Nuclear Wavepacket Dynamics of Alkali Adsorbates on Metal Surfaces Studied by Time-Resolved Second Harmonic Generation

This paper reviews recent efforts to understand the dynamics of coherent surface vibrations of alkali atoms adsorbed on metal surfaces. Time-resolved second harmonic generation is used for the coherent excitation and detection of the nuclear wavepacket dynamics of the surface modes. The principles of the measurement and the experimental details are described. The main focus is on coverage and excitation photon energy dependences of the coherent phonon dynamics for Na-, K-, and Cs-covered Cu(111). The excitation mechanism of the coherent phonon has been revealed by the ultrafast time-domain technique and theoretical modelings

Photodynamic Inactivation of <em>Escherichia coli</em> with Cationic Porphyrin Sensitizers

The activity of singlet-oxygen sensitizers for photodynamic inactivation (PDI) of microorganisms and photodynamic therapy of tumor cells has been evaluated using Escherichia coli, Saccharomyces cerevisiae, and human cancer cell lines. In this chapter, drug resistance of E. coli was examined based on the PDI activity of a variety of RPy-P-porphyrin sensitizers with different number of ionic valence and different hydrophobic characters. The PDI activities toward E. coli were evaluated using the minimum effective concentrations ([P]) of the porphyrin sensitizers. It was found that the [P] value for E. coli was larger than that for S. cerevisiae. E. coli has drug-resistance toward hydrophobic and mono-cationic porphyrins. However, E. coli has weak drug-resistance toward the porphyrins with both polycationic character and hydrophobicity. Since the outer membrane mainly consists of lipopolysaccharides and phospholipids that are negatively charged, cationic porphyrins are able to adsorb to the outer leaflet. Then the cationic porphyrins with hydrophobic character can interact with not only the outer leaflet but also inner leaflet of the outer membrane and the plasma membrane. Thus, porphyrins may be incorporated inside E. coli cells via the self-promoted uptake pathway. Moreover, polycationic porphyrins can interact with DNA and proteins by strong binding affinities

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Rotationally-Driven Fragmentation for the Formation of the Binary Protostellar System L1551 IRS 5

Either bulk rotation or local turbulence is widely invoked to drive fragmentation in collapsing cores so as to produce multiple star systems. Even when the two mechanisms predict different manners in which the stellar spins and orbits are aligned, subsequent internal or external interactions can drive multiple systems towards or away from alignment thus masking their formation process. Here, we demonstrate that the geometrical and dynamical relationship between the binary system and its surrounding bulk envelope provide the crucial distinction between fragmentation models. We find that the circumstellar disks of the binary protostellar system L1551 IRS 5 are closely parallel not just with each other but also with their surrounding flattened envelope. Measurements of the relative proper motion of the binary components spanning nearly 30 yr indicate an orbital motion in the same sense as the envelope rotation. Eliminating orbital solutions whereby the circumstellar disks would be tidally truncated to sizes smaller than are observed, the remaining solutions favor a circular or low-eccentricity orbit tilted by up to $\sim$25$^\circ$ from the circumstellar disks. Turbulence-driven fragmentation can generate local angular momentum to produce a coplanar binary system, but which bears no particular relationship with its surrounding envelope. Instead, the observed properties conform with predictions for rotationally-driven fragmentation. If the fragments were produced at different heights or on opposite sides of the midplane in the flattened central region of a rotating core, the resulting protostars would then exhibit circumstellar disks parallel with the surrounding envelope but tilted from the orbital plane as is observed.Comment: Accepted for publication in Ap

Iodo-Nonoxynol-9-Derivatives and Methods for Their Use

Mono- and di-iodinated nonoxynol-9-derivatives and methods for their use are disclosed

Angular Momentum Exchange by Gravitational Torques and Infall in the Circumbinary Disk of the Protostellar System L1551 NE

We report the ALMA observation of the Class I binary protostellar system L1551 NE in the 0.9-mm continuum, C18O (3-2), and 13CO (3-2) lines at a ~1.6 times higher resolution and a ~6 times higher sensitivity than those of our previous SMA observations, which revealed a r ~300 AU-scale circumbinary disk in Keplerian rotation. The 0.9-mm continuum shows two opposing U-shaped brightenings in the circumbinary disk, and exhibits a depression between the circumbinary disk and the circumstellar disk of the primary protostar. The molecular lines trace non-axisymmetric deviations from Keplerian rotation in the circumbinary disk at higher velocities relative to the systemic velocity, where our previous SMA observations could not detect the lines. In addition, we detect inward motion along the minor axis of the circumbinary disk. To explain the newly-observed features, we performed a numerical simulation of gas orbits in a Roche potential tailored to the inferred properties of L1551 NE. The observed U-shaped dust features coincide with locations where gravitational torques from the central binary system are predicted to impart angular momentum to the circumbinary disk, producing shocks and hence density enhancements seen as a pair of spiral arms. The observed inward gas motion coincides with locations where angular momentum is predicted to be lowered by the gravitational torques. The good agreement between our observation and model indicates that gravitational torques from the binary stars constitute the primary driver for exchanging angular momentum so as to permit infall through the circumbinary disk of L1551 NE.Comment: 38 pages, 11 figures, accepted for publication in Ap