1,363 research outputs found
A HST study of the stellar populations in the cometary dwarf irregular galaxy NGC 2366
We present V and I photometry of the resolved stars in the cometary dwarf
irregular galaxy NGC 2366, using Wide Field Planetary Camera 2 images obtained
with the Hubble Space Telescope. The resulting color-magnitude diagram reaches
down to I~26.0 mag. It reveals not only a young population of blue
main-sequence stars (age <30 Myr) but also an intermediate-age population of
blue and red supergiants (20 Myr<age<100 Myr), and an older evolved populations
of asymptotic giant branch (AGB) stars (age >100 Myr) and red giant branch
(RGB) stars (age >1 Gyr). The measured magnitude I=23.65+/-0.10 mag of the RGB
tip results in a distance modulus m-M=27.67+/-0.10, which corresponds to a
distance of 3.42+/-0.15 Mpc, in agreement with previous distance
determinations. The youngest stars are associated with the bright complex of
HII regions NGC 2363=Mrk 71 in the southwest extremity of the galaxy. As a
consequence of the diffusion and relaxation processes of stellar ensembles, the
older the stellar population is, the smoother and more extended is its spatial
distribution. An underlying population of older stars is found throughout the
body of NGC 2366. The most notable feature of this older population is the
presence of numerous relatively bright AGB stars. The number ratio of AGB to
RGB stars and the average absolute brightness of AGB stars in NGC 2366 are
appreciably higher than in the BCD VII Zw 403, indicating a younger age of the
AGB stars in NGC 2366. In addition to the present burst of age <100 Myr, there
has been strong star formation activity in the past of NGC 2366, from ~100 Myr
to <3 Gyr ago.Comment: 32 pages, 15 figures, accepted for publication in the Astrophysical
Journa
Structure of the response regulator VicR DNA-binding domain
The structure of the DNA-binding domain of the response regulator VicR from E. faecalis has been solved at 1.9â
Ă
resolution. It is very similar to the related domains from PhoB and OmpR, but differs in two loops that may affect transcription activation or DNAâprotein interactions
On subgroups in division rings of type
Let be a division ring with center . We say that is a {\em
division ring of type } if for every two elements the division
subring is a finite dimensional vector space over . In this paper
we investigate multiplicative subgroups in such a ring.Comment: 10 pages, 0 figure
Prostate Cancer Disparities in Risk Group at Presentation and Access to Treatment for Asian Americans, Native Hawaiians, and Pacific Islanders: A Study With Disaggregated Ethnic Groups
PURPOSE: We identified (1) differences in localized prostate cancer (PCa) risk group at presentation and (2) disparities in access to initial treatment for Asian American, Native Hawaiian, and Pacific Islander (AANHPI) men with PCa after controlling for sociodemographic factors. METHODS: We assessed all patients in the National Cancer Database with localized PCa with low-, intermediate-, and high-risk disease who identified as Thai, White, Asian Indian, Chinese, Vietnamese, Korean, Japanese, Filipino, Hawaiian, Pacific Islander, Laotian, Pakistani, Kampuchean, and Hmong. Multivariable logistic regression defined adjusted odds ratios (AORs) with 95% CI of (1) presenting at progressively higher risk group and (2) receiving treatment or active surveillance with intermediate- or high-risk disease, adjusting for sociodemographic and clinical factors. RESULTS: Among 980,889 men (median age 66 years), all AANHPI subgroups with the exception of Thai (AOR = 0.84 [95% CI, 0.58 to 1.21], P > .05), Asian Indian (AOR = 1.12 [95% CI, 1.00 to 1.25], P > .05), and Pakistani (AOR = 1.34 [95% CI, 0.98 to 1.83], P > .05) men had greater odds of presenting at a progressively higher PCa risk group compared with White patients (Chinese AOR = 1.18 [95% CI, 1.11 to 1.25], P < .001; Japanese AOR = 1.36 [95% CI, 1.26 to 1.47], P < .001; Filipino AOR = 1.37 [95% CI, 1.29 to 1.46], P < .001; Korean AOR = 1.32 [95% CI, 1.18 to 1.48], P < .001; Vietnamese AOR = 1.20 [95% CI, 1.07 to 1.35], P = .002; Laotian AOR = 1.60 [95% CI, 1.08 to 2.36], P = .018; Hmong AOR = 4.07 [95% CI, 1.54 to 10.81], P = .005; Kampuchean AOR = 1.55 [95% CI, 1.03 to 2.34], P = .036; Asian Indian or Pakistani AOR = 1.15 [95% CI, 1.07 to 1.24], P < .001; Native Hawaiians AOR = 1.58 [95% CI, 1.38 to 1.80], P < .001; and Pacific Islanders AOR = 1.58 [95% CI, 1.37 to 1.82], P < .001). Additionally, Japanese Americans (AOR = 1.46 [95% CI, 1.09 to 1.97], P = .013) were more likely to receive treatment compared with White patients. CONCLUSION: Our findings suggest that there are differences in PCa risk group at presentation by race or ethnicity among Asian American, Native Hawaiian, and Pacific Islander subgroups and that there exist disparities in treatment patterns. Although AANHPI are often studied as a homogenous group, heterogeneity upon subgroup disaggregation underscores the importance of further study to assess and address barriers to PCa care
Recommended from our members
Impact of Th1 CD4 Follicular Helper T Cell Skewing on Antibody Responses to an HIV-1 Vaccine in Rhesus Macaques.
