Seismic evidence for a lower-mantle origin of the Iceland plume

Iceland, one of the most thoroughly investigated hotspots1,2,3, is generally accepted to be the manifestation of an upwelling mantle plume4. Yet whether the plume originates from the lower mantle or from a convective instability at a thermal boundary layer between the upper and lower mantle near 660 km depth5,6 remains unconstrained. Tomographic inversions of body-wave delay times show that low seismic velocities extend to at least 400 km depth beneath central Iceland7,8, but cannot resolve structure at greater depth. Here we report lateral variations in the depths of compressional-to-shear wave conversions at the two seismic discontinuities marking the top and bottom of the mantle transition zone beneath Iceland. We find that the transition zone is 20 km thinner than in the average Earth9 beneath central and southern Iceland, but is of normal thickness beneath surrounding areas, a result indicative of a hot and narrow plume originating from the lower mantle.This work was supported by the US NSFPeer Reviewe

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size and shape change as people grow older and these changes differ substantially between men and women. To systematically screen for age-and/or sex-specific effects of genetic variants on BMI and WHRadjBMI, we performed meta-analyses of 114 studies (up to 320,485 individuals of European descent) with genome-wide chip and/or Metabochip data by the Genetic Investigation of Anthropometric Traits (GIANT) Consortium. Each study tested the association of up to similar to 2.8M SNPs with BMI and WHRadjBMI in four strata (men &lt;= 50y, men &gt; 50y, women &lt;= 50y, women &gt; 50y) and summary statistics were combined in stratum-specific meta-analyses. We then screened for variants that showed age-specific effects (G x AGE), sex-specific effects (G x SEX) or age-specific effects that differed between men and women (G x AGE x SEX). For BMI, we identified 15 loci (11 previously established for main effects, four novel) that showed significant (FDR&lt; 5%) age-specific effects, of which 11 had larger effects in younger (&lt; 50y) than in older adults (&gt;= 50y). No sex-dependent effects were identified for BMI. For WHRadjBMI, we identified 44 loci (27 previously established for main effects, 17 novel) with sex-specific effects, of which 28 showed larger effects in women than in men, five showed larger effects in men than in women, and 11 showed opposite effects between sexes. No age-dependent effects were identified for WHRadjBMI. This is the first genome-wide interaction meta-analysis to report convincing evidence of age-dependent genetic effects on BMI. In addition, we confirm the sex-specificity of genetic effects on WHRadjBMI. These results may providefurther insights into the biology that underlies weight change with age or the sexually dimorphism of body shape.</p