593 research outputs found
S=1 kagom\'e Ising model with triquadratic interactions, single-ion anisotropy and magnetic field: exact phase diagrams
We consider a S=1 kagom\'e Ising model with triquadratic interactions around
each triangular face of the kagom\'e lattice, single-ion anisotropy and an
applied magnetic field. A mapping establishes an equivalence between the
magnetic canonical partition function of the model and the grand canonical
partition function of a kagom\'e lattice-gas model with localized
three-particle interactions. Since exact phase diagrams are known for
condensation in the one-parameter lattice-gas model, the mapping directly
provides the corresponding exact phase diagrams of the three-parameter S=1
Ising model. As anisotropy competes with interactions, results include the
appearance of confluent singularities effecting changes in the topology of the
phase diagrams, phase boundary curves (magnetic field vs temperature) with
purely positive or negative slopes as well as intermediate cases showing
nonmonotonicity, and coexistence curves (magnetization vs temperature) with
varying shapes and orientations, in some instances entrapping a homogeneous
phase.Comment: 14 pages plus 11 figures; to be published in Physica
On the stability of scalar-vacuum space-times
We study the stability of static, spherically symmetric solutions to the
Einstein equations with a scalar field as the source. We describe a general
methodology of studying small radial perturbations of scalar-vacuum
configurations with arbitrary potentials V(\phi), and in particular space-times
with throats (including wormholes), which are possible if the scalar is
phantom. At such a throat, the effective potential for perturbations V_eff has
a positive pole (a potential wall) that prevents a complete perturbation
analysis. We show that, generically, (i) V_eff has precisely the form required
for regularization by the known S-deformation method, and (ii) a solution with
the regularized potential leads to regular scalar field and metric
perturbations of the initial configuration. The well-known conformal mappings
make these results also applicable to scalar-tensor and f(R) theories of
gravity. As a particular example, we prove the instability of all static
solutions with both normal and phantom scalars and V(\phi) = 0 under spherical
perturbations. We thus confirm the previous results on the unstable nature of
anti-Fisher wormholes and Fisher's singular solution and prove the instability
of other branches of these solutions including the anti-Fisher "cold black
holes".Comment: 18 pages, 5 figures. A few comments and references added. Final
version accepted at EPJ
Experiences Navigating the Pregnancy Care Continuum During the COVID-19 Pandemic
Introduction: The COVID-19 pandemic led to unprecedented changes in care delivery across the pregnancy care continuum. Our primary objective with this research was to characterize the range of ways that the early months of the COVID-19 pandemic affected pregnancy, childbirth, and postpartum care experiences. Methods: Pregnant and recently pregnant patients (n = 20) from obstetrics and gynecology clinical sites associated with Massachusetts General Hospital were interviewed about their experiences with prenatal care, childbirth, and postpartum care during the first wave of the COVID-19 pandemic. Interview transcripts were analyzed for emergent themes. Results: This sample included 20 pregnant and postpartum people, including 11 individuals who tested positive for COVID-19 during pregnancy or postpartum and nine with suspected infection. The ways in which COVID-19 or suspected COVID-19 affected experiences of prenatal care, childbirth, and postpartum care were complex and varied. Three themes were identified across narratives of pregnancy, birth, and postpartum care: patient perceptions of diminished access to care, stigma due to COVID-19 infection, and limited capacity of providers to honor patient preferences. Conclusions: A better understanding of pregnant and recently pregnant people's experiences during the early months of the COVID-19 pandemic can inform infection control policies and clinical care delivery practices that are more congruent with the needs and values of pregnant, birthing, and postpartum people as institutions craft responses to future pandemics. Approaches that maximize meaningful access across the pregnancy care continuum, center patients' priorities within adapted care models, and honor patient preferences as much as possible are important aspects of an appropriate response to future waves of COVID-19 and other pandemics
UK export performance research - review and implications
Previous research on export performance has been criticized for being a mosaic of autonomous endeavours and for a lack of theoretical development. Building upon extant models of export performance, and a review and analysis of research on export performance in the UK for the period 1990-2005, an integrated model of export performance is developed and theoretical explanations of export performance are put forward. It is suggested that a multi-theory approach to explaining export performance is viable. Management and policy implications for the UK emerging from the review and synthesis of the literature and the integrated model are discussed
