A Novel Approach to Discontinuous Bond Percolation Transition

We introduce a bond percolation procedure on a $D$-dimensional lattice where two neighbouring sites are connected by $N$ channels, each operated by valves at both ends. Out of a total of $N$, randomly chosen $n$ valves are open at every site. A bond is said to connect two sites if there is at least one channel between them, which has open valves at both ends. We show analytically that in all spatial dimensions, this system undergoes a discontinuous percolation transition in the $N\to \infty$ limit when $\gamma =\frac{\ln n}{\ln N}$ crosses a threshold. It must be emphasized that, in contrast to the ordinary percolation models, here the transition occurs even in one dimensional systems, albeit discontinuously. We also show that a special kind of discontinuous percolation occurs only in one dimension when $N$ depends on the system size.Comment: 6 pages, 6 eps figure

Comparison of Modules of Wild Type and Mutant Huntingtin and TP53 Protein Interaction Networks: Implications in Biological Processes and Functions

Disease-causing mutations usually change the interacting partners of mutant proteins. In this article, we propose that the biological consequences of mutation are directly related to the alteration of corresponding protein protein interaction networks (PPIN). Mutation of Huntingtin (HTT) which causes Huntington's disease (HD) and mutations to TP53 which is associated with different cancers are studied as two example cases. We construct the PPIN of wild type and mutant proteins separately and identify the structural modules of each of the networks. The functional role of these modules are then assessed by Gene Ontology (GO) enrichment analysis for biological processes (BPs). We find that a large number of significantly enriched (p<0.0001) GO terms in mutant PPIN were absent in the wild type PPIN indicating the gain of BPs due to mutation. Similarly some of the GO terms enriched in wild type PPIN cease to exist in the modules of mutant PPIN, representing the loss. GO terms common in modules of mutant and wild type networks indicate both loss and gain of BPs. We further assign relevant biological function(s) to each module by classifying the enriched GO terms associated with it. It turns out that most of these biological functions in HTT networks are already known to be altered in HD and those of TP53 networks are altered in cancers. We argue that gain of BPs, and the corresponding biological functions, are due to new interacting partners acquired by mutant proteins. The methodology we adopt here could be applied to genetic diseases where mutations alter the ability of the protein to interact with other proteins.Comment: 35 pages, 10 eps figures, (Supplementary material and Datasets are available on request

Negative Differential Mobility in Interacting Particle Systems

Driven particles in presence of crowded environment, obstacles or kinetic constraints often exhibit negative differential mobility (NDM) due to their decreased dynamical activity. We propose a new mechanism for complex many-particle systems where slowing down of certain {\it non-driven} degrees of freedom by the external field can give rise to NDM. This phenomenon, resulting from inter-particle interactions, is illustrated in a pedagogical example of two interacting random walkers, one of which is biased by an external field while the same field only slows down the other keeping it unbiased. We also introduce and solve exactly the steady state of several driven diffusive systems, including a two species exclusion model, asymmetric misanthrope and zero-range processes, to show explicitly that this mechanism indeed leads to NDM.Comment: 5 pages, 3 figure

Fixed-Energy Sandpiles Belong Generically to Directed Percolation

Fixed-energy sandpiles with stochastic update rules are known to exhibit a nonequilibrium phase transition from an active phase into infinitely many absorbing states. Examples include the conserved Manna model, the conserved lattice gas, and the conserved threshold transfer process. It is believed that the transitions in these models belong to an autonomous universality class of nonequilibrium phase transitions, the so-called Manna class. Contrarily, the present numerical study of selected (1+1)-dimensional models in this class suggests that their critical behavior converges to directed percolation after very long time, questioning the existence of an independent Manna class.Comment: article (4 pages, 9 eps figures) + Supplement (8 pages, 9 eps figures); Phys. Rev. Lett. 201

Adaptive finite element analysis based on p-convergence

The results of numerical experiments are presented in which a posteriori estimators of error in strain energy were examined on the basis of a typical problem in linear elastic fracture mechanics. Two estimators were found to give close upper and lower bounds for the strain energy error. The potential significance of this is that the same estimators may provide a suitable basis for adaptive redistribution of the degrees of freedom in finite element models