Monitoring mouse retinal degeneration with high-resolution spectral-domain optical coherence tomography

Progression of retinal degeneration in a mouse model was studied in vivo with high-resolution spectral-domain optical coherence tomography (SD-OCT). Imaging in 3D with high depth resolution (<3 mu m), SD-OCT resolved all the major layers of the retina of control C57BL/6J mice. Images of transgenic mice having a null mutation of the rhodopsin gene revealed the anatomical consequences of retinal degeneration: thinning of the outer retina, including the outer plexiform layer (OPL), outer nuclear layer (ONL), and inner and outer segments (IS/OS). We monitored the progression of retinal degeneration in rd1 mice (C3H/HeJ) by periodically imaging the same mice from the time the pups opened their eyes on P13 to P34. SD-OCT images showed that the outer retina (OPL, ONL, IS/OS) had already thinned by 73% (100 to 27 mu m) at eye opening. The retina continued to degenerate, and by P20 the outer retina was not resolvable. The thickness of entire retina decreased from 228 mu m (control) to 152 mu m on P13 and to 98 mu m by P34, a 57% reduction with the complete loss in the outer retina. In summary, we show that SD-OCT can monitor the progression of retinal degeneration in transgenic mice.X114367sciescopu

Landau Expansion for the Kugel-Khomskii t2gt_{2g} Hamiltonian

The Kugel-Khomskii (KK) Hamiltonian for the titanates describes spin and orbital superexchange interactions between $d^1$ ions in an ideal perovskite structure in which the three $t_{2g}$ orbitals are degenerate in energy and electron hopping is constrained by cubic site symmetry. In this paper we implement a variational approach to mean-field theory in which each site, $i$, has its own $n \times n$ single-site density matrix \rhov(i), where $n$, the number of allowed single-particle states, is 6 (3 orbital times 2 spin states). The variational free energy from this 35 parameter density matrix is shown to exhibit the unusual symmetries noted previously which lead to a wavevector-dependent susceptibility for spins in $\alpha$ orbitals which is dispersionless in the $q_\alpha$-direction. Thus, for the cubic KK model itself, mean-field theory does not provide wavevector `selection', in agreement with rigorous symmetry arguments. We consider the effect of including various perturbations. When spin-orbit interactions are introduced, the susceptibility has dispersion in all directions in ${\bf q}$-space, but the resulting antiferromagnetic mean-field state is degenerate with respect to global rotation of the staggered spin, implying that the spin-wave spectrum is gapless. This possibly surprising conclusion is also consistent with rigorous symmetry arguments. When next-nearest-neighbor hopping is included, staggered moments of all orbitals appear, but the sum of these moments is zero, yielding an exotic state with long-range order without long-range spin order. The effect of a Hund's rule coupling of sufficient strength is to produce a state with orbital order.Comment: 20 pages, 5 figures, submitted to Phys. Rev. B (2003

Electromagnetic properties of graphene junctions

A resonant chiral tunneling (CT) across a graphene junction (GJ) induced by an external electromagnetic field (EF) is studied. Modulation of the electron and hole wavefunction phases $\varphi$ by the external EF during the CT processes strongly impacts the CT directional diagram. Therefore the a.c. transport characteristics of GJs depend on the EF polarization and frequency considerably. The GJ shows great promises for various nanoelectronic applications working in the THz diapason.Comment: 4 pages 3 figure

Three dimensional tracking for volumetric spectral-domain optical coherence tomography

We present a three-dimensional (3D) tracker for a clinical ophthalmic spectral domain optical coherence tomography (SD-OCT) system that combines depth-tracking with lateral tracking, providing a stabilized reference frame for 3D data recording and post acquisition analysis. The depth-tracking system is implemented through a real-time dynamic feedback mechanism to compensate for motion artifact in the axial direction. Active monitoring of the retina and adapting the reference arm of the interferometer allowed the whole thickness of the retina to be stabilized to within +/- 100 mu m. We achieve a relatively constant SNR from image to image by stabilizing the image of the retina with respect to the depth dependent sensitivity of SD-OCT. The depth tracking range of our system is 5.2 mm in air and the depth is adjusted every frame. Enhancement in the stability of the images with the depth-tracking algorithm is demonstrated on a healthy volunteer.X1119sciescopu

Vortex structure in d-density wave scenario of pseudogap

We investigate the vortex structure assuming the d-density wave scenario of the pseudogap. We discuss the profiles of the order parameters in the vicinity of the vortex, effective vortex charge and the local density of states. We find a pronounced modification of these quantities when compared to a purely superconducting case. Results have been obtained for a clean system as well as in the presence of a nonmagnetic impurity. We show that the competition between superconductivity and the density wave may explain some experimental data recently obtained for high-temperature superconductors. In particular, we show that the d-density wave scenario explains the asymmetry of the gap observed in the vicinity of the vortex core.Comment: 8 pages, 10 figure