Cytoplasmic âciliary inclusionsâ in isolation are not sufficient for the diagnosis of primary ciliary dyskinesia
Background: The diagnosis of primary ciliary dyskinesia (PCD) is difficult and requires a combination of clinical features, nasal nitric oxide testing, cilia ultrastructural analysis by electron microscopy (EM), and genetics. A recently described cytoplasmic ultrastructural change termed âciliary inclusionsâ was reported to be diagnostic of PCD; however, no supporting evidence of PCD was provided. In this study, we sought to confirm, or refute, the diagnosis of PCD in subjects with âciliary inclusionsâ on EM. Methods: Six subjects from five families with previous lab reports of âciliary inclusionsâ on EMs of ciliated cells were identified and evaluated at a Genetic Disorders of Mucociliary Clearance Consortium site. We performed a detailed clinical history, nasal nitric oxide measurement, genetic testing including whole-exome sequencing (WES), and when possible, repeat ciliary EM study. Results: Only one of six subjects had multiple and persistent clinical features congruent with PCD. No subject had situs inversus. Only one of six subjects had a very low nasal nitric oxide level. No âciliary inclusionsâ were found in three subjects who had a repeat ciliary EM, and ciliary axonemal ultrastructures were normal. Genetic testing, including WES, was negative for PCD-causing genes, and for pathogenic variants in gene pathways that might cause âciliary inclusions,â such as ciliary biogenesis. Conclusion: âCiliary Inclusionsâ, in isolation, are not sufficient to diagnosis PCD. If seen, additional studies should be done to pursue an accurate diagnosis
Measurement of the vector analyzing power in elastic electron-proton scattering as a probe of double photon exchange amplitudes
We report the first measurement of the vector analyzing power in inclusive
transversely polarized elastic electron-proton scattering at Q^2 = 0.1
(GeV/c)^2 and large scattering angles. This quantity should vanish in the
single virtual photon exchange, plane wave impulse approximation for this
reaction, and can therefore provide information on double photon exchange
amplitudes for electromagnetic interactions with hadronic systems. We find a
non-zero value of A=-15.4+/-5.4 ppm. No calculations of this observable for
nuclei other than spin 0 have been carried out in these kinematics, and the
calculation using the spin orbit interaction from a charged point nucleus of
spin 0 cannot describe these data.Comment: 4 pages, 2 figures, submitted to Phys. Rev. Let
Trisomy 21 activates the kynurenine pathway via increased dosage of interferon receptors
Altres ajuts: This work has also been supported by a "MaratĂł TV3" grant (20141210 to J.F. and 044412 to R.B.).Trisomy 21 (T21) causes Down syndrome (DS), affecting immune and neurological function by ill-defined mechanisms. Here we report a large metabolomics study of plasma and cerebrospinal fluid, showing in independent cohorts that people with DS produce elevated levels of kynurenine and quinolinic acid, two tryptophan catabolites with potent immunosuppressive and neurotoxic properties, respectively. Immune cells of people with DS overexpress IDO1, the rate-limiting enzyme in the kynurenine pathway (KP) and a known interferon (IFN)-stimulated gene. Furthermore, the levels of IFN-inducible cytokines positively correlate with KP dysregulation. Using metabolic tracing assays, we show that overexpression of IFN receptors encoded on chromosome 21 contribute to enhanced IFN stimulation, thereby causing IDO1 overexpression and kynurenine overproduction in cells with T21. Finally, a mouse model of DS carrying triplication of IFN receptors exhibits KP dysregulation. Together, our results reveal a mechanism by which T21 could drive immunosuppression and neurotoxicity in DS
Adding tree rings to North America's National Forest Inventories: an essential tool to guide drawdown of atmospheric CO2
Tree-ring time series provide long-term, annually resolved information on the growth of trees. When sampled in a systematic context, tree-ring data can be scaled to estimate the forest carbon capture and storage of landscapes, biomes, and-ultimately-the globe. A systematic effort to sample tree rings in national forest inventories would yield unprecedented temporal and spatial resolution of forest carbon dynamics and help resolve key scientific uncertainties, which we highlight in terms of evidence for forest greening (enhanced growth) versus browning (reduced growth, increased mortality). We describe jump-starting a tree-ring collection across the continent of North America, given the commitments of Canada, the United States, and Mexico to visit forest inventory plots, along with existing legacy collections. Failing to do so would be a missed opportunity to help chart an evidence-based path toward meeting national commitments to reduce net greenhouse gas emissions, urgently needed for climate stabilization and repair.Published versio
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