Gauge parameter dependence in gauge theories (revised: subsection 2.3)

Dependence on the gauge parameters is an important issue in gauge theories: physical quantities have to be independent. Extending BRS transformations by variation of the gauge parameter into a Grassmann variable one can control gauge parameter dependence algebraically. As application we discuss the anomaly coefficient in the Slavnov-Taylor identity, $S$-matrix elements, the vector two-point-function and the coefficients of renormalization group and Callan-Symanzik equation.Comment: 6, MPI-PhT/94-34, BUTP-94/1

Supersymmetric Yang-Mills theories with local coupling: The supersymmetric gauge

Supersymmetric pure Yang-Mills theory is formulated with a local, i.e. space-time dependent, complex coupling in superspace. Super-Yang-Mills theories with local coupling have an anomaly, which has been first investigated in the Wess-Zumino gauge and there identified as an anomaly of supersymmetry. In a manifest supersymmetric formulation the anomaly appears in two other identities: The first one describes the non-renormalization of the topological term, the second relates the renormalization of the gauge coupling to the renormalization of the complex supercoupling. Only one of the two identities can be maintained in perturbation theory. We discuss the two versions and derive the respective beta function of the local supercoupling, which is non-holomorphic in the first version, but directly related to the coupling renormalization, and holomorphic in the second version, but has a non-trivial, i.e.anomalous, relation to the beta function of the gauge coupling.Comment: References correcte

The Expression and Localization of N-Myc Downstream-Regulated Gene 1 in Human Trophoblasts

The protein N-Myc downstream-regulated gene 1 (NDRG1) is implicated in the regulation of cell proliferation, differentiation, and cellular stress response. NDRG1 is expressed in primary human trophoblasts, where it promotes cell viability and resistance to hypoxic injury. The mechanism of action of NDRG1 remains unknown. To gain further insight into the intracellular action of NDRG1, we analyzed the expression pattern and cellular localization of endogenous NDRG1 and transfected Myc-tagged NDRG1 in human trophoblasts exposed to diverse injuries. In standard conditions, NDRG1 was diffusely expressed in the cytoplasm at a low level. Hypoxia or the hypoxia mimetic cobalt chloride, but not serum deprivation, ultraviolet (UV) light, or ionizing radiation, induced the expression of NDRG1 in human trophoblasts and the redistribution of NDRG1 into the nucleus and cytoplasmic membranes associated with the endoplasmic reticulum (ER) and microtubules. Mutation of the phosphopantetheine attachment site (PPAS) within NDRG1 abrogated this pattern of redistribution. Our results shed new light on the impact of cell injury on NDRG1 expression patterns, and suggest that the PPAS domain plays a key role in NDRG1's subcellular distribution. © 2013 Shi et al

Braided Tensor Products and the Covariance of Quantum Noncommutative Free Fields

We introduce the free quantum noncommutative fields as described by braided tensor products. The multiplication of such fields is decomposed into three operations, describing the multiplication in the algebra M of functions on noncommutative space-time, the product in the algebra H of deformed field oscillators, and the braiding by factor Psi_{M,H} between algebras M and H. For noncommutativity generated by the twist factor we shall employ the star-product realizations of the algebra M in terms of functions on standard Minkowski space. The covariance of single noncommutative quantum fields under deformed Poincare symmetries is described by the algebraic covariance conditions which are equivalent to the deformation of generalized Heisenberg equations on Poincare group manifold. We shall calculate the covariant braided field commutator, which for free quantum noncommutative fields provides the field quantization condition and is given by standard Pauli-Jordan function. For ilustration of our new scheme we present explicit calculations for the well-known case in the literature of canonically deformed free quantum fields.Comment: 19 pages, v.4, final versio

Cellular differentiation determines the expression of the hypoxia-inducible protein NDRG1 in pancreatic cancer

N-myc downstream-regulated gene-1 (NDRG1) is a recently described hypoxia-inducible protein that is upregulated in various human cancers. Pancreatic ductal adenocarcinoma, called pancreatic cancer, is a highly aggressive cancer that is characterised by its avascular structure, which results in a severe hypoxic environment. In this study, we investigated whether NDRG1 is upregulated in these tumours, thus providing a novel marker for malignant cells in the pancreas. By immunohistochemistry, we observed that NDRG1 was highly expressed in well-differentiated cells of pancreatic cancer, whereas the poorly differentiated tumour cells were negative. In addition, hyperplastic islets and ducts of nonquiescent pancreatic tissue were positive. To further explore its selective expression in tumours, two well-established pancreatic cancer cell lines of unequal differentiation status were exposed to 2% oxygen. NDRG1 mRNA and protein were upregulated by hypoxia in the moderately differentiated Capan-1 cells; however, its levels remained unchanged in the poorly differentiated Panc-1 cell line. Taken together, our data suggest that NDRG1 will not serve as a reliable marker of tumour cells in the pancreas, but may serve as a marker of differentiation. Furthermore, we present the novel finding that cellular differentiation may be an important factor that determines the hypoxia-induced regulation of NDRG1

Reduced fire severity offers near-term buffer to climate-driven declines in conifer resilience across the western United States

Increasing fire severity and warmer, drier postfire conditions are making forests in the western United States (West) vulnerable to ecological transformation. Yet, the relative importance of and interactions between these drivers of forest change remain unresolved, particularly over upcoming decades. Here, we assess how the interactive impacts of changing climate and wildfire activity influenced conifer regeneration after 334 wildfires, using a dataset of postfire conifer regeneration from 10,230 field plots. Our findings highlight declining regeneration capacity across the West over the past four decades for the eight dominant conifer species studied. Postfire regeneration is sensitive to high-severity fire, which limits seed availability, and postfire climate, which influences seedling establishment. In the near-term, projected differences in recruitment probability between low- and high-severity fire scenarios were larger than projected climate change impacts for most species, suggesting that reductions in fire severity, and resultant impacts on seed availability, could partially offset expected climate-driven declines in postfire regeneration. Across 40 to 42% of the study area, we project postfire conifer regeneration to be likely following low-severity but not high-severity fire under future climate scenarios (2031 to 2050). However, increasingly warm, dry climate conditions are projected to eventually outweigh the influence of fire severity and seed availability. The percent of the study area considered unlikely to experience conifer regeneration, regardless of fire severity, increased from 5% in 1981 to 2000 to 26 to 31% by mid-century, highlighting a limited time window over which management actions that reduce fire severity may effectively support postfire conifer regeneration. © 2023 the Author(s)

A High-Resolution View of Genome-Wide Pneumococcal Transformation

Transformation is an important mechanism of microbial evolution through which bacteria have been observed to rapidly adapt in response to clinical interventions; examples include facilitating vaccine evasion and the development of penicillin resistance in the major respiratory pathogen Streptococcus pneumoniae. To characterise the process in detail, the genomes of 124 S. pneumoniae isolates produced through in vitro transformation were sequenced and recombination events detected. Those recombinations importing the selected marker were independent of unselected events elsewhere in the genome, the positions of which were not significantly affected by local sequence similarity between donor and recipient or mismatch repair processes. However, both types of recombinations were sometimes mosaic, with multiple non-contiguous segments originating from the same molecule of donor DNA. The lengths of the unselected events were exponentially distributed with a mean of 2.3 kb, implying that recombinations are stochastically resolved with a fixed per base probability of 4.4×10−4 bp−1. This distribution of recombination sizes, coupled with an observed under representation of large insertions within transferred sequence, suggests transformation has the potential to reduce the size of bacterial genomes, and is unlikely to act as an efficient mechanism for the uptake of accessory genomic loci