5,317 research outputs found
Duality Violation and the K --> pi pi Electroweak Penguin Operator Matrix Elements from Hadronic Tau Decays
We discuss a preliminary study of the impact of duality violations on
extractions from tau decay data of the D=6 VEVs which determine chiral limit
Standard Model K-->pi pi matrix elements of the electroweak penguin operators.Comment: 4 pages, 5 figures, prepared for the Proceedings of the 11th Particle
and Nuclear Intersections Conference (PANIC 2011), Boston, USA, July 24-29,
201
Non--decoupling, triviality and the parameter
The dependence of the parameter on the mass of the Higgs scalar and
the top quark is computed non--perturbatively using the expansion in
the standard model. We find an explicit expression for the parameter
that requires the presence of a physical cutoff. This should come as no
surprise since the theory is presumably trivial. By taking this cutoff into
account, we find that the parameter can take values only within a
limited range and has finite ambiguities that are suppressed by inverse powers
of the cutoff scale, the so called ``scaling--violations". We find that large
deviations from the perturbative results are possible, but only when the cutoff
effects are also large.Comment: 16pp, Figures NOT included, harvmac, minor modifications incl.
wording, refs., UCLA/92/TEP/23,OHSTPY-HEP-T-92-00
Therapeutic potential of targeting interleukin-1 family cytokines in chronic inflammatory skin diseases*
The interleukin (IL)-1 family of cytokines is a central regulator of a myriad of immunological responses. It comprises several cytokines, including those belonging to the IL-1, IL-36 and IL-18 subfamilies, as well as IL-33. The IL-1 family primarily plays a role in orchestrating innate immune responses, but is also involved in adaptive immunity. Increased interest in the IL-1 family occurred following the discovery that dysregulation of IL-1 signalling underlies the pathogenesis of several monogenic autoinflammatory diseases, characterized by sterile inflammation involving the skin and other organs. This also provided increased understanding of the role of innate immunity and the IL-1 family in polygenic autoinflammatory skin conditions, such as neutrophilic dermatoses, as well as in some of the most common chronic inflammatory skin diseases, such as psoriasis and hidradenitis suppurativa. Several therapeutic agents have been developed to inhibit the IL-1 family members and their signalling pathways. These have shown therapeutic efficacy in several chronic inflammatory skin disorders. The aim of this review is to thoroughly describe the consequences of pathological dysregulation of the IL-1, IL-33, IL-36 and IL-18 pathways in dermatological conditions and to provide a forward-looking update on therapeutic strategies targeting signalling by IL-1 family cytokines
Overview of Atopic Dermatitis in Different Ethnic Groups
Atopic dermatitis (AD) is a common chronic inflammatory skin disease with a high prevalence worldwide, including countries from Asia, Africa, and Latin America, and in different ethnic groups. In recent years, more attention has been placed on the heterogeneity of AD associated with multiple factors, including a patient’s ethnic background, resulting in an increasing body of clinical, genetic, epidemiologic, and immune-phenotypic evidence that delineates differences in AD among racial groups. Filaggrin (FLG) mutations, the strongest genetic risk factor for the development of AD, are detected in up to 50% of European and 27% of Asian AD patients, but very rarely in Africans. Th2 hyperactivation is a common attribute of all ethnic groups, though the Asian endotype of AD is also characterized by an increased Th17-mediated signal, whereas African Americans show a strong Th2/Th22 signature and an absence of Th1/Th17 skewing. In addition, the ethnic heterogeneity of AD may hold important therapeutic implications as a patient’s genetic predisposition may affect treatment response and, thereby, a tailored strategy that better targets the dominant immunologic pathways in each ethnic subgroup may be envisaged. Nevertheless, white patients with AD represent the largest ethnicity enrolled and tested in clinical trials and the most treated in a real-world setting, limiting investigations about safety and efficacy across different ethnicities. The purpose of this review is to describe the heterogeneity in the pathophysiology of AD across ethnicities and its potential therapeutic implications
Novel Therapeutic Strategies in the Topical Treatment of Atopic Dermatitis
Topical agents that are currently available for the treatment of atopic dermatitis may represent a valid approach in the management of mild or mild–moderate cases, whereas they are often supplemented with systemic therapies for handling more complex or unresponsive cases. The most used compounds include topical corticosteroids and calcineurin inhibitors, although their use might be burdened by side effects, poor response, and low patient compliance. Consequently, new innovative drugs with higher efficacy and safety both in the short and long term need to be integrated into clinical practice. A deeper understanding of the complex pathogenesis of the disease has led to identifying new therapeutic targets and to the development of innovative therapeutics. This narrative review aims to collect data on selected promising topical drugs that are in an advanced stage of development
Investigational systemic drugs for moderate to severe plaque psoriasis: What’s new?
