The slip history of the 1994 Northridge, California, earthquake determined from strong-motion, teleseismic, GPS, and leveling data

We present a rupture model of the Northridge earthquake, determined from the joint inversion of near-source strong ground motion recordings, P and SH teleseismic body waves, Global Positioning System (GPS) displacement vectors, and permanent uplift measured along leveling lines. The fault is defined to strike 122° and dip 40° to the south-southwest. The average rake vector is determined to be 101°, and average slip is 1.3 m; the peak slip reaches about 3 m. Our estimate of the seismic moment is 1.3 ± 0.2 × 10^(26) dyne-cm (potency of 0.4 km3). The rupture area is small relative to the overall aftershock dimensions and is approximately 15 km along strike, nearly 20 km in the dip direction, and there is no indication of slip shallower than about 5 to 6 km. The up-dip, strong-motion velocity waveforms are dominated by large S-wave pulses attributed to source directivity and are comprised of at least 2 to 3 distinct arrivals (a few seconds apart). Stations at southern azimuths indicate two main S-wave arrivals separated longer in time (about 4 to 5 sec). These observations are best modeled with a complex distribution of subevents: The initial S-wave arrival comes from an asperity that begins at the hypocenter and extends up-dip and to the north where a second, larger subevent is centered (about 12 km away). The secondary S arrivals at southern azimuths are best fit with additional energy radiation from another high slip region at a depth of 19 km, 8 km west of the hypocenter. The resolving power of the individual data sets is examined by predicting the geodetic (GPS and leveling) displacements with the dislocation model determined from the waveform data, and vice versa, and also by analyzing how well the teleseismic solution predicts the recorded strong motions. The general features of the geodetic displacements are not well predicted from the model determined independently from the strong-motion data; likewise, the slip model determined from geodetic data does not adequately reproduce the strong-motion characteristics. Whereas a particularly smooth slip pattern is sufficient to satisfy the geodetic data, the strong-motion and teleseismic data require a more heterogeneous slip distribution in order to reproduce the velocity amplitudes and frequency content. Although the teleseismic model can adequately reproduce the overall amplitude and frequency content of the strong-motion velocity recordings, it does a poor job of predicting the geodetic data. Consequently, a robust representation of the slip history and heterogeneity requires a combined analysis of these data sets

Racial differences in neurocognitive outcomes post-stroke: The impact of healthcare variables

AbstractObjectives:The present study examined differences in neurocognitive outcomes among non-Hispanic Black and White stroke survivors using the NIH Toolbox-Cognition Battery (NIHTB-CB), and investigated the roles of healthcare variables in explaining racial differences in neurocognitive outcomes post-stroke.Methods:One-hundred seventy adults (91 Black; 79 White), who participated in a multisite study were included (age:M=56.4;SD=12.6; education:M=13.7;SD=2.5; 50% male; years post-stroke: 1–18; stroke type: 72% ischemic, 28% hemorrhagic). Neurocognitive function was assessed with the NIHTB-CB, using demographically corrected norms. Participants completed measures of socio-demographic characteristics, health literacy, and healthcare use and access. Stroke severity was assessed with the Modified Rankin Scale.Results:An independent samplesttest indicated Blacks showed more neurocognitive impairment (NIHTB-CB Fluid Composite T-score:M=37.63;SD=11.67) than Whites (Fluid T-score:M=42.59,SD=11.54;p=.006). This difference remained significant after adjusting for reading level (NIHTB-CB Oral Reading), and when stratified by stroke severity. Blacks also scored lower on health literacy, reported differences in insurance type, and reported decreased confidence in the doctors treating them. Multivariable models adjusting for reading level and injury severity showed that health literacy and insurance type were statistically significant predictors of the Fluid cognitive composite (p&lt;.001 andp=.02, respectively) and significantly mediated racial differences on neurocognitive impairment.Conclusions:We replicated prior work showing that Blacks are at increased risk for poorer neurocognitive outcomes post-stroke than Whites. Health literacy and insurance type might be important modifiable factors influencing these differences. (JINS, 2017,23, 640–652)</jats:p

Are 3D virtual environments better than 2D interfaces in serious games performance? An explorative study for the assessment of executive functions