Generating durable humoral immunity through vaccination depends upon effective interactions of follicular helper T (Tfh) cells with germinal center (GC) B cells. Th1 polarization of Tfh cells is an important process shaping the success of Tfh-GC B cell interactions by influencing costimulatory and cytokine-dependent Tfh help to B cells. However, the question remains as to whether adjuvant-dependent modulation of Tfh cells enhances HIV-1 vaccine-induced antienvelope (anti-Env) antibody responses. We investigated whether an HIV-1 vaccine platform designed to increase the number of Th1-polarized Tfh cells enhances the magnitude and quality of anti-Env antibodies. Utilizing a novel interferon-induced protein 10 (IP-10)-adjuvanted HIV-1 DNA prime followed by a monophosphoryl lipid A and QS-21 (MPLA+QS-21)-adjuvanted Env protein boost (DIP-10 PALFQ) in macaques, we observed higher anti-Env serum IgG titers with greater cross-clade reactivity, specificity for V1V2, and effector functions than in macaques primed with DNA lacking IP-10 and boosted with MPLA-plus-alum-adjuvanted Env protein (DPALFA) The DIP-10 PALFQ vaccine regimen elicited higher anti-Env IgG1 and lower IgG4 antibody levels in serum, showing for the first time that adjuvants can dramatically impact the IgG subclass profile in macaques. The DIP-10 PALFQ regimen also increased vaginal and rectal IgA antibodies to a greater extent. Within lymph nodes, we observed augmented GC B cell responses and the promotion of Th1 gene expression profiles in GC Tfh cells. The frequency of GC Tfh cells correlated with both the magnitude and avidity of anti-Env serum IgG. Together, these data suggest that adjuvant-induced stimulation of Th1-Tfh cells is an effective strategy for enhancing the magnitude and quality of anti-Env antibody responses.IMPORTANCE The results of the RV144 trial demonstrated that vaccination could prevent HIV transmission in humans and that longevity of anti-Env antibodies may be key to this protection. Efforts to improve upon the prime-boost vaccine regimen used in RV144 have indicated that booster immunizations can increase serum anti-Env antibody titers but only transiently. Poor antibody durability hampers efforts to develop an effective HIV-1 vaccine. This study was designed to identify the specific elements involved in the immunological mechanism necessary to produce robust HIV-1-specific antibodies in rhesus macaques. By clearly defining immune-mediated pathways that improve the magnitude and functionality of the anti-HIV-1 antibody response, we will have the foundation necessary for the rational development of an HIV-1 vaccine
Ultrafast supercontinuum spectroscopy of carrier multiplication and biexcitonic effects in excited states of PbS quantum dots
We examine the multiple exciton population dynamics in PbS quantum dots by
ultrafast spectrally-resolved supercontinuum transient absorption (SC-TA). We
simultaneously probe the first three excitonic transitions over a broad
spectral range. Transient spectra show the presence of first order bleach of
absorption for the 1S_h-1S_e transition and second order bleach along with
photoinduced absorption band for 1P_h-1P_e transition. We also report evidence
of the one-photon forbidden 1S_{h,e}-1P_{h,e} transition. We examine signatures
of carrier multiplication (multiexcitons for the single absorbed photon) from
analysis of the first and second order bleaches, in the limit of low absorbed
photon numbers (~ 10^-2), at pump energies from two to four times the
semiconductor band gap. The multiexciton generation efficiency is discussed
both in terms of a broadband global fit and the ratio between early- to
long-time transient absorption signals.. Analysis of population dynamics shows
that the bleach peak due to the biexciton population is red-shifted respect the
single exciton one, indicating a positive binding energy.Comment: 16 pages, 5 figure
An imaging and spectroscopic study of the very metal-deficient blue compact dwarf galaxy Tol 1214--277
We present a spectrophotometric study based on VLT/FORS I observations of one
of the most metal-deficient blue compact dwarf (BCD) galaxies known, Tol
1214-277 (Z ~ Zsun/25). The data show that roughly half of the total luminosity
of the BCD originates from a bright and compact starburst region located at the
northeastern tip of a faint dwarf galaxy with cometary appearance. The
starburst has ignited less than 4 Myr ago and its emission is powered by
several thousands O7V stars and ~ 170 late-type nitrogen Wolf-Rayet stars
located within a compact region with < 500 pc in diameter. For the first time
in a BCD, a relatively strong [Fe V] 4227 emission line is seen which together
with intense He II 4686 emission indicates the presence of a very hard
radiation field in Tol 1214-277. We argue that this extraordinarily hard
radiation originates from both Wolf--Rayet stars and radiative shocks in the
starburst region. The structural properties of the low-surface-brightness (LSB)
component underlying the starburst have been investigated by means of surface
photometry down to 28 B mag/sq.arcsec. We find that, for a surface brightness
level fainter than ~ 24.5 B mag/sq.arcsec, an exponential fitting law provides
an adequate approximation to its radial intensity distribution. The broad-band
colors in the outskirts of the LSB component of Tol 1214-277 are nearly
constant and are consistent with an age below one Gyr. This conclusion is
supported by the comparison of the observed spectral energy distribution (SED)
of the LSB host with theoretical SEDs.Comment: 17 pages, 11 Postscript figures, uses emulateapj.sty, to appear in
Astronomical Journa
- âŠ