8 research outputs found
Exclusion of identified LGMD1 loci from four dominant limb-girdle muscular dystrophy families
No full textPossible interaction of genotypes at cystathionine ÎČ-synthase and methylenetetrahydrofolate reductase (MTHFR) in neural tube defects
No full textSurface hardness as a proxy for weathering behaviour of limestone heritage: a case study on dated headstones on the Isle of Portland, UK
No full textSedimentology of geomorphologically controlled Quaternary tufas in a valley in southern Spain
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The many faces of Reigate Stone: an assessment of variability in historic masonry based on Medieval Londonâs principal freestone
No full textThe atheroprotective properties of Hsp70: a role for Hsp70-endothelial interactions?
No full textAlthough heat shock (stress) proteins are typically regarded as being exclusively intracellular molecules, it is now apparent that they can be released from cells in the absence of cellular necrosis. We and others have reported the presence of Hsp60 (HSPD1) and Hsp70 (HSPA1A) in the circulation of normal individuals and our finding that increases in carotid intima-media thicknesses (a measure of atherosclerosis) in subjects with hypertension at a 4-year follow-up are less prevalent in those having high serum Hsp70 (HSPA1A) levels at baseline suggests that circulating Hsp70 (HSPA1A) has atheroprotective effects. Given that circulating Hsp70 (HSPA1A) levels can be in the range which has been shown to elicit a number of biological effects in vitro, and our preliminary findings that Hsp70 (HSPA1A) binds to and is internalised by human endothelial cell populations, we speculate on the mechanisms that might be involved in the apparent atheroprotective properties of this protein
