User's Guide for Flight Simulation Data Visualization Workstation

Today's modern flight simulation research produces vast amounts of time sensitive data. The meaning of this data can be difficult to assess while in its raw format. Therefore, a method of breaking the data down and presenting it to the user in a graphical format is necessary. Simulation Graphics (SimGraph) is intended as a data visualization software package that will incorporate simulation data into a variety of animated graphical displays for easy interpretation by the simulation researcher. This document is intended as an end user's guide

The Complex Energy Landscape of the Protein IscU

AbstractIscU, the scaffold protein for iron-sulfur (Fe-S) cluster biosynthesis in Escherichia coli, traverses a complex energy landscape during Fe-S cluster synthesis and transfer. Our previous studies showed that IscU populates two interconverting conformational states: one structured (S) and one largely disordered (D). Both states appear to be functionally important because proteins involved in the assembly or transfer of Fe-S clusters have been shown to interact preferentially with either the S or D state of IscU. To characterize the complex structure-energy landscape of IscU, we employed NMR spectroscopy, small-angle x-ray scattering (SAXS), and differential scanning calorimetry. Results obtained for IscU at pH 8.0 show that its S state is maximally populated at 25°C and that heating or cooling converts the protein toward the D state. Results from NMR and DSC indicate that both the heat- and cold-induced S→D transitions are cooperative and two-state. Low-resolution structural information from NMR and SAXS suggests that the structures of the cold-induced and heat-induced D states are similar. Both states exhibit similar 1H-15N HSQC spectra and the same pattern of peptidyl-prolyl peptide bond configurations by NMR, and both appear to be similarly expanded compared with the S state based on analysis of SAXS data. Whereas in other proteins the cold-denatured states have been found to be slightly more compact than the heat-denatured states, these two states occupy similar volumes in IscU

Optimal control theory for unitary transformations

The dynamics of a quantum system driven by an external field is well described by a unitary transformation generated by a time dependent Hamiltonian. The inverse problem of finding the field that generates a specific unitary transformation is the subject of study. The unitary transformation which can represent an algorithm in a quantum computation is imposed on a subset of quantum states embedded in a larger Hilbert space. Optimal control theory (OCT) is used to solve the inversion problem irrespective of the initial input state. A unified formalism, based on the Krotov method is developed leading to a new scheme. The schemes are compared for the inversion of a two-qubit Fourier transform using as registers the vibrational levels of the $X^1\Sigma^+_g$ electronic state of Na$_2$. Raman-like transitions through the $A^1\Sigma^+_u$ electronic state induce the transitions. Light fields are found that are able to implement the Fourier transform within a picosecond time scale. Such fields can be obtained by pulse-shaping techniques of a femtosecond pulse. Out of the schemes studied the square modulus scheme converges fastest. A study of the implementation of the $Q$ qubit Fourier transform in the Na$_2$ molecule was carried out for up to 5 qubits. The classical computation effort required to obtain the algorithm with a given fidelity is estimated to scale exponentially with the number of levels. The observed moderate scaling of the pulse intensity with the number of qubits in the transformation is rationalized.Comment: 32 pages, 6 figure

Speakable in Quantum Mechanics

At the 1927 Como conference Bohr spoke the now famous words "It is wrong to think that the task of physics is to find out how nature is. Physics concerns what we can say about nature." However, if the Copenhagen interpretation really holds on to this motto, why then is there this feeling of conflict when comparing it with realist interpretations? Surely what one can say about nature should in a certain sense be interpretation independent. In this paper I take Bohr's motto seriously and develop a quantum logic that avoids assuming any form of realism as much as possible. To illustrate the non-triviality of this motto a similar result is first derived for classical mechanics. It turns out that the logic for classical mechanics is a special case of the derived quantum logic. Finally, some hints are provided in how these logics are to be used in practical situations and I discuss how some realist interpretations relate to these logics

Antitumor activity and safety of the PARP inhibitor rucaparib in patients with high grade ovarian carcinoma and a germline or somatic BRCA1 or BRCA2 mutation: integrated analysis of data from Study 10 and ARIEL2

