441 research outputs found
User's Guide for Flight Simulation Data Visualization Workstation
Today's modern flight simulation research produces vast amounts of time sensitive data. The meaning of this data can be difficult to assess while in its raw format. Therefore, a method of breaking the data down and presenting it to the user in a graphical format is necessary. Simulation Graphics (SimGraph) is intended as a data visualization software package that will incorporate simulation data into a variety of animated graphical displays for easy interpretation by the simulation researcher. This document is intended as an end user's guide
The Complex Energy Landscape of the Protein IscU
AbstractIscU, the scaffold protein for iron-sulfur (Fe-S) cluster biosynthesis in Escherichia coli, traverses a complex energy landscape during Fe-S cluster synthesis and transfer. Our previous studies showed that IscU populates two interconverting conformational states: one structured (S) and one largely disordered (D). Both states appear to be functionally important because proteins involved in the assembly or transfer of Fe-S clusters have been shown to interact preferentially with either the S or D state of IscU. To characterize the complex structure-energy landscape of IscU, we employed NMR spectroscopy, small-angle x-ray scattering (SAXS), and differential scanning calorimetry. Results obtained for IscU at pH 8.0 show that its S state is maximally populated at 25°C and that heating or cooling converts the protein toward the D state. Results from NMR and DSC indicate that both the heat- and cold-induced S→D transitions are cooperative and two-state. Low-resolution structural information from NMR and SAXS suggests that the structures of the cold-induced and heat-induced D states are similar. Both states exhibit similar 1H-15N HSQC spectra and the same pattern of peptidyl-prolyl peptide bond configurations by NMR, and both appear to be similarly expanded compared with the S state based on analysis of SAXS data. Whereas in other proteins the cold-denatured states have been found to be slightly more compact than the heat-denatured states, these two states occupy similar volumes in IscU
Optimal control theory for unitary transformations
The dynamics of a quantum system driven by an external field is well
described by a unitary transformation generated by a time dependent
Hamiltonian. The inverse problem of finding the field that generates a specific
unitary transformation is the subject of study. The unitary transformation
which can represent an algorithm in a quantum computation is imposed on a
subset of quantum states embedded in a larger Hilbert space. Optimal control
theory (OCT) is used to solve the inversion problem irrespective of the initial
input state. A unified formalism, based on the Krotov method is developed
leading to a new scheme. The schemes are compared for the inversion of a
two-qubit Fourier transform using as registers the vibrational levels of the
electronic state of Na. Raman-like transitions through the
electronic state induce the transitions. Light fields are found
that are able to implement the Fourier transform within a picosecond time
scale. Such fields can be obtained by pulse-shaping techniques of a femtosecond
pulse. Out of the schemes studied the square modulus scheme converges fastest.
A study of the implementation of the qubit Fourier transform in the Na
molecule was carried out for up to 5 qubits. The classical computation effort
required to obtain the algorithm with a given fidelity is estimated to scale
exponentially with the number of levels. The observed moderate scaling of the
pulse intensity with the number of qubits in the transformation is
rationalized.Comment: 32 pages, 6 figure
Speakable in Quantum Mechanics
At the 1927 Como conference Bohr spoke the now famous words "It is wrong to
think that the task of physics is to find out how nature is. Physics concerns
what we can say about nature." However, if the Copenhagen interpretation really
holds on to this motto, why then is there this feeling of conflict when
comparing it with realist interpretations? Surely what one can say about nature
should in a certain sense be interpretation independent. In this paper I take
Bohr's motto seriously and develop a quantum logic that avoids assuming any
form of realism as much as possible. To illustrate the non-triviality of this
motto a similar result is first derived for classical mechanics. It turns out
that the logic for classical mechanics is a special case of the derived quantum
logic. Finally, some hints are provided in how these logics are to be used in
practical situations and I discuss how some realist interpretations relate to
these logics
Antitumor activity and safety of the PARP inhibitor rucaparib in patients with high grade ovarian carcinoma and a germline or somatic BRCA1 or BRCA2 mutation: integrated analysis of data from Study 10 and ARIEL2
Objective:
An integrated analysis was undertaken to characterize the antitumor activity and safety profile of the oral poly(ADP-ribose) polymerase inhibitor rucaparib in patients with relapsed high-grade ovarian carcinoma (HGOC).