Geometry and cosmological perturbations in the bulk inflaton model

We consider a braneworld inflation model driven by the dynamics of a scalar field living in the 5-dimensional bulk, the so-called ``bulk inflaton model'', and investigate the geometry in the bulk and large scale cosmological perturbations on the brane. The bulk gravitational effects on the brane are described by a projection of the 5-dimensional Weyl tensor, which we denote by $E_{\mu\nu}$. Focusing on a tachionic potential model, we take a perturbative approach in the anti-de Sitter (AdS$_5$) background with a single de Sitter brane. We first formulate the evolution equations for $E_{\mu\nu}$ in the bulk. Next, applying them to the case of a spatially homogeneous brane, we obtain two different integral expressions for $E_{\mu\nu}$. One of them reduces to the expression obtained previously when evaluated on the brane. The other is a new expression that may be useful for analyzing the bulk geometry. Then we consider superhorizon scale cosmological perturbations and evaluate the bulk effects onto the brane. In the limit $H^2\ell^2\ll1$, where $H$ is the Hubble parameter on the brane and $\ell$ is the bulk curvature radius, we find that the effective theory on the brane is identical to the 4-dimensional Einstein-scalar theory with a simple rescaling of the potential even under the presence of inhomogeneities. % atleast on super-Hubble horizon scales. In particular, it is found that the anticipated non-trivial bulk effect due to the spatially anisotropic part of $E_{\mu\nu}$ may appear only at %second order in the low energy expansion, i.e., at $O(H^4\ell^4)$.Comment: 21 pages including 6 pages for several appendixes, no figure

Dynamical mean-field approach to materials with strong electronic correlations

We review recent results on the properties of materials with correlated electrons obtained within the LDA+DMFT approach, a combination of a conventional band structure approach based on the local density approximation (LDA) and the dynamical mean-field theory (DMFT). The application to four outstanding problems in this field is discussed: (i) we compute the full valence band structure of the charge-transfer insulator NiO by explicitly including the p-d hybridization, (ii) we explain the origin for the simultaneously occuring metal-insulator transition and collapse of the magnetic moment in MnO and Fe2O3, (iii) we describe a novel GGA+DMFT scheme in terms of plane-wave pseudopotentials which allows us to compute the orbital order and cooperative Jahn-Teller distortion in KCuF3 and LaMnO3, and (iv) we provide a general explanation for the appearance of kinks in the effective dispersion of correlated electrons in systems with a pronounced three-peak spectral function without having to resort to the coupling of electrons to bosonic excitations. These results provide a considerable progress in the fully microscopic investigations of correlated electron materials.Comment: 24 pages, 14 figures, final version, submitted to Eur. Phys. J. for publication in the Special Topics volume "Cooperative Phenomena in Solids: Metal-Insulator Transitions and Ordering of Microscopic Degrees of Freedom

Stable, Time-Dependent, Exact Solutions for Brane Models with a Bulk Scalar Field

We derive two classes of brane-world solutions arising in the presence of a bulk scalar field. For static field configurations, we adopt a time-dependent, factorizable metric ansatz that allows for radion stabilization. The solutions are characterized by a non-trivial warping along the extra dimension, even in the case of a vanishing bulk cosmological constant, and lead to a variety of inflationary, time-dependent solutions of the 3D scale factor on the brane. We also derive the constraints necessary for the stability of these solutions under time-dependent perturbations of the radion field, and we demonstrate the existence of phenomenologically interesting, stable solutions with a positive cosmological constant on the brane.Comment: 24 pages, latex, 4 eps figur

Caustic avoidance in Horava-Lifshitz gravity

There are at least four versions of Horava-Lishitz gravity in the literature. We consider the version without the detailed balance condition with the projectability condition and address one aspect of the theory: avoidance of caustics for constant time hypersurfaces. We show that there is no caustic with plane symmetry in the absence of matter source if \lambda\ne 1. If \lambda=1 is a stable IR fixed point of the renormalization group flow then \lambda is expected to deviate from 1 near would-be caustics, where the extrinsic curvature increases and high-energy corrections become important. Therefore, the absence of caustics with \lambda\ne 1 implies that caustics cannot form with this symmetry in the absence of matter source. We argue that inclusion of matter source will not change the conclusion. We also argue that caustics with codimension higher than one will not form because of repulsive gravity generated by nonlinear higher curvature terms. These arguments support our conjecture that there is no caustic for constant time hypersurfaces. Finally, we discuss implications to the recently proposed scenario of ``dark matter as integration constant''.Comment: 19 pages; extended to general z \geq 3, typos corrected (v2); version accepted for publication in JCAP (v3

Exclusive electroproduction of K+ Lambda and K+ Sigma^0 final states at Q^2 = 0.030-0.055 (GeV/c)^2

Cross section measurements of the exclusive p(e,e'K+)Lambda,Sigma^0 electroproduction reactions have been performed at the Mainz Microtron MAMI in the A1 spectrometer facility using for the first time the Kaos spectrometer for kaon detection. These processes were studied in a kinematical region not covered by any previous experiment. The nucleon was probed in its third resonance region with virtual photons of low four-momenta, Q^2= 0.030-0.055 (GeV/c)^2. The MAMI data indicate a smooth transition in Q^2 from photoproduction to electroproduction cross sections. Comparison with predictions of effective Lagrangian models based on the isobar approach reveal that strong longitudinal couplings of the virtual photon to the N* resonances can be excluded from these models.Comment: 16 pages, 7 figure