This is an Accepted Manuscript of an article published by Taylor & Francis in Applied Neuropsychology: Adult on 05/09/2019, available online: http://www.tandfonline.com/10.1080/23279095.2019.1607735[EN] Executive functions refer to higher-order cognitive processes that supervise and guide goaldirected and adaptive behaviors in response to everyday situations. The traditional measures used to assess executive functions include paper-and-pencil tests and/or computerized tests that have been found to have a moderate level of ecological validity in predicting real-world performance. Serious games (SG) represent a novel methodological approach, allowing investigating subjects¿ performance in real-simulated situations. Serious games are computer games whose primary purposes include investigating human behaviors and changes. Furthermore, SG can also vary according to the technology used and the interaction. Indeed, a SG can be rendered via a nonimmersive screen-based (2D) or via an immersive virtual reality game (3D). Starting from these premises, we compared a narrativecontextualized SG in 2D and 3D, correlating them with traditional tests. Findings showed different condition correlations with the traditional tasks and the comparison between the two systems have revealed that 3D is able to generate lower reaction times, higher correct answers, and lower perseverative responses in attentional abilities, inhibition control, and cognitive shifting than 2D condition. The present study yielded evidence on the use of more ecological tools to identify the functional cognitive status in real-simulated contexts along with traditional evaluation.This work was supported by the Spanish Ministry of Economy, Industry, and Competitiveness funded project Advanced Therapeutically Tools for Mental Health (DPI2016-77396-R).Chicchi-Giglioli, IA.; Juan-Ripoll, CD.; Parra Vargas, E.; Alcañiz Raya, ML. 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2019 Ridgecrest Earthquake Reveals Areas of Los Angeles That Amplify Shaking of High-Rises

The populace of Los Angeles, California, was startled by shaking from the M 7.1 earthquake that struck the city of Ridgecrest located 200 km to the north on 6 July 2019. Although the earthquake did not cause damage in Los Angeles, the experience in high‐rise buildings was frightening in contrast to the shaking felt in short buildings. Observations from 560 ground‐level accelerometers reveal large variations in shaking in the Los Angeles basin that occurred for more than 2 min. The observations come from the spatially dense Community Seismic Network (CSN), combined with the sparser Southern California Seismic Network and California Strong Motion Instrumentation Program networks. Site amplification factors for periods of 1, 3, 6, and 8 s are computed as the ratio of each station’s response spectral values combined for the two horizontal directions, relative to the average of three bedrock sites. Spatially coherent behavior in site amplification emerges for periods ≥3  s⁠, and the maximum calculated site amplifications are the largest, by factors of 7, 10, and 8, respectively, for 3, 6, and 8 s periods. The dense CSN observations show that the long‐period amplification is clearly, but only partially, correlated with the depth to basement. Sites with the largest amplifications for the long periods (⁠≥3  s⁠) are not close to the deepest portion of the basin. At 6 and 8 s periods, the maximum amplifications occur in the western part of the Los Angeles basin and in the south‐central San Fernando Valley sedimentary basin. The observations suggest that the excitation of a hypothetical high‐rise located in an area characterized by the largest site amplifications could be four times larger than in a downtown Los Angeles location

Computational models for inferring biochemical networks

Biochemical networks are of great practical importance. The interaction of biological compounds in cells has been enforced to a proper understanding by the numerous bioinformatics projects, which contributed to a vast amount of biological information. The construction of biochemical systems (systems of chemical reactions), which include both topology and kinetic constants of the chemical reactions, is NP-hard and is a well-studied system biology problem. In this paper, we propose a hybrid architecture, which combines genetic programming and simulated annealing in order to generate and optimize both the topology (the network) and the reaction rates of a biochemical system. Simulations and analysis of an artificial model and three real models (two models and the noisy version of one of them) show promising results for the proposed method.The Romanian National Authority for Scientific Research, CNDI–UEFISCDI, Project No. PN-II-PT-PCCA-2011-3.2-0917

Inhibition of mapk signalling promotes cell cycle arrest and sensitises intrahepatic cholangiocarcinoma cells to chemotherapy

