1,074 research outputs found
Who Watches the Watchmen? An Appraisal of Benchmarks for Multiple Sequence Alignment
Multiple sequence alignment (MSA) is a fundamental and ubiquitous technique
in bioinformatics used to infer related residues among biological sequences.
Thus alignment accuracy is crucial to a vast range of analyses, often in ways
difficult to assess in those analyses. To compare the performance of different
aligners and help detect systematic errors in alignments, a number of
benchmarking strategies have been pursued. Here we present an overview of the
main strategies--based on simulation, consistency, protein structure, and
phylogeny--and discuss their different advantages and associated risks. We
outline a set of desirable characteristics for effective benchmarking, and
evaluate each strategy in light of them. We conclude that there is currently no
universally applicable means of benchmarking MSA, and that developers and users
of alignment tools should base their choice of benchmark depending on the
context of application--with a keen awareness of the assumptions underlying
each benchmarking strategy.Comment: Revie
Methodenvergleich fuer die Berechnung grosser Huellrohrdeformationen beim Kuehlmittelverlustunfall von Leichtwasserreaktoren
Jahresbericht der Arbeitsgruppe Brennstab- und Brennelementmechanik des Instituts fuer Reaktortechnik der Technischen Hochschule Darmstadt (Prof.Dr. W. Humbach)
Histopathological characterization of magnetic resonance imaging-decectable brain white matter lesions in a primate model of multiple sclerosis.
Jahresbericht der Arbeitsgruppe Brennstab- und Brennelementmechanik des Instituts fuer Reaktortechnik (IRT) der TH Darmstadt fuer das Projekt Schneller Brueter
Fine-Mapping Resolves Eae23 into Two QTLs and Implicates ZEB1 as a Candidate Gene Regulating Experimental Neuroinflammation in Rat
This study was supported by grants from the Swedish Research Council, The Wadsworth Foundation, Söderbergs Foundation, Petrus and Augusta Hedlunds Foundation, Bibbi and Niels Jensens Foundation, Montel Williams Foundation, Åke-Wibergs Stiftelse, the Swedish Foundation for Neurologically Disabled and the EU 6TH Framework EURATools (LSHG-CT-2005-019015) and Neuropromise (LSHM-CT-2005-018637)
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