2,222 research outputs found
Accuracy and sensitivity of four-dimensional dose calculation to systematic motion variability in stereotatic body radiotherapy (SBRT) for lung cancer
published_or_final_versio
Quantum field theoretic approach to neutrino oscillations in matter
We consider neutrino oscillations in non-uniform matter in a quantum field
theoretic (QFT) approach, in which neutrino production, propagation and
detection are considered as a single process. We find the conditions under
which the oscillation probability can be sensibly defined and demonstrate how
the properly normalized oscillation probability can be obtained in the QFT
framework. We derive the evolution equation for the oscillation amplitude and
discuss the conditions under which it reduces to the standard
Schr\"odinger-like evolution equation. It is shown that, contrary to the common
usage, the Schr\"odinger-like evolution equation is not applicable in certain
cases, such as oscillations of neutrinos produced in decays of free pions
provided that sterile neutrinos with eV exist.Comment: LaTeX, 24 pages + 16 pages of appendices, 1 figure. V2: typos
correcte
Mass hierarchy, 2-3 mixing and CP-phase with Huge Atmospheric Neutrino Detectors
We explore the physics potential of multi-megaton scale ice or water
Cherenkov detectors with low ( GeV) threshold. Using some proposed
characteristics of the PINGU detector setup we compute the distributions of
events versus neutrino energy and zenith angle , and study
their dependence on yet unknown neutrino parameters. The
regions are identified where the distributions have the highest sensitivity to
the neutrino mass hierarchy, to the deviation of the 2-3 mixing from the
maximal one and to the CP-phase. We evaluate significance of the measurements
of the neutrino parameters and explore dependence of this significance on the
accuracy of reconstruction of the neutrino energy and direction. The effect of
degeneracy of the parameters on the sensitivities is also discussed. We
estimate the characteristics of future detectors (energy and angle resolution,
volume, etc.) required for establishing the neutrino mass hierarchy with high
confidence level. We find that the hierarchy can be identified at --
level (depending on the reconstruction accuracies) after 5 years of
PINGU operation.Comment: 39 pages, 21 figures. Description of Fig.3 correcte
Neutrino oscillations: Quantum mechanics vs. quantum field theory
A consistent description of neutrino oscillations requires either the
quantum-mechanical (QM) wave packet approach or a quantum field theoretic (QFT)
treatment. We compare these two approaches to neutrino oscillations and discuss
the correspondence between them. In particular, we derive expressions for the
QM neutrino wave packets from QFT and relate the free parameters of the QM
framework, in particular the effective momentum uncertainty of the neutrino
state, to the more fundamental parameters of the QFT approach. We include in
our discussion the possibilities that some of the neutrino's interaction
partners are not detected, that the neutrino is produced in the decay of an
unstable parent particle, and that the overlap of the wave packets of the
particles involved in the neutrino production (or detection) process is not
maximal. Finally, we demonstrate how the properly normalized oscillation
probabilities can be obtained in the QFT framework without an ad hoc
normalization procedure employed in the QM approach.Comment: LaTeX, 42 pages, 1 figure; v2: minor clarifications, matches
published version; v3: Corrected the discussion of the conditions under which
an oscillation probability can be sensibly defined in the QFT approach (sec.
5.2.4
Mesenchymal stromal cell delivery of full-length tumor necrosis factor-related apoptosis-inducing ligand is superior to soluble type for cancer therapy
Mesenchymal stromal cell (MSC) delivery of pro-apoptotic tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is an attractive strategy for anticancer therapy. MSCs expressing full-length human TRAIL (flT) or its soluble form (sT) have previously been shown to be effective for cancer killing. However, a comparison between the two forms has never been performed, leaving it unclear which approach is most effective. This study addresses the issue for the possible clinical application of TRAIL-expressing MSCs in the future
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