantly detectable fold difference in cytokine level. Factors with significant impact on cytokine recovery were determined by Kruskal−Wallis analysis of variance with Dunn’s multiple comparison test and multiple regression models. All assays showed acceptable intra-assay reproducibility; however, most were associated with significant interlaboratory variation. The smallest reliably detectable cytokine differences (P < 0.05) derived from pooled interlaboratory data varied from 1.5- to 26-fold depending on assay, cytokine, and matrix type. IL-6 but not IL-1β determinations were lower in both saline and phosphate-buffered saline as compared to vaginal fluid matrix, with no significant effect of pH. The (electro)chemiluminescence-based assays were most discriminative and consistently detected <2-fold differences within each matrix type. The Luminex-based assays were less discriminative with lower reproducibility between laboratories. These results suggest the need for uniform vaginal sampling techniques and a better understanding of immunoassay platform differences and cross-validation before the biological significance of cytokine variations can be validated in clinical trials. This investigation provides the first standardized analytic approach for assessing differences in mucosal cytokine levels and may improve strategies for monitoring immune responses at the vaginal mucosal interface

Multi-Wavelength Monitoring of the Changing-Look AGN NGC 2617 during State Changes

Optical and near-infrared photometry, optical spectroscopy, and soft X-ray and UV monitoring of the changing-look active galactic nucleus NGC 2617 show that it continues to have the appearance of a type-1 Seyfert galaxy. An optical light curve for 2010-2017 indicates that the change of type probably occurred between 2010 October and 2012 February and was not related to the brightening in 2013. In 2016 and 2017 NGC 2617 brightened again to a level of activity close to that in 2013 April. However, in 2017 from the end of the March to end of July 2017 it was in very low level and starting to change back to a Seyfert 1.8. We find variations in all passbands and in both the intensities and profiles of the broad Balmer lines. A new displaced emission peak has appeared in Hβ. X-ray variations are well correlated with UV-optical variability and possibly lead by ̃2-3 d. The K band lags the J band by about 21.5 ± 2.5 d and lags the combined B + J bands by ̃25 d. J lags B by about 3 d. This could be because J-band variability arises predominantly from the outer part of the accretion disc, while K-band variability is dominated by thermal re-emission by dust. We propose that spectral-type changes are a result of increasing central luminosity causing sublimation of the innermost dust in the hollow bi-conical outflow. We briefly discuss various other possible reasons that might explain the dramatic changes in NGC 2617.Fil: Oknyansky, V. L.. Sternberg Astronomical Institute; RusiaFil: Gaskell, C. M.. Department of Astronomy and Astrophysics. University of California. Santa Cruz; Estados UnidosFil: Mikailov, K. M.. Shamakhy Astrophysical Observatory, National Academy of Sciences. Pirkuli; AzerbaiyánFil: Lipunov, V. M.. Sternberg Astronomical Institute. M.V.Lomonosov Moscow State University ; RusiaFil: Shatsky, N. I.. Sternberg Astronomical Institute. M.V.Lomonosov Moscow State University; RusiaFil: Tsygankov, S. S.. Tuorla Observatory, Department of Physics and Astronomy. University of Turku.; FinlandiaFil: Gorbovskoy, E. S.. Sternberg Astronomical Institute. M.V.Lomonosov Moscow State University; RusiaFil: Tatarnikov, A. M.. Sternberg Astronomical Institute. M.V.Lomonosov Moscow State University; RusiaFil: Metlov, V. G.. Sternberg Astronomical Institute. M.V.Lomonosov Moscow State University; RusiaFil: Malanchev, K. L.. Sternberg Astronomical Institute. M.V.Lomonosov Moscow State University; RusiaFil: Brotherton, M.B.. University of Wyoming; Estados UnidosFil: Kasper, D.. University of Wyoming; Estados UnidosFil: Du, P.. Institute of High Energy Physics. Chinese Academy of Sciences; ChinaFil: Chen, X.. School of Space Science and Physics. Shandong University; ChinaFil: Burlak, M. A.. Sternberg Astronomical Institute. M.V.Lomonosov Moscow State University; RusiaFil: Buckley, D. A. H.. The South African Astronomical Observatory; SudáfricaFil: Rebolo, R.. Instituto de Astrofisica de Canarias; EspañaFil: Serra-Ricart, M.. Instituto de Astrofisica de Canarias; EspañaFil: Podestá, R.. Universidad Nacional de San Juan; ArgentinaFil: Levato, O. H.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan. Instituto de Ciencias Astronómicas, de la Tierra y del Espacio. Universidad Nacional de San Juan. Instituto de Ciencias Astronómicas, de la Tierra y del Espacio; Argentin

Video enhancement using adaptive spatio-temporal connective filter and piecewise mapping

This paper presents a novel video enhancement system based on an adaptive spatio-temporal connective (ASTC) noise filter and an adaptive piecewise mapping function (APMF). For ill-exposed videos or those with much noise, we first introduce a novel local image statistic to identify impulse noise pixels, and then incorporate it into the classical bilateral filter to form ASTC, aiming to reduce the mixture of the most two common types of noises - Gaussian and impulse noises in spatial and temporal directions. After noise removal, we enhance the video contrast with APMF based on the statistical information of frame segmentation results. The experiment results demonstrate that, for diverse low-quality videos corrupted by mixed noise, underexposure, overexposure, or any mixture of the above, the proposed system can automatically produce satisfactory results