Intrusion features of a high-speed striker of a porous tungsten-based alloy with a strengthening filler in a steel barrier

The complex problem of increasing the penetrating power of strikers based on highly porous tungsten composites is considered by improving their strengthening properties by alloying the hardening components under high-speed collision conditions. Using the method of liquid-phase sintering, we fabricated samples of strikers based on a porous WNiFeCo alloy (tungsten + nickel + iron + cobalt), alloyed with tungsten carbide with cobalt (WCCo8) and titanium-tungsten carbide (TiWC). Dynamic tests of the strikers from the developed alloys were carried out at the collision velocity with a steel barrier of the order of 2800 m/s. The penetration depth of the striker based on a porous WNiFeCo alloy doped with tungsten carbides is 30% higher than the penetration depth of a striker of a monolithic WNiFe-90 alloy (tungsten + nickel + iron with a tungsten content of 90%)

Место аллогенной трансплантации гемопоэтических стволовых клеток в первой полной ремиссии при Ph-позитивном остром лимфобластном лейкозе у взрослых

Introduction. Ph-positive acute lymphoblastic leukemia (ALL) is a high risk group of B-lineage acute lymphoblastic leukemia (B-ALL). Since tyrosine kinase inhibitors (TKIs) were introduced, controversial data have been obtained on the efficacy of allogeneic hematopoietic stem cell (allo-HSCT) in the first complete remission.The objective was to evaluate the efficacy of allo-HSCT in the first complete remission of Ph-positive ALL in adult patients after remission induction with continuous chemotherapeutic exposure in combination with TKIs.Methods and materials. The retrospective analysis included 74 patients with a median age of 32 years (range 18–59) after allo-HSCT in the first complete remission and 58 patients with a median age of 39 years (range 18–65) in the first complete remission after conservative therapy. Ninety-one per cent and 83 % of patients received imatinib as TKIs in remission induction in the allo-HSCT and conservative therapy groups, respectively. The median time from the first complete remission to allo-HSCT was 7 months (range 2–33). Thirty-six patients (49 %) had positive minimal residual disease (MRD) status prior to allo-HSCT. Eighteen patients (14 %) over 40 years underwent allo-HSCT in the first complete remission.Results. Allo-HSCT improves overall survival (OS) and relapse-free survival (RFS) and by 9 months since the achievement of the first complete remission, they were 70.1 (95 % CI 56.4–88.6) in the allo-HSCT group versus 45.1 (95 % CI 33.4–61.0) in the conservative group, p=0.025 and 63.3 % (95 % CI 47.6–84.1) in the allo-HSCT group versus 44.8 % (95 % CI 33.2–60.4) in the conservative therapy group, p=0.04, respectively. Allo-HSCT in patients over 40 years does not improve 5-year OS and RFS and were 57.2 % (95 % CI 30.0–84.4) versus 59.8 % (95 % CI 36.9– 82.7), p=0.69, and 42.6 % (95 % CI 14.0–71.2) vs. 50.9 % (95 % CI 29.5–72.3), p=0, 88, respectively.Conclusion. Allo-HSCT performed before 9 months from achievement of the first complete remission after induction with imatinib is the preferred method of remission consolidation in patients from 18 to 40 years old. The optimal therapy for patients older than 40 years in the first complete remission is a conservative approach in combination with TKIs.Введение. Ph-позитивный ОЛЛ представляет собой группу высокого риска В-клеточного острого лимфобластного лейкоза (ОЛЛ). С внедрением ингибиторов тирозинкиназ (ИТК) получены противоречивые данные об эффективности алло-ТГСК в первой полной ремиссии заболевания.Цель. Оценить эффективность алло-ТГСК в первой полной ремиссии Ph-позитивного ОЛЛ у взрослых пациентов после индукции ремиссии с применением непрерывного химиотерпевтического воздействия в комбинации с ИТК первого поколения.Методы и материалы. В ретроспективный анализ включены 74 пациента с медианой возраста 32 года (диапазон 18–59) после алло-ТГСК в первой полной ремиссии и 58 пациентов с медианой возраста 39 лет (диапазон 18–65), достигших  первой  полной  ремиссии  после  консервативной  терапии.  91  %  и  83  %  пациентов  получали  иматиниб в качестве ИТК в индукции ремиссии в группах алло-ТГСК и консервативной терапии соответственно. Медиана времени выполнения алло-ТГСК составила 7 месяцев (диапазон 2–33). 36 пациентов (49 %) имели положительный статус минимальной остаточной болезни до алло-ТГСК. 18 пациентам (14 %) после 40 лет выполнена алло-ТГСК в первой полной ремиссии.Результаты. Выполнение алло-ТГСК приводит к улучшению результатов общей выживаемости (ОВ) и безрецидивной выживаемости (БРВ), которые на 9 месяцев от достижения первой полной ремиссии составляют 70,1 (95 % ДИ 56,4–88,6) в группе алло-ТГСК против 45,1 (95 % ДИ 33,4–61,0) в консервативной группе, р=0,025 и 63,3 % (95 % ДИ 47,6–84,1) в группе алло-ТГСК против 44,8 % (95 % ДИ 33,2–60,4) в группе консервативной терапии, р=0,04 соответственно. Выполнение алло-ТГСК в группе пациентов после 40 лет не способствует улучшению 5-летней ОВ и БРВ и составляет 57,2 % (95 % ДИ 30,0–84,4) против 59,8 % (95 % ДИ 36,9–82,7), р=0,69 и 42,6 % (95 % ДИ 14,0–71,2) против 50,9 % (95 % ДИ 29,5–72,3), р=0,88 соответственно.Выводы. Алло-ТГСК, выполненная до 9 месяцев от достижения первой полной ремиссии после индукции с включением иматиниба, является предпочтительным методом консолидации ремиссии в группе пациентов с 18 до 40 лет. Для пациентов старше 40 лет в первой полной ремиссии оптимальной терапией является консервативный подход в комбинации с ИТК

On the Issue of Distinguishing Individual and Group Training Activities in the Context of the Spread of the New Coronavirus Infection COVID-19

The subject of the article is the issue of distinguishing individual and group training activities, the importance of which has increased in the context of the spread of the new coronavirus infection COVID-19. The authors consider the existing legal regulation in the field of organizing and conducting training events, as well as issues that arise in practice. Proposals are put forward to eliminate the existing “gaps” in the legislation

Efficiency of various ways of processing of ground under cultures of the crop rotation

In work the analysis of a contamination of crops by weeds depending on receptions of the basic processing ground, their influence on development of cultural plants, distribution among crops and productivity of grain crops is resulted. It is established, that the combined systems of processing of the ground, based on a combination on years of usual plowing and superficial (disk) processings do not reduce productivity of cultures

Intrusion features of a high-speed striker of a porous tungsten-based alloy with a strengthening filler in a steel barrier

The complex problem of increasing the penetrating power of strikers based on highly porous tungsten composites is considered by improving their strengthening properties by alloying the hardening components under high-speed collision conditions. Using the method of liquid-phase sintering, we fabricated samples of strikers based on a porous WNiFeCo alloy (tungsten + nickel + iron + cobalt), alloyed with tungsten carbide with cobalt (WCCo8) and titanium-tungsten carbide (TiWC). Dynamic tests of the strikers from the developed alloys were carried out at the collision velocity with a steel barrier of the order of 2800 m/s. The penetration depth of the striker based on a porous WNiFeCo alloy doped with tungsten carbides is 30% higher than the penetration depth of a striker of a monolithic WNiFe-90 alloy (tungsten + nickel + iron with a tungsten content of 90%)