1,005 research outputs found
Vaccination and clinical severity: Is the effectiveness of contact tracing and case isolation hampered by past vaccination?
published_or_final_versio
Contact behaviour of children and parental employment behaviour during school closures against the pandemic influenza A (H1N1-2009) in Japan
published_or_final_versio
NK4, a four-kringle antagonist of HGF, inhibits spreading and invasion of human pancreatic cancer cells
Because of the highly aggressive behaviour, i.e. invasive, disseminative and metastatic properties, the outcome for patients with pancreatic cancer is morbid. A better understanding and interference with the malignant behaviour of pancreatic cancer may provide new directions for treatment. We report here the induction of highly motile and invasive properties in human pancreatic cancer cells by hepatocyte growth factor (HGF) and blockage of these properties by NK4, a newly identified antagonist for HGF. In all of eight human pancreatic cancer cell lines we used (AsPC-1, BxPC-3, H-48N, KP-1N, KP-2, KP-3, MIA PaCa-2 and SUIT-2 cells), the c-Met/HGF receptor was expressed at varying levels. Although weak mitogenic activity of HGF was seen only in SUIT-2 and KP-3 cells, HGF strongly stimulated migration and invasion of these pancreatic cancer cells, except for BxPC-3 and MIA PaCa-2 cells. In contrast, migration and invasion potently induced by HGF in KP-1N, KP-3 and SUIT-2 cells were inhibited by NK4. The invasion of SUIT-2 cells was also potently stimulated with the influence of cocultured pancreatic fibroblasts and by ascitic fluid obtained after pancreatic cancer resection, however, invasiveness of the cancer cells in such conditions was practically abolished by NK4. Consistently, the ascitic fluid in patients who had undergone pancreatic cancer surgery contained high levels of HGF. These findings mean that HGF is probably involved in invasion, dissemination, and metastasis of pancreatic cancer, particularly through tumour-stromal interaction and after resection of the pancreatic cancer. NK4, an effective antagonist of HGF, may prove to have the potential for anti-invasion/metastasis. © 2001 Cancer Research Campaign http://www.bjcancer.co
EAS development curve at energy of 10(16) - 10(18) eV measured by optical Cerenkov light
The data of optical Cerenkov light from extensive air shower observed at the core distance more than 1 Km at Akeno are reexamined. Applying the new simulated results, the shower development curves for the individual events were constructed. For the showers of 10 to 17th power eV the average depth at the shower maximum is determined to be 660 + or - 40 gcm/2. The shower curve of average development is found to be well described by a Gaisser-Hillas shower development function with above shower maximum depth
An Electron-Tracking Compton Telescope for a Survey of the Deep Universe by MeV gamma-rays
Photon imaging for MeV gammas has serious difficulties due to huge
backgrounds and unclearness in images, which are originated from incompleteness
in determining the physical parameters of Compton scattering in detection,
e.g., lack of the directional information of the recoil electrons. The recent
major mission/instrument in the MeV band, Compton Gamma Ray
Observatory/COMPTEL, which was Compton Camera (CC), detected mere
persistent sources. It is in stark contrast with 2000 sources in the GeV
band. Here we report the performance of an Electron-Tracking Compton Camera
(ETCC), and prove that it has a good potential to break through this stagnation
in MeV gamma-ray astronomy. The ETCC provides all the parameters of
Compton-scattering by measuring 3-D recoil electron tracks; then the Scatter
Plane Deviation (SPD) lost in CCs is recovered. The energy loss rate (dE/dx),
which CCs cannot measure, is also obtained, and is found to be indeed helpful
to reduce the background under conditions similar to space. Accordingly the
significance in gamma detection is improved severalfold. On the other hand, SPD
is essential to determine the point-spread function (PSF) quantitatively. The
SPD resolution is improved close to the theoretical limit for multiple
scattering of recoil electrons. With such a well-determined PSF, we demonstrate
for the first time that it is possible to provide reliable sensitivity in
Compton imaging without utilizing an optimization algorithm. As such, this
study highlights the fundamental weak-points of CCs. In contrast we demonstrate
the possibility of ETCC reaching the sensitivity below erg
cm s at 1 MeV.Comment: 19 pages, 12 figures, Accepted to the Astrophysical Journa
Study of composition of cosmic rays with energy .7 E 3 Ee
The longitudinal shower development of extensive air showers (EAS) observed in the fly's eye is used to determine the distribution of X sub max, the depth in the atmosphere of the EAS maximum. Data and Monte Carlo simulations of proton and iron primaries are compared. A substantial contribution from light primaries is noted
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