264 research outputs found
Histology in 3D:development of an online interactive student resource on epithelium
Epithelium is an important and highly specialised tissue type that makes up the lining of inner and outer surfaces of the human body. It is proposed that a self-study tool adds to efficient learning and lecturing on this complicated topic in medical curricula. This paper describes the development and evaluation of an online interactive 3D resource on epithelium for undergraduate medical students. A first evaluation was carried out by means of an online survey (n = 37). The resource was evaluated positively on the website in general, its visual contents and its value and potential for the medical curriculum
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Examining Rhodium Catalyst complexes for Use with Conducting Polymers Designed for Fuel Cells in Preparing Biosensors
Biosensing devices are important because they can detect, record, and transmit information regarding the presence of, or physiological changes in, different chemical or biological materials in the environment. The goal of this research is to prepare a biosensing device that is effective, quick, and low cost. This is done by examining which chemicals will work best when placed in a biosensor. The first study involved experimenting on a rhodium catalyst complexed with ligands such as bipyridine and imidazole. The rhodium catalyst is important because it is reduced from RhIII to RhI, forms a hydride by reaction with water and releases the hydride to react with nicotinamide adenine dinucleotide (NAD+) to selectively produce 1,4-NADH, the reduced form of NAD+. The second study looked at different types of ketones and enzymes for the enzyme-substrate reaction converting a ketone into an alcohol. Preliminary results showed that the rhodium complexed with bipyridine was able to carry out all the reactions, while the rhodium complexed with imidazole was not able to produce and release hydrides. In addition, the most effective ketone to use is benzylacetone with the enzyme alcohol dehydrogenase from baker’s yeast. Future work includes experimenting with bis-imidazole, which mimics the structure of bipyridine to see if it has the capability to reduce and if the reduction rate is comparable to the bipyridine complex. Once all testing is completed, the fastest catalysts will be combined with polymer membranes designed for fuel cells to prepare biosensing devices that can be used in a variety of applications including ones in the medical and environmental fields
Exterior and interior metrics with quadrupole moment
We present the Ernst potential and the line element of an exact solution of
Einstein's vacuum field equations that contains as arbitrary parameters the
total mass, the angular momentum, and the quadrupole moment of a rotating mass
distribution. We show that in the limiting case of slowly rotating and slightly
deformed configuration, there exists a coordinate transformation that relates
the exact solution with the approximate Hartle solution. It is shown that this
approximate solution can be smoothly matched with an interior perfect fluid
solution with physically reasonable properties. This opens the possibility of
considering the quadrupole moment as an additional physical degree of freedom
that could be used to search for a realistic exact solution, representing both
the interior and exterior gravitational field generated by a self-gravitating
axisymmetric distribution of mass of perfect fluid in stationary rotation.Comment: Latex, 15 pages, 3 figures, final versio
Evolution of virulence: triggering host inflammation allows invading pathogens to exclude competitors.
Virulence is generally considered to benefit parasites by enhancing resource-transfer from host to pathogen. Here, we offer an alternative framework where virulent immune-provoking behaviours and enhanced immune resistance are joint tactics of invading pathogens to eliminate resident competitors (transferring resources from resident to invading pathogen). The pathogen wins by creating a novel immunological challenge to which it is already adapted. We analyse a general ecological model of 'proactive invasion' where invaders not adapted to a local environment can succeed by changing it to one where they are better adapted than residents. However, the two-trait nature of the 'proactive' strategy (provocation of, and adaptation to environmental change) presents an evolutionary conundrum, as neither trait alone is favoured in a homogenous host population. We show that this conundrum can be resolved by allowing for host heterogeneity. We relate our model to emerging empirical findings on immunological mediation of parasite competition
Effects of acceleration on the collision of particles in the rotating black hole spacetime
We study the collision of two geodesic particles in the accelerating and
rotating black hole spacetime and probe the effects of the acceleration of
black hole on the center-of-mass energy of the colliding particles and on the
high-velocity collision belts. We find that the dependence of the
center-of-mass energy on the acceleration in the near event-horizon collision
is different from that in the near acceleration-horizon case. Moreover, the
presence of the acceleration changes the shape and position of the
high-velocity collision belts. Our results show that the acceleration of black
holes brings richer physics for the collision of particles.Comment: 7 pages, 2 figures, The corrected version accepted for publication in
EPJ
A rotating three component perfect fluid source and its junction with empty space-time
The Kerr solution for empty space-time is presented in an ellipsoidally
symmetric coordinate system and it is used to produce generalised ellipsoidal
metrics appropriate for the generation of rotating interior solutions of
Einstein's equations. It is shown that these solutions are the familiar static
perfect fluid cases commonly derived in curvature coordinates but now endowed
with rotation. The resulting solutions are also discussed in the context of
T-solutions of Einstein's equations and the vacuum T-solution outside a
rotating source is presented. The interior source for these solutions is shown
not to be a perfect fluid but rather an anisotropic three component perfect
fluid for which the energy momentum tensor is derived. The Schwarzschild
interior solution is given as an example of the approach.Comment: 14 page
Effect of liraglutide on cardiovascular outcomes in elderly patients: A post hoc analysis of a randomized controlled trial
Background: Comorbidities and complications associ-ated with type 2 diabetes mellitus (T2DM) increase with age, making treatment of elderly persons with this condition chal-lenging. Clinical data on the effect of antihyperglycemic treat-ment on cardiovascular (CV) events in elderly persons are limited (1). The U.S. Food and Drug Administration and Euro-pean Medicines Agency recommend collecting comprehen-sive data on elderly patients with diabetes, particularly those aged 75 years or older, to inform appropriate treatment of this growing populatio
One-dimensional quantum channel and Hawking radiation of the Kerr and Kerr-Newman black holes
In this paper, we review the one-dimensional quantum channel and investigate
Hawking radiation of bosons and fermions in Kerr and Kerr-Newman black holes.
The result shows the Hawking radiation can be described by the quantum channel.
The thermal conductances are derived and related to the black holes'
temperatures.Comment: V2, 12 pages. Typo correcte
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