Large-scale analysis of human alternative protein isoforms: pattern classification and correlation with subcellular localization signals

We investigated human alternative protein isoforms of >2600 genes based on full-length cDNA clones and SwissProt. We classified the isoforms and examined their co-occurrence for each gene. Further, we investigated potential relationships between these changes and differential subcellular localization. The two most abundant patterns were the one with different C-terminal regions and the one with an internal insertion, which together account for 43% of the total. Although changes of the N-terminal region are less common than those of the C-terminal region, extension of the C-terminal region is much less common than that of the N-terminal region, probably because of the difficulty of removing stop codons in one isoform. We also found that there are some frequently used combinations of co-occurrence in alternative isoforms. We interpret this as evidence that there is some structural relationship which produces a repertoire of isoformal patterns. Finally, many terminal changes are predicted to cause differential subcellular localization, especially in targeting either peroxisomes or mitochondria. Our study sheds new light on the enrichment of the human proteome through alternative splicing and related events. Our database of alternative protein isoforms is available through the internet

Space laser interferometers can determine the thermal history of the early Universe

It is shown that space-based gravitational wave detectors such as DECIGO and/or Big Bang Observer (BBO) will provide us with invaluable information on the cosmic thermal history after inflation and they will be able to determine the reheat temperature $T_R$ provided that it lies in the range preferred by the cosmological gravitino problem, $T_R\sim 10^{5-9}$ GeV. Therefore it is strongly desired that they will be put into practice as soon as possible.Comment: 5 page

Prevalence of early warning signs and symptoms of mental illness amongst males and females in Jos, Nigeria

Background: Mental illness is a psychological, emotional and mental health problems that affects the physical, behavioral and occupational functioning of an individual. The understand of the signs and symptoms of the disorder in a typical setting and by ordinary people or even among the literate is often difficulty; talk more of the early warning signs and symptoms of the illness. This is because some Africans still attribute the causes of mental illness to supernatural sources such as witchcraft, evil people, wicked people and demonic attacks etc. It thus becomes imperative to take a look at the general symptoms of mental illness.Objective of Study: The aim of the study was to determine the prevalence of early warning signs and symptoms of mental illness among males and females in Jos.Result: A total of 657 participants took part in the study. Participants were randomly selected. They comprised of 390 males who fell within the age range 17-65 with a Mean age of 29.09 and a standard deviation of 10.05 and 267 females who fell within he age range 16-60 with a Mean age of 31.28 and a standard deviation of 17.08. The study found out that that there was a significant difference in the prevalence of the early warning signs and symptoms of mental illness among the males and females (X2 = 10.5 >P.05 = 7.87). A higher proportion of females (75.41%) presented with the early warning signs and symptoms of mental illness.Conclusion: The result shows that a higher proportion of the sample (66.61 presented with the early warning signs and symptoms of mental illness by both males and females indicates that the society is sitting on a time bomb. This is because if these individuals are not checked and manage at this early stage, they can become fully blown victims of mental illness in later years. Thus mental health professionals and good policy should move quickly to prevent mental illness in the society.Keywords: Early warning Signs, Symptoms, Mental Illnes

Fibrations of genus two on complex surfaces

We consider fibrations of genus 2 over complex surfaces. The purpose of this paper is primarily to provide a geometric description of the possible structures of the fibration on a neighborhood of a singular fiber. In particular it is shown that the "geometric data" of the singular fiber determines the fibration on its neighborhood up to a transversely holomorphic $C^{\infty}$-diffeomorphism. The method employed is quite flexible and it applies to good extent to fibrations of arbitrary genus.Comment: This is the final version, June 201

Higher Order Corrections to the Primordial Gravitational Wave Spectrum and its Impact on Parameter Estimates for Inflation

We study the impact of the use of the power series expression for the primordial tensor spectrum on parameter estimation from future direct detection gravitational wave experiments. The spectrum approximated by the power series expansion may give large deviation from the true (fiducial) value when it is normalized at CMB scale because of the large separation between CMB and direct detection scales. We derive the coefficients of the higher order terms of the expansion up to the sixth order within the framework of the slow-roll approximation and investigate how well the inclusion of higher order terms improves the analytic prediction of the spectrum amplitude by comparing with numerical results. Using the power series expression, we consider future constraints on inflationary parameters expected from direct detection experiments of the inflationary gravitational wave background and show that the truncation of the higher order terms can lead to incorrect evaluation of the parameters. We present two example models; a quadratic chaotic inflation model and mixed inflaton and curvaton model with a quartic inflaton potential.Comment: 25 pages, 7 figures, revised version accepted by JCA

Stochastic backgrounds of gravitational waves from extragalactic sources

Astrophysical sources emit gravitational waves in a large variety of processes occurred since the beginning of star and galaxy formation. These waves permeate our high redshift Universe, and form a background which is the result of the superposition of different components, each associated to a specific astrophysical process. Each component has different spectral properties and features that it is important to investigate in view of a possible, future detection. In this contribution, we will review recent theoretical predictions for backgrounds produced by extragalactic sources and discuss their detectability with current and future gravitational wave observatories.Comment: 10 pages, 9 figures, proceedings of the GWDAW 10 Conference, submitted to Class. & Quantum Gra