Crisis state of forwarding companies as a result of violation of external and internal stability

В статье рассматривается процесс возникновения кризисного состояния внутри транспортно-экспедиторских компаний как следствие негативных проявлений неопределенности внешней среды, а также причин внутреннего характера. Прослеживается связь между причинами и последствиями кризисного состояния транспортно-экспедиторских компаний, классифицируются факторы, обуславливающие недополучение финансовых поступлений этими компаниями

Phenolic compounds in plants: biogenesis and functions

Phenolic compounds (PCs) in plants play an important role in growth control and have antioxidant, structural, attractant, signaling and protective functions. Information on the discovery, study and identification of phenolic compounds in plants, their role in the complex system of secondary metabolites has been analyzed and summarized. The functions of PCs at the macromolecular, cellular as well as organism and population levels are described. The pathways of PCs formation, enzymes responsible for their synthesis and the plasticity of the synthesis in a plant cell are highlighted. The involvement of PCs in the plant breathing, photosynthesis, oxidation-reduction processes and regulation of the plants physiological state are discussed

Model for initiation of quality factor degradation at high accelerating fields in superconducting radio-frequency cavities

A model for the onset of the reduction in SRF cavity quality factor, the so-called Q-drop, at high accelerating electric fields is presented. Breakdown of the surface barrier against magnetic flux penetration at the cavity equator is considered to be the critical event that determines the onset of Q-drop. The worst case of triangular grooves with low field of first flux penetration Hp, as analyzed previously by Buzdin and Daumens, [1998 Physica C 294: 257], was adapted. This approach incorporates both the geometry of the groove and local contamination via the Ginzburg-Landau parameter kappa, so the proposed model allows new comparisons of one effect in relation to the other. The model predicts equivalent reduction of Hp when either roughness or contamination were varied alone, so smooth but dirty surfaces limit cavity performance about as much as rough but clean surfaces do. When in combination, contamination exacerbates the negative effects of roughness and vice-versa. To test the model with actual data, coupons were prepared by buffered chemical polishing and electropolishing, and stylus profilometry was used to obtain distributions of angles. From these data, curves for surface resistance generated by simple flux flow as a function of magnetic field were generated by integrating over the distribution of angles for reasonable values of kappa. This showed that combined effects of roughness and contamination indeed reduce the Q-drop onset field by ~30%, and that that contamination contributes to Q-drop as much as roughness. The latter point may be overlooked by SRF cavity research, since access to the cavity interior by spectroscopy tools is very difficult, whereas optical images have become commonplace. The model was extended to fit cavity test data, which indicated that reduction of the superconducting gap by contaminants may also play a role in Q-drop.Comment: 15 pages with 7 figure

ВПЛИВ БЛОКАДИ Ш-СИНТАЗИ НА ВАЗОДИЛАТАЦІЙНИЙ ЕФЕКТ ДІЕТИЛОВОГО ЕСТЕРУ 5-АЛКІЛАМІНО-2-{М-[М-БЕНЗОЇЛ-(4-МЕТИЛБЕНЗИЛІДЕН) ГЛІЦИЛ] АМІНОМЕТИЛ}-1,3-ОКСАЗОЛ-4-ІЛФОСФОНОВОЇ КИСЛОТИ НА СЕГМЕНТАХ ІЗОЛЬОВАНОЇ АОРТИ ЩУРІВ

