ANTIOXIDANT AND ANTI CLASTOGENIC POTENTIAL OF PIPER LONGUM L.

Objective: Present study was aimed to evaluate the antioxidant and anti clastogenic potential of methanol extract of Piper longum L (MEPL). Methods: Chromatographic analysis was carried out using thermo GC-Trace Ultra Ver: 5.0 GC-MS. Antioxidant activities were assessed by DPPH free radical scavenging assay and reducing power assay. Based on the antioxidant activity, micronuclei formation in peripheral blood lymphocytes was analyzed. The protection afforded by Piper longum L. against the cytotoxicity of peripheral blood lymphocytes were confirmed by the micronucleus (MN) assay. Results: The GC-MS analysis provides different peaks determining the presence of eighteen phytochemical compounds with different therapeutic activities. The methanol extract at a concentration of 40 μg/ml showed the highest antioxidant activity by DPPH assay (68.42%) comparable to standard, ascorbic acid (73.68%). The reducing power observed was in the order of 40 μg/ml>20 μg/ml>10 μg/ml. MEPL treatment decreased the frequency of MN in a concentration dependent manner. Conclusion: A substantial amount of bioactive components are present in Piper longum L. A good correlation of the antioxidant capacity of the plant was established by different assay methodologies. MN test confirmed the anti clastogenic potential in peripheral blood lymphocytes. Keywords: Piper longum L., MEPL, GC-MS, DPPH, reducing power, Micronuclei

Effect of seaweed extract on rice (Oryza sativa var. ADT53) productivity and soil fertility in Cauvery delta zone of Tamil Nadu, India

The monocropping of rice in the Deltaic zone deteriorates soil health and crop productivity. Seaweeds are marine resources easily available at negligible cost and also rich in bioactive compounds. A field experiment was conducted at Cauvery Delta zone of Tamil Nadu during summer season2021 to evaluate the bio-efficacy of Seaweed extract on growth, yield, and soil properties of rice, Oryza sativa var. ADT53. The experiment was framed in RBD comprising of 12 treatments viz., soil application of Seaweed extract(SWE) @ 12.5kg/ha,25kg/ha, 37.5kg/ha , foliar spraying of SWE gel & liquid @ 0.5% twice at tillering and panicle initiation stages, a combination of soil application and foliar spray and fertilizer alone. Experimental findings revealed that the soil application of SWE  @ 12.5kg/ha along with a foliar spray of seaweed liquid recorded higher plant height (121.1cm),dry matter production (11390kg/ha),yield attributes viz., number of grains per panicle (166), panicle length (21.8 cm), thousand grain weight (14.7g), number of productive tillers per m2 (275), grain yield (5612 kg/ha)and straw yield (7829 kg/ha). However, The soil application of SWE @ 25kg/ha recorded higher soil available nutrients viz.,N(260 kg/ha);P(42kg/ha); K(170kg/ha);Ca(27.7meq/100g); Mg(5.5meq/100g);S(18.2mg/kg);Zn (1.17ppm); Fe (33.82ppm); Cu(1.61ppm);Mn(18.97ppm).The study will help sustain rice productivity and soil fertility in the deltaic zone of Tamil Nadu. The soil application of seaweed extract @ 12.5kg/ha along with foliar spraying (0.5% twice) could be a promising option in the rice ecosystem

Effects of Semecarpus anacardium L.f. ethanol extract on serum biochemical parameters and antioxidant activity of DAL induced mice

Semecarpus anacardium L.f. nuts is one of the best, versatile and most commonly used herbs as a household remedy, distributed in sub-Himalayan region, Tropical region, Bihar, Bengal, Orissa and central and south parts of India. In this work, the anticancer efficacy of ethanol extract of Semecarpus anacardium nuts (EESA) was tested in Swiss albino mice with induced Dalton's Ascites Lymphoma (DAL). Ethanol extract of S. anacardium nuts was given daily for 14 days at doses of 200 mg/kg and 400 mg/kg body weight, after 24 hrs of tumor inoculation. After receiving the final dose and fasting for 18 hrs, the mice were euthanized. Serum biochemical and antioxidant characteristics were measured to determine antitumor activity. 5-Fluoro Uracil, a typical medication, was employed as a positive control. In comparison to the control group, ethanol extract-treated mice restored biochemical and antioxidant parameters to near-normal levels. Biochemical and antioxidant parameters in the Dalton's Ascited Lymphoma (DAL) animal model treated with EESA exhibited similar effects as the positive control drug 5-fluorouracil. Overall, the active ingredients present in ethanol extract of Semecarpus anacardium nuts, modulate serum biochemical and antioxidant parameters and bring about anti-tumor activity against Dalton's Ascites Lymphoma (DAL) in mice