Objective: An integrated analysis was undertaken to characterize the antitumor activity and safety profile of the oral poly(ADP-ribose) polymerase inhibitor rucaparib in patients with relapsed high-grade ovarian carcinoma (HGOC). Methods: Eligible patients from Study 10 (NCT01482715) and ARIEL2 (NCT01891344) who received a starting dose of oral rucaparib 600 mg twice daily (BID) with or without food were included in these analyses. The integrated efficacy population included patients with HGOC and a deleterious germline or somatic BRCA1 or BRCA2 (BRCA1/2) mutation who received at least two prior chemotherapies and were sensitive, resistant, or refractory to platinum-based chemotherapy. The primary endpoint was investigator-assessed confirmed objective response rate (ORR). Secondary endpoints included duration of response (DOR) and progression-free survival (PFS). The integrated safety population included patients with HGOC who received at least one dose of rucaparib 600 mg BID, irrespective of BRCA1/2 mutation status and prior treatments. Results: In the efficacy population (n = 106), ORR was 53.8% (95% confidence interval [CI], 43.8–63.5); 8.5% and 45.3% of patients achieved complete and partial responses, respectively. Median DOR was 9.2 months (95% CI, 6.6–11.6). In the safety population (n = 377), the most frequent treatment-emergent adverse events (AEs) were nausea, asthenia/fatigue, vomiting, and anemia/hemoglobin decreased. The most common grade ≥ 3 treatment-emergent AE was anemia/hemoglobin decreased. Treatment-emergent AEs led to treatment interruption, dose reduction, and treatment discontinuation in 58.6%, 45.9%, and 9.8% of patients, respectively. No treatment-related deaths occurred. Conclusions: Rucaparib has antitumor activity in advanced BRCA1/2-mutated HGOC and a manageable safety profile

Experimental Implementation of the Deutsch-Jozsa Algorithm for Three-Qubit Functions using Pure Coherent Molecular Superpositions

The Deutsch-Jozsa algorithm is experimentally demonstrated for three-qubit functions using pure coherent superpositions of Li$_{2}$ rovibrational eigenstates. The function's character, either constant or balanced, is evaluated by first imprinting the function, using a phase-shaped femtosecond pulse, on a coherent superposition of the molecular states, and then projecting the superposition onto an ionic final state, using a second femtosecond pulse at a specific time delay

Sensitivity to measurement perturbation of single atom dynamics in cavity QED

We consider continuous observation of the nonlinear dynamics of single atom trapped in an optical cavity by a standing wave with intensity modulation. The motion of the atom changes the phase of the field which is then monitored by homodyne detection of the output field. We show that the conditional Hilbert space dynamics of this system, subject to measurement induced perturbations, depends strongly on whether the corresponding classical dynamics is regular or chaotic. If the classical dynamics is chaotic the distribution of conditional Hilbert space vectors corresponding to different observation records tends to be orthogonal. This is a characteristic feature of hypersensitivity to perturbation for quantum chaotic systems.Comment: 11 pages, 6 figure

Trace formulas for stochastic evolution operators: Smooth conjugation method

The trace formula for the evolution operator associated with nonlinear stochastic flows with weak additive noise is cast in the path integral formalism. We integrate over the neighborhood of a given saddlepoint exactly by means of a smooth conjugacy, a locally analytic nonlinear change of field variables. The perturbative corrections are transfered to the corresponding Jacobian, which we expand in terms of the conjugating function, rather than the action used in defining the path integral. The new perturbative expansion which follows by a recursive evaluation of derivatives appears more compact than the standard Feynman diagram perturbation theory. The result is a stochastic analog of the Gutzwiller trace formula with the ``hbar'' corrections computed an order higher than what has so far been attainable in stochastic and quantum-mechanical applications.Comment: 16 pages, 1 figure, New techniques and results for a problem we considered in chao-dyn/980703

Radio Astronomy

Contains reports on three research project.National Science Foundation (Grant GP-21348A#2)California Institute of Technology (Contract 952568)National Aeronautics and Space Administration (Grant NGR 22-009-421)U. S. Air Force - Electronic Systems Division (Contract F19628-73-C-0196