INFLUENCE OF NO - SYNTHASE BLOCKADE ON VASODILATORY EFFECT OF DIETHYL ESTER OF 5-ALKILAMINE-2-{N-[N-BENZOYL-(4-METHYLBENZILIDEN) GLYCYL] AMINOMETHYL}- 1,3 - OXASOL-4-YLPHOSPHONIC ACID ON RAT’S ISOLATED AORTA I.V. Nizhenkovska1, A.V. Romanenko1, K.V. Sedko1, M.М. Grusha1, V.S. Brovarets2, A.V. Golovchenko21 Bogomolets National Medical University2 Institute of Bioorganic Chemistry and Petrochemistry at NAS of Ukraine Essential hypertension, hypertensive heart disease, secondary hypertension and related diseases caused by them are the result of a lot of pathological changes in the cardiovascular system. One of the main mechanisms which affects the blood pressure is increasing of the tone of smooth muscle vascular wall component.A significant number of endogenous vasodilators exert their activity by mechanisms which are directly or indirectly related to the production of nitric oxide by endothelial cells, so the effects associated with its release, is a target for pharmacological correction of muscle tone in clinical practice.Previously, it was found that phosphorylated peptidomimetics, which are derivatives of 1,3-oxazole, have vasodilatative effects. However, the contribution of mechanisms of NO production and its release on vasotropic action of these compounds was not researched. That`s why the aim of our experiment was to study the vasodilatative effects of new synthesized derivative of 1,3-oxazole - diethyl ester of 5-alkilamine-2-{N-[N-benzoyl-(4-methylbenziliden) glycyl] aminomethyl}- 1,3 - oxasol-4-ylphosphonic acid (oxazole containing peptidomimetic) on rat’s isolated aorta on the background of the NO-synthase blockade.For experiment it was used isolated segments (n=5) of the thoracic descending aorta of Wistar rats with average weight 200-250 g. Received aortic segments before the experiment were kept at least 30 minutes at a temperature 35-37 °C in Krebs solution. To register the tone of aortic segments it was used installation consisting of a flow chamber (volume - 2 ml) at 36,5 °C.Vasodilatative activity of the compound was estimated by the effect on basal tone and amplitude of smooth muscle contraction of blood vessels in response to the including of α1-adrenoreceptor agonist -adrenalin (5•10-6 M) in the incubation medium. In assessing the effectiveness of vasoactive impact of the researched substance as 100% was taken the amplitude of tonic contraction of muscle in control in response to adrenaline (5•10-6 M) application for 10 sec.Average amplitude of adrenoreaction in control was 3,34 ± 1,07 mN. Adding of NO-synthase blocker - L-NAME (1•10-4 M) to Krebs solution had not an effect on basal tone of smooth muscles isolated segment of the thoracic descending aorta. However, the adding of L-NAME (1•10-4 M) to perfusate caused increasing the amplitude of adrenoreaction on 71% from baseline on 90th minute. The received changes in the amplitude are probably related to the blockade by L-NAME of NO production and release, and reducing the effect of vasodilatative component in providing the vascular reactivity to the action of α1-adrenergic receptors agonist - adrenaline (5•10-6 M).Additional including of oxazole containing peptidomimetic (1•10-5 M) to perfusate, after 30 minutes from beginning of application caused the amplitude reduction of adrenoreaction by 33% comparatively with its amplitude in conditions of only L-NAME (1•10-4 M) presence in the perfusate.The effect, which was caused by the including of oxazole containing peptidomimetic (1•10-5 M) to Krebs solution, was reversible. Within 30 min after removing of the last substance of perfusate, amplitude of adrenoreaction increased by 26% comparatively with its amplitude in conditions of simultaneous presence both of these compounds in solution. L-NAME removing of Krebs solution lead to regular amplitude decreasing of adrenoreaction.Experiments, conducted by using isolated segments of the rat`s thoracic descending aorta give reason to consider that diethyl ester of 5-alkilamine-2-{N-[N-benzoyl-(4-methylbenziliden) glycyl] aminomethyl}- 1,3 - oxasol-4-ylphosphonic acid (1•10-5 M) is able to keep its vasodilatative properties in conditions of NO-synthase blockade. The fact of saving of oxazole containing peptidomimetic effective action on the background of NO-synthase blockade by L-NAME (1•10-4 M) shows that vasodilatative effect of these two compounds is realized through various targets. Therefore, further study of vasodilatative mechanism of test compound, which can be used as potential antihypertensive medicine, is perspective for next researches.Literature:International Classification of Diseases 10th revision [Electron resource]. - Access: httpHYPERLINK "http://mkb-10.com/"://HYPERLINK "http://mkb-10.com/"mkbHYPERLINK "http://mkb-10.com/"-10.HYPERLINK "http://mkb-10.com/"comHYPERLINK "http://mkb-10.com/"/.Nizhenkovskaya I.V. The influence of sufan on myocardial energetic metabolism in case of  adriamycin-induced heart failure. / Nizhenkovskaya I.V. // Research Trends. Current Topics in Pharmacology. Short Communication. SCOPUS. – 2013. - 17, 1. – P. 103-108.Mishichnie tkani: uchebnoe posobie dlya vuzov / U.S. Chentsov, Е.А. Shubnicova, N.А. Yurina, N.B. Gusev.  - М.: Medicina, 2001. -  256 s.Ryabov G.А. Rol` oxida azota kak regulyatora kletochnih protsessov pri formirovanii poliorgannoy nedostatochnosti / Ryabov G.А., Аzizov Yu.М. // Аnesteziologia I reanimatologia. – 2008. - №1. – S. 8-13.I.N. Yakovenko. The synthesis and investigation of vasoactive properties of new phosphorylated peptidomimetics / I.N. Yakovenko, O.I. Lukashuk, K.M. Kondratyuk, A.V. Golovchenko, V.V. Zhyrnov, V.S. Brovarets // Journal of Organic and Pharmaceutical Chemistry. – 2013. - V. 11, Iss. 3 (43). – Р. 43-50.Doclinichni doslidzhennya likarskih zasobiv (metodichni rekomendacii) / Za red. О.V. Stefanova. – К.: VD «Аvicena», 2002. – 527 s.Blattner R. Experimenti na isolirovannih preparatah gladkih mishts / Blattner R., Klassen H., Denert H. i dr. - М. : Мir, 1983.- 206 s.Lukiantseva G.V. Dinamika sokratitelnoy aktivnosti isolirovannogo kolcevogo preparata aorti kris pod vliyaniem amilina/ Lukiantseva G.V., Sergeev I.U., Pastuhova V.А., Gunina L.M. // Ukrainskiy morfologichniy almanah. – 2013. – Т. 11, №1. - S. 77-78.Paulis L. Regression of L-NAME-induced hypertension: the role of Nitric oxide and endothelium-derived constricting factor / Paulis L., Zicha J., Kunes J. and others // Hipertension research. – 2008. - № 31. – P. 793-803.Moslemi F. Inhibition of Nitric oxide synthase by L-NAME in male rats / Moslemi F., Nematbakhsh M. and others // Intarnational scholarly research notices: Toxicology. – 2013. – V. 2013. – P. 227-232