Exploring the Impact of Resveratrol on Gynecological Cancer: Insights and Perspectives

Gynecological cancers, a group of malignancies affecting the female reproductive system, are a significant cause of morbidity and mortality in women. Different types of gynecological cancers differ by distinct attributes, risk determinants, and therapeutic methodologies. So, depending on the type and stage of the cancer, a tailored combination of therapies is required for the treatment. However, it is shocking that the side effects of these therapeutic methods range from mild to severe. Hence, developing innovative therapeutic approaches to improve patient outcomes is imperative. Here's the juncture where the role of plant-derived compounds in curing gynecological cancers becomes evident. Various plant-derived compounds, including phytochemicals, polyphenols, alkaloids, and terpenoids for their cytotoxic, apoptotic, anti-angiogenic, and immunomodulatory properties, have been examined so far. Besides, certain phytocompounds can modulate hormonal-dependent gynecological cancers. Among the widely studied phytocompounds, RSV is the one that is extensively researched in vitro, in vivo and in-silico studies. In this context, this review article provides insights into the present-day knowledge about how RSV can potentially manage gynecological cancers. However, further research is needed to standardize their mode of action, optimal dosages, and potential interactions with conventional treatments. Rigorous clinical trials must validate their safety and efficacy profiles in different patient populations. As a result, a novel avenue for treating and preventing gynecological cancers could emerge by harnessing the multifaceted properties of phyto compounds, instilling new hope for patients and healthcare providers alike

Effect of long term fertilization on phosphorus dynamics in root zone environment under finger millet - Maize cropping sequence

In an agro-ecosystem, phosphorus (P) is found in organic and an inorganic form which includes soluble P, sorbed P and mineral bounded P. In soil, added P sources undergo various soil processes like mineralization, immobilization, precipitation, weathering, dissolution, sorption and desorption. For understanding the P dynamics in clay loam (Vertic Ustropept) soil, the present study was undertaken in P dynamics under rhizosphere and non-rhizosphere environment of maize in Long Term Fertilizer Experiment at Tamil Nadu Agricultural University, Coimbatore. The results revealed that the fractions of various pools of inorganic NaOH extractable Fe - P, H2SO4 extractable Ca- P, NH4F extractable Al- P, NH4Cl extractable Saloid P and Na citrate - Dithionate extractable Reductant soluble P were dominant in the non-rhizospheric soil than rhizospheric environment. The order of inorganic P fractions in the non-rhizospheric and rhizospheric region of the soil was found as Ca-P > Fe-P > Al-P > Reductant soluble-P > Saloid P and the knee-high stage of the non - rhizosphere soil recorded the highest inorganic as well organic P fractions. Irrespective of P fractions, Ca – P was recorded high (192.5 &  186.7 mg kg-1 ) followed by Fe - P (40.8& 34.9 mg kg-1) at a knee-high stage in non-rhizosphere and rhizosphere, respectively. Practising various nutrient management systems, application of 100% recommended dose of fertilizer along with FYM @ 10 t ha-1 (T8) recorded significant changes in all inorganic (Ca-P, Fe-P, Al-P, Reductant soluble-P, Saloid P), organic fractions and also Total P followed by 150% NPK (T3) in sandy clay loam soil. Nowadays, increasing demand for P fertilizer in India, judicious use of P fertilizer is important. Despite that, intensively cultivated soils have a lot of P reserves like organic and inorganic P pools and effective way of P transformation management could reduce the quantum of P fertilization in soil

Effect of bio-seed priming and nano zinc oxide foliar application on quality and productivity of finger millet + greengram intercropping system

