Development of Vaccines to Meet Public Health Needs: Incentives and Obstacles

Dr. Russell explains how such matters as high \u27costs of regulation, lack of an effective plan for delivery (particularly abroad) and politics can interfere with providing globally needed vaccines

Do changes in drinking motives mediate the relation between personality change and maturing out of problem drinking?

Recent research has indicated that developmental changes in the personality traits of neuroticism and impulsivity correlate with changes in problem drinking during emerging and young adulthood. However, it remains unclear what potential mechanisms, or mediators, could account for these associations. Drinking motives, particularly drinking to regulate negative affect (drinking to cope) and to get “high” or “drunk” (drinking for enhancement) have been posited to mediate the relationship between personality and drinking problems. Recent work indicates changes in drinking motives parallel changes in alcohol involvement from adolescence to young adulthood. The current study examined changes in drinking motives (i.e., coping and enhancement) as potential mediators of the relation between changes in personality (impulsivity and neuroticism) with changes in alcohol problems in emerging and young adulthood. Analyses were based on data collected from a cohort of college students (N=489) at varying risk for AUDs from ages 18–35. Parallel process latent growth modeling indicated that change in coping (but not enhancement) motives specifically mediated the relation between changes in neuroticism and alcohol problems as well as the relation between changes in impulsivity and alcohol problems. Findings suggest that change in coping motives is an important mechanism in the relation between personality change and the “maturing out” of problematic alcohol involvement

Design of doubly-complementary IIR digital filters using a single complex allpass filter, with multirate applications

It is shown that a large class of real-coefficient doubly-complementary IIR transfer function pairs can be implemented by means of a single complex allpass filter. For a real input sequence, the real part of the output sequence corresponds to the output of one of the transfer functions G(z) (for example, lowpass), whereas the imaginary part of the output sequence corresponds to its "complementary" filter H(z)(for example, highpass). The resulting implementation is structurally lossless, and hence the implementations of G(z) and H(z) have very low passband sensitivity. Numerical design examples are included, and a typical numerical example shows that the new implementation with 4 bits per multiplier is considerably better than a direct form implementation with 9 bits per multiplier. Multirate filter bank applications (quadrature mirror filtering) are outlined

Cotton Farmers' Technical Efficiency: Stochastic and Nonstochastic Production Function Approaches

Technical efficiency for cotton growers is examined using both stochastic (SFA) and nonstochastic (DEA) production function approaches. The empirical application uses farm-level data from four counties in west Texas. While efficiency scores for the individual farms differed between SFA and DEA, the mean efficiency scores are invariant of the method of estimation under the assumption of constant returns to scale. On average, irrigated farms are 80% and nonirrigated farms are 70% efficient. Findings show that in Texas, the irrigated farms, on average, could reduce their expenditures on other inputs by 10%, and the nonirrigated farms could reduce their expenditures on machinery and labor by 12% and 13%, respectively, while producing the same level of output.Crop Production/Industries, Productivity Analysis,

Efficient Refuge policies for Bt cotton in India

This study examined the efficient refuge policies for Bt cotton for three cotton growing regions in India. This was accomplished by developing a single-pest, dual-toxin biological model simulating bollworm resistance to the Bt toxin and synthetic pyrethroids, followed by formulating profit functions for Bt and non-Bt cotton for a representative producer in each region. Profits received in subsequent periods were considered in the regulatory model in order to choose a refuge constraint (static problem) or a sequence of refuge policies (dynamic problem) for each region that maximize discounted profits received over 15 years, subject to various economic and biological constraints. Dynamic solutions for the regulatory problem were derived for each region using the Bellman equation. Results suggested that South Indian farmers do not need to grow a refuge, but farmers in the North and Central regions do. Results also suggested that planting sprayed refugia might be more profitable than planting unsprayed refugia. Sensitivity analysis revealed that the refuge requirements were sensitive to the initial Bt resistance level, relative proportion of CBWs in natural refuges, and proportions of heterozygous and homozygous fitnesses in all of the three regions. Moreover, static refugia were found more profitable as compared to dynamic refugia in the North and Central regions.Food Security and Poverty,

Tree-structured complementary filter banks using all-pass sections

Tree-structured complementary filter banks are developed with transfer functions that are simultaneously all-pass complementary and power complementary. Using a formulation based on unitary transforms and all-pass functions, we obtain analysis and synthesis filter banks which are related through a transposition operation, such that the cascade of analysis and synthesis filter banks achieves an all-pass function. The simplest structure is obtained using a Hadamard transform, which is shown to correspond to a binary tree structure. Tree structures can be generated for a variety of other unitary transforms as well. In addition, given a tree-structured filter bank where the number of bands is a power of two, simple methods are developed to generate complementary filter banks with an arbitrary number of channels, which retain the transpose relationship between analysis and synthesis banks, and allow for any combination of bandwidths. The structural properties of the filter banks are illustrated with design examples, and multirate applications are outlined

A QUALITATIVE CHOICE ANALYSIS OF FACTORS INFLUENCING POST-CRP LAND USE DECISIONS

The future use of Conservation Reserve Program (CRP) lands is an important agricultural policy issue. To examine the effects of factors that influence landowners' post-contract use of CRP lands, a survey of Texas High Plains CRP contract holders was conducted in 1992. This study analyzes the results of the survey using a qualitative choice model. It was found that the presence of a livestock enterprise in the current contract holder's operation increases the probability of these acres remaining in the established cover. Contract holders who value the commodity base have an increased probability of returning their acres to crop production.Agricultural policy, Conservation Reserve Program, Ordered probit model, Land Economics/Use,

Solvation vs. freezing in a heteropolymer globule

We address the response of a random heteropolymer to preferential solvation of certain monomer types at the globule-solvent interface. For each set of monomers that can comprise the molecule's surface, we represent the ensemble of allowed configurations by a Gaussian distribution of energy levels, whose mean and variance depend on the set's composition. Within such a random energy model, mean surface composition is proportional to solvation strength under most conditions. The breadth of this linear response regime arises from approximate statistical independence of surface and volume energies. For a diverse set of monomer types, the excess of solvophilic monomers at the surface is large only for very strong solvent preference, even in the ground state.Comment: 10 pages, 1 figur