Methods:
Eligible patients from Study 10 (NCT01482715) and ARIEL2 (NCT01891344) who received a starting dose of oral rucaparib 600 mg twice daily (BID) with or without food were included in these analyses. The integrated efficacy population included patients with HGOC and a deleterious germline or somatic BRCA1 or BRCA2 (BRCA1/2) mutation who received at least two prior chemotherapies and were sensitive, resistant, or refractory to platinum-based chemotherapy. The primary endpoint was investigator-assessed confirmed objective response rate (ORR). Secondary endpoints included duration of response (DOR) and progression-free survival (PFS). The integrated safety population included patients with HGOC who received at least one dose of rucaparib 600 mg BID, irrespective of BRCA1/2 mutation status and prior treatments.
Results:
In the efficacy population (n = 106), ORR was 53.8% (95% confidence interval [CI], 43.8–63.5); 8.5% and 45.3% of patients achieved complete and partial responses, respectively. Median DOR was 9.2 months (95% CI, 6.6–11.6). In the safety population (n = 377), the most frequent treatment-emergent adverse events (AEs) were nausea, asthenia/fatigue, vomiting, and anemia/hemoglobin decreased. The most common grade ≥ 3 treatment-emergent AE was anemia/hemoglobin decreased. Treatment-emergent AEs led to treatment interruption, dose reduction, and treatment discontinuation in 58.6%, 45.9%, and 9.8% of patients, respectively. No treatment-related deaths occurred.
Conclusions:
Rucaparib has antitumor activity in advanced BRCA1/2-mutated HGOC and a manageable safety profile
Experimental Implementation of the Deutsch-Jozsa Algorithm for Three-Qubit Functions using Pure Coherent Molecular Superpositions
The Deutsch-Jozsa algorithm is experimentally demonstrated for three-qubit
functions using pure coherent superpositions of Li rovibrational
eigenstates. The function's character, either constant or balanced, is
evaluated by first imprinting the function, using a phase-shaped femtosecond
pulse, on a coherent superposition of the molecular states, and then projecting
the superposition onto an ionic final state, using a second femtosecond pulse
at a specific time delay
Sensitivity to measurement perturbation of single atom dynamics in cavity QED
We consider continuous observation of the nonlinear dynamics of single atom
trapped in an optical cavity by a standing wave with intensity modulation. The
motion of the atom changes the phase of the field which is then monitored by
homodyne detection of the output field. We show that the conditional Hilbert
space dynamics of this system, subject to measurement induced perturbations,
depends strongly on whether the corresponding classical dynamics is regular or
chaotic. If the classical dynamics is chaotic the distribution of conditional
Hilbert space vectors corresponding to different observation records tends to
be orthogonal. This is a characteristic feature of hypersensitivity to
perturbation for quantum chaotic systems.Comment: 11 pages, 6 figure
Induction of Human β-Cell Proliferation and Engraftment Using a Single G1/S Regulatory Molecule, cdk6
Trace formulas for stochastic evolution operators: Smooth conjugation method
The trace formula for the evolution operator associated with nonlinear
stochastic flows with weak additive noise is cast in the path integral
formalism. We integrate over the neighborhood of a given saddlepoint exactly by
means of a smooth conjugacy, a locally analytic nonlinear change of field
variables. The perturbative corrections are transfered to the corresponding
Jacobian, which we expand in terms of the conjugating function, rather than the
action used in defining the path integral. The new perturbative expansion which
follows by a recursive evaluation of derivatives appears more compact than the
standard Feynman diagram perturbation theory. The result is a stochastic analog
of the Gutzwiller trace formula with the ``hbar'' corrections computed an order
higher than what has so far been attainable in stochastic and
quantum-mechanical applications.Comment: 16 pages, 1 figure, New techniques and results for a problem we
considered in chao-dyn/980703
Radio Astronomy
Contains reports on three research project.National Science Foundation (Grant GP-21348A#2)California Institute of Technology (Contract 952568)National Aeronautics and Space Administration (Grant NGR 22-009-421)U. S. Air Force - Electronic Systems Division (Contract F19628-73-C-0196
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