Pancancer analysis of DNA methylation-driven genes using MethylMix.

Aberrant DNA methylation is an important mechanism that contributes to oncogenesis. Yet, few algorithms exist that exploit this vast dataset to identify hypo- and hypermethylated genes in cancer. We developed a novel computational algorithm called MethylMix to identify differentially methylated genes that are also predictive of transcription. We apply MethylMix to 12 individual cancer sites, and additionally combine all cancer sites in a pancancer analysis. We discover pancancer hypo- and hypermethylated genes and identify novel methylation-driven subgroups with clinical implications. MethylMix analysis on combined cancer sites reveals 10 pancancer clusters reflecting new similarities across malignantly transformed tissues

Developing a national database on Librarianship and Information Science. The case of E-VIVA, the Hellenic fulltext database

The paper presents the Hellenic fulltext database on Librarianship and Information Science E-VIVA (Ellinike Vivliothikonomike Vase), developed by the Library of the University of Cyprus. The objectives of E-VIVA is to identify, gather, organize, digitize and promote the research, conducted in Greece and Cyprus in the scientific fields of Archival, Library and Infor-mation Sciences. Data are provided concerning the cov-erage, the content, the format and the environment of the database as well as the steps that have been fol-lowed for the development. The legal framework related with the copyright issues that are raised is also dis-cussed. Furthermore a comparison is attempted be-tween E-VIVA, eLIS, LISA and LISTA. Finally the next plans of the Library of the University of Cyprus for the project are presented

Bayesian Gene Set Analysis

Gene expression microarray technologies provide the simultaneous measurements of a large number of genes. Typical analyses of such data focus on the individual genes, but recent work has demonstrated that evaluating changes in expression across predefined sets of genes often increases statistical power and produces more robust results. We introduce a new methodology for identifying gene sets that are differentially expressed under varying experimental conditions. Our approach uses a hierarchical Bayesian framework where a hyperparameter measures the significance of each gene set. Using simulated data, we compare our proposed method to alternative approaches, such as Gene Set Enrichment Analysis (GSEA) and Gene Set Analysis (GSA). Our approach provides the best overall performance. We also discuss the application of our method to experimental data based on p53 mutation status

Alien Registration- Fowke, Sylvia K. (Auburn, Androscoggin County)

https://digitalmaine.com/alien_docs/31209/thumbnail.jp

Cardiovascular disease in free living wild animals with particular reference to the African elephant (Loxodonta africana)

A field survey to investigate the ecology of cardio-vascular disease in free living wild animals is described. Its aim was i) to assess the susceptibility of such animals to arteriosclerosis. and particularly to athero-sclerosis ii) to examine in greater detail the ecology of oardiovascular disease in a single, naturally-susceptible species in relation to dietary change and stress in naturally occurring situations. A total of 201 specimens, representing species of mammals and 25 of birds, was examined: 37 species of mammals had uncomplicated lipid deposits in the arterial intima, thought to represent a normal physiological occurrence; 13 had atheroma-like lesions of the intima; 20 species of birds shoved positive lipidosis. These findings. compared with those reported in taxonomioally equivalent groups of captive animals, are discussed. The African elephant was selected for special study. The eoology of its cardiovascular disease patterns was studied in three different habitat types: one natural (the 'control'). and two degenerate ('stressed'). Athero-sclerosis and medial sclerosis were found not to occur in the 'natural' habitat type, but to be directly correlated with habitat degeneration in the other two 'stressed ranges, where 'stress' factors included excessive exposure to sunlight, dietary changes, frustration of the migrator/ habit, disrupted calving patterns9 and over-population neither disease was found to be directly related to age, and each had a distinct intra-arterial development patterns the aetiology of each is therefore thought to be basically independent, although in advanced cases interaction may occur. Incidental results of the survey includes i) observations on the importance of relating the functional anatomy of the arterial supportive thickenings at ostia, bifurcation and regions of mechanical strain to the normal intra-aortic distribution of uncomplicated intimal lipid deposits; ii) observations on a valve-like structure in the aorta of the klipspringer; and iii) the formulation of a new field technique for assessing relative age in the African elephant.<p