Introduction: Intrahepatic cholangiocarcinoma (ICC) is the second most common primary hepatic malignancy, accounting for approximately 15% of cases of primary liver cancer. Although new treatments have increased survival for many other cancers, including the more common primary hepatocellular carcinoma, treatment strategies and survival for patients with ICC have seen little improvement. Our previous studies suggest that the mitogen-activated protein kinase (MAPK) signalling plays a central role in the regulation of cell proliferation in human ICC. However the molecular mechanisms are poorly understood. In this study, we aim to explore whether inhibition of the MAPK pathway and its downstream effectors enhances the sensitisation of ICC cells to the chemotherapeutic agent cisplatinum. Method: We used a combinatorial approach of immunohistochemical and gene expression analyses to investigate the expression of MAPK-related genes in ICC tumours. Furthermore, by using in-vitroand in-vivoanalyses we have characterised the function of a novel MAPK downstream effector in ICC cells. Results: The expression of MAPK signalling was determined by immunohistochemical staining in tumour samples from a cohort of 14 ICC patients. High expression of phospho-activated MAPK was observed in 71.4% (10/14) of ICC cases as compared with surrounding nontumour tissue. Likewise, expression of JDP, a downstream effector of the MAPK signalling, was scored as high intensity in 64.3% (9/14). Strikingly, elevated expression of JDP transcripts was also observed in two independent cohorts of human ICC (n = 149 and n = 109 per group, respectively) compared to surrounding normal liver tissue. Consistent with the in-vivo analyses of human samples, immunoblotting analyses showed constitutive activation of MAPK and expression of JDP in ICC-derived cells (i.e. SG231, CCLP-1 and HuCCT1). Using loss-of-function analyses, we demonstrates that knockdown of JDP in ICC-derived cells resulted in cell cycle arrest and reduced expression of cell cycle regulators (i.e. cyclins), and had minimal effect on apoptosis. Chemical inhibition of JDP significantly sensitises ICC-derived cells to cisplatinum (P < 0.001). Conclusion: These results demonstrate that enhanced activation of MAPK signalling is important for ICC cell proliferation and suggest that targeting its downstream effectors is a potential therapeutic strategy for ICC

Small ruminant lentivirus genetic subgroups associate with sheep TMEM154 genotypes.

Abstract: Small ruminant lentiviruses (SRLVs) are prevalent in North American sheep and a major cause of production losses for the U.S. sheep industry. Sheep susceptibility to SRLV infection is influenced by genetic variation within the ovine transmembrane 154 gene (TMEM154). Animals with either of two distinct TMEM154 haplotypes that both encode glutamate at position 35 of the protein (E35) are at greater risk of SRLV infection than those homozygous with a lysine (K35) haplotype. Prior to this study, it was unknown if TMEM154 associations with infection are influenced by SRLV genetic subgroups. Accordingly, our goals were to characterize SRLVs naturally infecting sheep from a diverse U.S. Midwestern flock and test them for associations with TMEM154 E35K genotypes. Two regions of the SRLV genome were targeted for proviral amplification, cloning, sequence analysis, and association testing with TMEM154 E35K genotypes: gag and the transmembrane region of env. Independent analyses of gag and env sequences showed that they clustered in two subgroups (1 and 2), they were distinct from SRLV subtypes originating from Europe, and that subgroup 1 associated with hemizygous and homozygous TMEM154 K35 genotypes and subgroup 2 with hemi- and homozygous E35 genotypes (gag p < 0.001, env p = 0.01). These results indicate that SRLVs in the U.S. have adapted to infect sheep with specific TMEM154 E35K genotypes. Consequently, both host and SRLV genotypes affect the relative risk of SRLV infection in sheep

Downtown Los Angeles 52-Story High-Rise and Free-Field Response to an Oil Refinery Explosion

The ExxonMobil Corp. oil refinery in Torrance, California experienced an explosion on February 18, 2015 causing ground shaking equivalent to a magnitude 2.0 earthquake. The impulse response for the source was computed from Southern California Seismic Network data for a single force system with a value of 2×10^5 kN vertically downward. The refinery explosion produced an air pressure wave that was recorded 22.8 km away in a 52-story high-rise building in downtown Los Angeles by a dense accelerometer array that is a component of the Community Seismic Network. The array recorded anomalous waveforms on each floor displaying coherent arrivals that are consistent with the building's elastic response to a pressure wave caused by the refinery explosion. Using a finite-element model of the building, the force on the building on a floor-by-floor scale was found to range up to 1.42 kN, corresponding to a pressure perturbation of 7.7 Pa