25 research outputs found
Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses
To understand neurological complications of COVID-19 better both acutely and for recovery, we measured markers of brain injury, inflammatory mediators, and autoantibodies in 203 hospitalised participants; 111 with acute sera (1–11 days post-admission) and 92 convalescent sera (56 with COVID-19-associated neurological diagnoses). Here we show that compared to 60 uninfected controls, tTau, GFAP, NfL, and UCH-L1 are increased with COVID-19 infection at acute timepoints and NfL and GFAP are significantly higher in participants with neurological complications. Inflammatory mediators (IL-6, IL-12p40, HGF, M-CSF, CCL2, and IL-1RA) are associated with both altered consciousness and markers of brain injury. Autoantibodies are more common in COVID-19 than controls and some (including against MYL7, UCH-L1, and GRIN3B) are more frequent with altered consciousness. Additionally, convalescent participants with neurological complications show elevated GFAP and NfL, unrelated to attenuated systemic inflammatory mediators and to autoantibody responses. Overall, neurological complications of COVID-19 are associated with evidence of neuroglial injury in both acute and late disease and these correlate with dysregulated innate and adaptive immune responses acutely
Lists on Lists: A Framework for Self-organizing Lists in Environments with Locality of Reference
An Analysis of Literature Reviews on IS Business Value: How Deficiencies in Methodology and Theory Use Resulted in Limited Effectiveness
Enduring doubts about the value of IS investments reveal that IS
researchers have not fully managed to identify and to explain the economic benefits of IS. This paper assumes that literature reviews, which represent a powerful instrument for the identification and synthesis of knowledge, have not tapped their full potential to address this issue due to deficiencies in methodology. The analysis of 18 literature reviews published in pertinent academic outlets during the past 20 years shows such deficiencies. Two of the most critical weaknesses identified are (1) the lack of theory use in most reviews and (2) a weak linkage of reviews, resulting in little progress in theory and framework development. The systematic identification of these weaknesses and the extraction of promising methodological examples from past literature are the main contributions of this work, which supports the composition of more effective literature reviews in future research
Genetic control of 6-phosphogluconate dehydrogenase (6-PGD) isozymes in cultivated wheat and rye
Technological potential of under-utilized starches from eight varieties of legumes grown in Cameroon
Management of anaphylaxis due to COVID-19 vaccines in the elderly
Older adults, especially men and/or those with diabetes, hypertension, and/or obesity, are prone to severe COVID-19. In some countries, older adults, particularly those residing in nursing homes, have been prioritized to receive COVID-19 vaccines due to high risk of death. In very rare instances, the COVID-19 vaccines can induce anaphylaxis, and the management of anaphylaxis in older people should be considered carefully. An ARIA-EAACI-EuGMS (Allergic Rhinitis and its Impact on Asthma, European Academy of Allergy and Clinical Immunology, and European Geriatric Medicine Society) Working Group has proposed some recommendations for older adults receiving the COVID-19 vaccines. Anaphylaxis to COVID-19 vaccines is extremely rare (from 1 per 100,000 to 5 per million injections). Symptoms are similar in younger and older adults but they tend to be more severe in the older patients. Adrenaline is the mainstay treatment and should be readily available. A flowchart is proposed to manage anaphylaxis in the older patients. © 2021 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd