648 research outputs found
Multiple stressor effects of radon and phthalates in children: background information and future research
The present paper reviews available background information for studying multiple stressor effects of radon (222Rn) and phthalates in children and provides insights on future directions. In realistic situations, living organisms are collectively subjected to many environmental stressors, with the resultant effects being referred to as multiple stressor effects. Radon is a naturally occurring radioactive gas that can lead to lung cancers. On the other hand, phthalates are semi-volatile organic compounds widely applied as plasticizers to provide flexibility to plastic in consumer products. Links of phthalates to various health effects have been reported, including allergy and asthma. In the present review, the focus on indoor contaminants was due to their higher concentrations and to the higher indoor occupancy factor, while the focus on the pediatric population was due to their inherent sensitivity and their spending more time close to the floor. Two main future directions in studying multiple stressor effects of radon and phthalates in children were proposed. The first one was on computational modeling and micro-dosimetric studies, and the second one was on biological studies. In particular, dose-response relationship and effect-specific models for combined exposures to radon and phthalates would be necessary. The ideas and methodology behind such proposed research work are also applicable to studies on multiple stressor effects of collective exposures to other significant airborne contaminants, and to population groups other than children
Long-term passive monitoring of solar UV radiation using radiochromic films
Paper presented to the 3rd Southern African Solar Energy Conference, South Africa, 11-13 May, 2015.The solar ultraviolet (UV) spectrum spans over a range of wavelengths, namely, UVA (315–400 nm), UVB (280–315 nm) and UVC (100–280 nm). The UV radiation reaching the surface of the Earth comprises of mainly UVA, a small amount of UVB and essentially no UVC. Solar UV can affect the human health. An under-dose will lead to diseases such as rickets and osteoporosis, while an over-dose will cause sunburns, skin cancers and cataracts. It is therefore pertinent to design methods for integrated long-term measurements of UV radiation (e.g., over 1 day). Recently, we succeeded in demonstrating the feasibility of using the Gafchromic EBT3 radiochromic film to quantify solar (UVA+UVB) exposures (in Jcm-2). These radiochromic-film products were originally developed for clinical dosimetric applications, with visible-light absorption changes upon X-ray irradiation, but were understood to be also responsive to UV radiations. We found that the usable range of UV exposures for the EBT3 film was from ~0.2 to ~30 Jcm-2. However, the maximum UV exposure could reach 50 Jcm-2 per day, so we need a wider usable range. The current work proposed modifications to the EBT3 film for longer-term measurements (e.g., over 1 day). We explored the UV responses of EBT3 films covered with 2 and 5 barriers, each barrier being a blue polypropylene film with a thickness of 0.3 mm. The usable range for the film with 2 barriers was from ~4 to ~40 Jcm-2, while the usable range for the film with 5 barriers was from ~30 to ~300 Jcm-2. Using both EBT3 films covered with 2 and 5 barriers will give a continuous usable range from 4 to 300 Jcm-2, which will be useful for a consecutive 6-d UV exposure measurement.cf201
Sub-Poissonian statistics in order-to-chaos transition
We study the phenomena at the overlap of quantum chaos and nonclassical
statistics for the time-dependent model of nonlinear oscillator. It is shown in
the framework of Mandel Q-parameter and Wigner function that the statistics of
oscillatory excitation number is drastically changed in order-to chaos
transition. The essential improvement of sub-Poissonian statistics in
comparison with an analogous one for the standard model of driven anharmonic
oscillator is observed for the regular operational regime. It is shown that in
the chaotic regime the system exhibits the range of sub- and super-Poissonian
statistics which alternate one to other depending on time intervals. Unusual
dependence of the variance of oscillatory number on the external noise level
for the chaotic dynamics is observed.Comment: 9 pages, RevTeX, 14 figure
An implicit algorithm of solving Navier–Stokes equations to simulate flows in anisotropic porous media
Gating a Single Cell:A Label-Free and Real-Time Measurement Method for Cellular Progression
There is an ever-growing need for more advanced methods to study the response of cancer cells to new therapies. To determine cancer cells’ response from a cell-mortality perspective to various cancer therapies, we report a label-free and real time method to monitor the in situ response of individual HeLa cells using a single cell gated transistor (SCGT). As a cell undergoes apoptotic cell death, it experiences changes in morphology and ion concentrations. This change is well in line with the threshold voltage of the SCGT, which has been verified by correlating the data with the cell morphologies by scanning electron microscopy and the ion-concentration analysis by inductively-coupled plasma mass spectrometry (ICPMS). This SCGT could replace patch clamps to study single cell activity via direct measurement in real time. Importantly, this SCGT can be used to study the electrical response of a single cell to stimuli that leaves the membrane intact
Single- and multi-walled carbon nanotubes viewed as elastic tubes with Young's moduli dependent on layer number
The complete energy expression of a deformed single-walled carbon nanotube
(SWNT) is derived in the continuum limit from the local density approximation
model proposed by Lenosky {\it et al.} \lbrack Nature (London) {\bf 355}, 333
(1992)\rbrack and shows to be content with the classic shell theory by which
the Young's modulus, the Poisson ratio and the effective wall thickness of
SWNTs are obtained as TPa, , , respectively.
