92 research outputs found
α-Fetoprotein Messenger RNA in the Blood Predicts Poor Prognosis of the Patients with Hepatocellular Carcinoma
α-Fetoprotein (AFP) messenger RNA (mRNA) in the peripheral blood of patients with hepatocellular carcinoma (HCC) may indicate hematogenous spread of HCC. This study examined the presence of AFP mRNA in the blood of 148 patients, in terms of clinical parameters, tumor metastasis and survival rate. For the prospective study, 109 patients with HCC were followed in the period between March 1996 and March 1999. AFP mRNA in the blood was examined by means of nested reverse transcription polymerase chain reaction. AFP mRNA was detected in the blood in 23 (15.5%) of 148 patients with HCC. AFP mRNA in the blood was significantly correlated with protein induced by vitamin K absence or antagonist II level, higher AFP level (200 IU/mL or more) and extrahepatic metastases, but not with tumor size, number of tumor nodules or tumor-nodule-metastasis stage. This prospective study confirmed that intra- and extra-hepatic metastases developed more frequently in the 22 AFP mRNA-positive patients than in the 87 AFP mRNA-negative patients (P < 0.01). The cumulative survival rate was significantly lower in the former than in the latter (P < 0.01). In conclusion, AFP mRNA in the blood is closely related to hematogenous spread and might be a good predictor of metastasis and poorer survival rate in HCC patients
The MAXI Mission on the ISS: Science and Instruments for Monitoring All Sky X-Ray Images
The MAXI (Monitor of All-sky X-ray Image) mission is the first astronomical
payload to be installed on the Japanese Experiment Module-Exposed Facility
(JEM-EF) on the ISS. It is scheduled for launch in the middle of 2009 to
monitor all-sky X-ray objects on every ISS orbit. MAXI will be more powerful
than any previous X-ray All Sky Monitor (ASM) payloads, being able to monitor
hundreds of AGN. MAXI will provide all sky images of X-ray sources of about 20
mCrab in the energy band of 2-30 keV from observation on one ISS orbit (90
min), about 4.5 mCrab for one day, and about 1 mCrab for one month. A final
detectability of MAXI could be 0.2 mCrab for 2 year observations.Comment: 12 pages, 11 figures, accepted for publication in Publications of the
Astronomical Society of Japa
Bright X-ray flares from the BL Lac object Mrk 421, detected with MAXI in 2010 January and February
Strong X-ray flares from the blazar Mrk 421 were detected in 2010 January and
February through the 7 month monitoring with the MAXI GSC. The maximum 2 -- 10
keV flux in the January and February flares was measured as 120 +- 10 mCrab and
164 +- 17 mCrab respectively; the latter is the highest among those reported
from the object. A comparison of the MAXI and Swift BAT data suggests a convex
X-ray spectrum with an approximated photon index of about 2. This spectrum is
consistent with a picture that MAXI is observing near the synchrotron peak
frequency. The source exhibited a spectral variation during these flares,
slightly different from those in the previous observations, in which the
positive correlation between the flux and hardness was widely reported. By
equating the halving decay timescale in the January flare, s, to the synchrotron cooling time, the magnetic field was
evaluated as B = 0.045 G , where is the jet
beaming factor. Assuming that the light crossing time of the emission region is
shorter than the doubling rise time, s,
the region size was roughly estimated as cm
. These are consistent with the values previously reported. For
the February flare, the rise time, s, gives a
loose upper limit on the size as cm ,
although the longer decay time s, indicates
B = 0.015 G , which is weaker than the previous results.
This could be reconciled by invoking a scenario that this flare is a
superposition of unresolved events with a shorter timescale.Comment: 14 pages, 4 figures, accepted for PASJ (Vol. 62 No. 6
MAXI GSC observations of a spectral state transition in the black hole candidate XTE J1752-223
We present the first results on the black hole candidate XTE J1752-223 from
the Gas Slit Camera (GSC) on-board the Monitor of All-sky X-ray Image (MAXI) on
the International Space Station. Including the onset of the outburst reported
by the Proportional Counter Array on-board the Rossi X-ray Timing Explorer on
2009 October 23, the MAXI/GSC has been monitoring this source approximately 10
times per day with a high sensitivity in the 2-20 keV band. XTE J1752-223 was
initially in the low/hard state during the first 3 months. An anti-correlated
behavior between the 2-4 keV and 4-20 keV bands were observed around January
20, 2010, indicating that the source exhibited the spectral transition to the
high/soft state. A transient radio jet may have been ejected when the source
was in the intermediate state where the spectrum was roughly explained by a
power-law with a photon index of 2.5-3.0. The unusually long period in the
initial low/hard state implies a slow variation in the mass accretion rate, and
the dramatic soft X-ray increase may be explained by a sudden appearance of the
accretion disk component with a relatively low innermost temperature (0.4-0.7
keV). Such a low temperature might suggest that the maximum accretion rate was
just above the critical gas evaporation rate required for the state transition.Comment: Publication of Astronomical Society of Japan Vol.62, No.5 (2010) [in
print
A Large X-ray Flare from a Single Weak-lined T Tauri Star TWA-7 Detected with MAXI GSC
We present a large X-ray flare from a nearby weak-lined T Tauri star TWA-7
detected with the Gas Slit Camera (GSC) on the Monitor of All-sky X-ray Image
(MAXI). The GSC captured X-ray flaring from TWA-7 with a flux of
ergs cm s in 2--20 keV band during the scan
transit starting at UT 2010-09-07 18:24:30.The estimated X-ray luminosity at
the scan in the energy band is 3 ergs s,indicating that
the event is among the largest X-ray flares fromT Tauri stars.Since MAXI GSC
monitors a target only during a scan transit of about a minute per 92 min
orbital cycle, the luminosity at the flare peak might have been higher than
that detected. At the scan transit, we observed a high X-ray-to-bolometric
luminosity ratio, log = ; i.e., the
X-ray luminosity is comparable to the bolometric luminosity. Since TWA-7 has
neither an accreting disk nor a binary companion, the observed event implies
that none of those are essential to generate such big flares in T Tauri stars.Comment: 4 pages, 2 figures, 1 table accepted for publication in PAS
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