Introduction: The therapeutic armamentarium for the treatment of psoriasis, a chronic inflammatory skin disease, is now reasonably broad and structured, with several therapeutic agents that demonstrated a successful long-term control of this condition. However, there are still unfulfilled gaps resulting from the inherent limitations of existing therapies, which have paved the way for the identification of new therapeutic strategies or the improvement of the existing ones. Areas covered: The aim of this review is to thoroughly explore new therapeutic strategies and novel drugs that are currently in the pipeline for the treatment of psoriasis, focusing primarily on agents that are currently in phase I/II of clinical development. Some of which retrace already existing therapeutic approaches, such as the IL23/Th17 pathway inhibition, while others unveil new and yet unexplored ones. Expert opinion: Since the therapeutic landscape of psoriasis is wide, it is not yet clear whether novel agents will fill the remaining gaps in the context of a broader and more diversified set of oral and biologic therapies. Nevertheless, with the development of precision medicine approaches, the development of innovative targeted drugs will still have a therapeutic rationale in psoriasis
alpha_s from tau decays revisited
Being a determination at low energies, the analysis of hadronic tau decay
data provides a rather precise determination of the strong coupling alpha_s
after evolving the result to M_Z. At such a level of precision, even small
non-perturbative effects become relevant for the central value and error. While
those effects had been taken into account in the framework of the operator
product expansion, contributions going beyond it, so-called duality violations,
have previously been neglected. The following investigation fills this gap
through a finite-energy sum rule analysis of tau decay spectra from the OPAL
experiment, including duality violations and performing a consistent fit of all
appearing QCD parameters. The resulting values for alpha_s(M_tau) are 0.307(19)
in fixed-order perturbation theory and 0.322(26) in contour-improved
perturbation theory, which translates to the n_f=5 values 0.1169(25) and
0.1187(32) at M_Z, respectively.Comment: 4 pages, 3 figures. Prepared for the Proceedings of the International
Workshop on e+e- collisions from Phi to Psi (PHIPSI11), Sep. 19-22, 2011,
BINP, Novosibirsk, Russi
Use of biological drugs in patients with psoriasis and psoriatic arthritis in italy: Results from the PSONG survey
This Italian multicenter retrospective study compared the drug survival and efficacy of differentanti-TNF agents in psoriasis (PsO) and psoriatic arthritis (PsA) patients. A database of PsO/PsApatients treated with adalimumab, etanercept, and infliximab from May 2013 to May 2014 wasanalyzed. PASI 75, 90, and 100 was calculated at each time point to evaluate efficacy. Drug sur-vival rate and probability of maintaining PASI response were evaluated. The impact of dependentvariables on probability of PASI 75 loss was evaluated by logistic regression. 1,235 patients wereincluded, 577 with PsO and 658 with PsA. Highest survival rates were observed with adalimumabfollowed by etanercept and infliximab in PsO and PsA patients. The probability of maintainingPASI response was significantly higher for adalimumab followed by infliximab. For PsO patients,the odds of losing PASI 75 was higher in etanercept-treated patients (OR: 8.1; 95% CI: 4.2–15.6,p<.001) or infliximab (OR: 6.6; 95% CI: 2.6–16.3,p<.001) vs. adalimumab. Likewise, for PsApatients the odds of losing PASI 75 was higher in etanercept-treated patients (OR: 2.3; 95% CI:1.4–3.8,p5.01) or infliximab (OR: 2.2; 95% CI: 1.1–4.1,p5.018) vs. adalimumab. Adalimumabcould be the best therapeutic option over other anti-TNF agents for the treatment of PsO and PsApatients
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