The elasticity of a multi-walled carbon nanotube (MWNT) is investigated as the
combination of the above SWNTs of layer distance and the
Young's modulus of the MWNT is found to be an apparent function of the number
of layers, , varying from 4.70TPa to 1.04TPa for N=1 to .Comment: 4 pages, 1 figur
Self-induced and induced transparencies of two-dimensional and three- dimensional superlattices
The phenomenon of transparency in two-dimensional and three-dimensional
superlattices is analyzed on the basis of the Boltzmann equation with a
collision term encompassing three distinct scattering mechanisms (elastic,
inelastic and electron-electron) in terms of three corresponding distinct
relaxation times. On this basis, we show that electron heating in the plane
perpendicular to the current direction drastically changes the conditions for
the occurrence of self-induced transparency in the superlattice. In particular,
it leads to an additional modulation of the current amplitudes excited by an
applied biharmonic electric field with harmonic components polarized in
orthogonal directions. Furthermore, we show that self-induced transparency and
dynamic localization are different phenomena with different physical origins,
displaced in time from each other, and, in general, they arise at different
electric fields.Comment: to appear in Physical Review
On the Three-dimensional Central Moment Lattice Boltzmann Method
A three-dimensional (3D) lattice Boltzmann method based on central moments is
derived. Two main elements are the local attractors in the collision term and
the source terms representing the effect of external and/or self-consistent
internal forces. For suitable choices of the orthogonal moment basis for the
three-dimensional, twenty seven velocity (D3Q27), and, its subset, fifteen
velocity (D3Q15) lattice models, attractors are expressed in terms of
factorization of lower order moments as suggested in an earlier work; the
corresponding source terms are specified to correctly influence lower order
hydrodynamic fields, while avoiding aliasing effects for higher order moments.
These are achieved by successively matching the corresponding continuous and
discrete central moments at various orders, with the final expressions written
in terms of raw moments via a transformation based on the binomial theorem.
Furthermore, to alleviate the discrete effects with the source terms, they are
treated to be temporally semi-implicit and second-order, with the implicitness
subsequently removed by means of a transformation. As a result, the approach is
frame-invariant by construction and its emergent dynamics describing fully 3D
fluid motion in the presence of force fields is Galilean invariant. Numerical
experiments for a set of benchmark problems demonstrate its accuracy.Comment: 55 pages, 8 figure
Assessing the utility of low resolution brain imaging: treatment of infant hydrocephalus
As low-field MRI technology is being disseminated into clinical settings around the world, it is important to assess the image quality required to properly diagnose and treat a given disease and evaluate the role of machine learning algorithms, such as deep learning, in the enhancement of lower quality images. In this post hoc analysis of an ongoing randomized clinical trial, we assessed the diagnostic utility of reduced-quality and deep learning enhanced images for hydrocephalus treatment planning. CT images of post-infectious infant hydrocephalus were degraded in terms of spatial resolution, noise, and contrast between brain and CSF and enhanced using deep learning algorithms. Both degraded and enhanced images were presented to three experienced pediatric neurosurgeons accustomed to working in low-to middle-income countries (LMIC) for assessment of clinical utility in treatment planning for hydrocephalus. In addition, enhanced images were presented alongside their ground truth CT counterparts in order to assess whether reconstruction errors caused by the deep learning enhancement routine were acceptable to the evaluators. Results indicate that image resolution and contrast-to-noise ratio between brain and CSF predict the likelihood of an image being characterized as useful for hydrocephalus treatment planning. Deep learning enhancement substantially increases contrast-to-noise ratio improving the apparent likelihood of the image being useful; however, deep learning enhancement introduces structural errors which create a substantial risk of misleading clinical interpretation. We find that images with lower quality than is customarily acceptable can be useful for hydrocephalus treatment planning. Moreover, low quality images may be preferable to images enhanced with deep learning, since they do not introduce the risk of misleading information which could misguide treatment decisions. These findings advocate for new standards in assessing acceptable image quality for clinical use.Neuro Imaging Researc
A new measurement of direct CP violation in two pion decays of the neutral kaon
The NA48 experiment at CERN has performed a new measurement of direct CP
violation, based on data taken in 1997 by simultaneously collecting K_L and K_S
decays into pi0pi0 and pi+pi-. The result for the CP violating parameter
Re(epsilon'/epsilon) is (18.5 +/- 4.5(stat)} +/- 5.8 (syst))x10^{-4}.Comment: 18 pages, 6 figure
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