Implantation surgery for the treatment of urinary incontinence. Analysis of the immediate and long-term complications

In the clinic of urology Federal State Budgetaiy Institution of Higher Professional Education «Urals State Medical University» of the Minisby of Healthcare of the Russian Federation on the basis of «Sverdlovsk regional clinical hospital № 1»conducted a retrospective analysis of complications after implantation correction of urinary incontinence in men and women through a variety of sling operations, as well as the installation of an artificial urinary sphincter. Achieved 44 retrobulbar sling implantation systems Argus T and artificial sphincter AMS-800 of the bladder in men and 536 different systems implanted like TVTI TVT-0 in women with stress urinary incontinence. We obtained results: success was achieved in 66.7% of patients after implantation retrobulbar sling (complications was observed in 13.3%) patients with bladder sphincter implanted clinical efficacy was 76% (complications was observed abserved 172%); women in 97.8% of cases managed to achieve a positive effect, and eliminate stress incontinence, and the incidence of complications was 9.6% (total 49 patients). We came to the conclusion about the importance of proper selection of readings to a variant of implant technique in men, that is the key tojhe success of the operation, correcting urinary incontinence. Implantation method synthetic slings at stessovom incontinence in women is a minimally invasive, safe, low level of postoperative complications.В клинике урологии ФГБОУ ВО УГМУ Минздрава России на базе ГБУЗ СО «Свердловская ОКБ №1» проведен ретроспективный анализ осложнений после имплантационной коррекции недержания мочи у мужчин и женщин с помощью различных слинговых операций, а также установки искусственного сфинктера мочевого пузыря. Выполнено 44 имплантации систем ретробульбарного слинга Аргус Т и искусственного сфинктера мочевого пузыря AMS-800 у мужчин, атакже имплантировано 536 различных систем TVT/TVT-0 у женщин со стрессовым недержанием мочи. Нами получены реультаты: успех был достигнут у 66,7% пациентов после имплантации ретробульбарного слинга (осложнения наблюдались в 13,3%), у пациентов с имплантированным сфинктером мочевого пузыря клиническая эффективность составила 76% (осложнения наблюдались в 17,2%); у женщин в 97,8% случаев удалось добиться положительного эффекта и ликвидировать стрессовое недержание мочи, при этом частота осложнений составила 9,6% (всего 49). Мы пришли к выводу о важности правильного выбора показания к варианту имплантационной методики у мужчин, что является залогом успеха операции, коррегирующей мочевую инконтиненцию. Метод имплантации синтетической слингов при стрессовом недержании мочи у женщин является малоинвазивным, безопасным, с низким уровнем послеоперационных осложнений

Upper limits on the isotropic diffuse flux of cosmic PeV photons from Carpet-2 observations

Isotropic diffuse gamma-ray flux in the PeV energy band is an important tool for multimessenger tests of models of the origin of high-energy astrophysical neutrinos and for new-physics searches. So far, this flux has not yet been observed. Carpet-2 is an air-shower experiment capable of detecting astrophysical gamma rays with energies above 0.1 PeV. Here we report the upper limits on the isotropic gamma-ray flux from Carpet-2 data obtained in 1999-2011 and 2018-2022. These results, obtained with the new statistical method based on the shape of the muon-number distribution, summarize Carpet-2 observations as the upgraded installation, Carpet-3, starts its operation.Comment: 5 pages, 3 figures, JETPL.cls; V2: references added, version accepted by JETP Letter