A critical stage of the plant's life cycle is germination and insufficient seedling emergence contributes to the lower productivity of finger millet. Priming improves seedling emergence, reduces stand establishment time, and improves seedling germination. There is a need to develop a new technology like Nanotechnology that can precisely detect and deliver the right amount of nutrients or other inputs to safe crops for the environment and maximising productivity. A field experiment was conducted during Kharif season to evaluate the response of effective farming practice for sole finger millet + greengram intercropping system under rainfed conditions to varied levels of bio-seed priming and foliar application of nanoparticles on crop growth and productivity. The results of the experiment revealed that finger millet (Eleusine coracana) intercropped with greengram (Vigna radiata) (2:1) had a significant level (<0.05) increase in growth and yield parameter of finger millet compared to sole finger millet. Application of Prosopis juliflora leaf extract 1 per cent alone + Foliar ZnO nanoparticle @ 500 ppm showed a significant level (<0.05) increase in growth and yield parameter like grain yield (3238.84 kg ha-1), finger millet equivalent yield (FMEY) (3483.84 kg ha-1) and straw yield (7393.83 kg ha-1) compared to Pogamia pinnata leaf extract 1% alone + Foliar ZnO nanoparticle @ 500 ppm. The present study mainly focussed on cropping system, bio seed priming, and foliar application of nano zinc oxide utilized during rainfed conditions to increase uniform germination, drought resistance and improve crop yield along with nutrient content in seeds

Effect of organic and inorganic nutrients on rice (Oryza sativa var. CO 51) productivity and soil fertility in the Western zone of Tamil Nadu, India

In sustainable agriculture, to ensure high-quality food production, a combination of organic and inorganic nutrient sources are required. During the winter season of 2020, a field experiment was undertaken in the western zone of Tamil Nadu to assess the effects of organics and inorganics on the growth, yield, and soil properties of rice, Oryza sativa var. CO 51. The experiment was framed in Random Block Design (RBD) comprising of 8 treatments viz., Recommended dose of fertilizer Soil Test Crop Response (STCR) approach (T1), RDF 75 % + Farm yard manure @ 12.5 t ha-1 (T2), T2 + Seed treatment with Azospirillum and Phosphobacteria + Soil application of AM fungi (T3), RDF 75 % + Vermicompost @ 5 t ha-1 (T4), T4 + Seed treatment with Azospirillum and Phosphobacteria + Soil application of AM fungi (T5), FYM @ 12.5 t ha-1 + Seed treatment with Azospirillum and Phosphobacteria + Soil application of AM fungi (T6), Vermicompost @ 5 t ha-1+ Seed treatment with Azospirillum and Phosphobacteria + Soil application of AM fungi (T7) and absolute control (T8) , replicated thrice. Among the integrated nutrient management practices, T5 proved its superiority over other treatments with respect to growth and physiological parameters followed by T3. This would have been because of the solubilization of phosphorus in the soil by AM organisms which is made accessible for crop growth. Utilization of biofertilizer enhanced the N availability and solubilized the inaccessible phosphorus, which thus recorded higher N accessibility and better phosphorus uptake when applied along with a recommended dose of fertilizer for rice.

Analysing the Resourcefulness of the Paragraph for Precedence Retrieval

Developing methods for extracting relevant legal information to aid legal practitioners is an active research area. In this regard, research efforts are being made by leveraging different kinds of information, such as meta-data, citations, keywords, sentences, paragraphs, etc. Similar to any text document, legal documents are composed of paragraphs. In this paper, we have analyzed the resourcefulness of paragraph-level information in capturing similarity among judgments for improving the performance of precedence retrieval. We found that the paragraph-level methods could capture the similarity among the judgments with only a few paragraph interactions and exhibit more discriminating power over the baseline document-level method. Moreover, the comparison results on two benchmark datasets for the precedence retrieval on the Indian supreme court judgments task show that the paragraph-level methods exhibit comparable performance with the state-of-the-art methodsComment: 5 pages , 3 figures, ICAIL 202

Insights into the Recent Advances in Nanomaterial Based Electrochemical Sensors for Pesticides in Food

Food safety is one of the rising concerns challenging all over the world and the analysis and determination of food contaminants to ensure the quality of food is highly inevitable. Electroanalytical sensors are a versatile tool for the accurate monitoring of food samples from the pollutants. Pesticides are one of the major sources of food pollutants and their impacts on human health is also very dangerous. This will trigger the researchers to develop more and more sensitive devices to monitor the level of various pesticides in various food samples, especially in agricultural products. Electrochemical sensors fabricated using nanocomposites offers more sensitive electrochemical response in the detection of these pesticides than traditional unmodified electrodes. This prompted us to write a mini review on the electrochemical sensors for pesticides in food using nanomaterials as modifiers from some of the previous reports. This review will motivate the experts working in this area to develop highly efficient sensing devices for pesticides, beneficial to the society as well