A comparative study of the influence of physical factors on the survival and infectivity of miracidia of Schistosoma mansoni and S. haematobium

In this study the influence of physical factors on the survival and infectivity of S. mansoni and S.haematobium miracidia was compared. The physical factors studied include termperature, light, gravity, depth, hydrostatic pressure, host-parasite dispersion, rate of flow of water and turbulence, ultra-violet radiation and the length of contact time. While the influence of one physical factor was being investigated all the others were kept constant and the levels of each factor applied were chosen in order to include the limits that may be encountered in the field. The criteria for the influence of a physical factor on miracidia were the infection rates produced in susceptible snails. In some cases the factor was applied to the miracidia alone for a period of time before exposing the snails to them. Miracidia were examined under a dissecting microscope for mortality or degree of activity of survivors, where the factor (such as temperature or ultra-violet radiation) affected their metabolic rates. The degree of activity of miracidia which indicated the extent to which a physical factor affected them was described as "ACTIVE", "SLOW" or "LETHARGIC" and was quantified by calculating the mean rates of movement of miracidia in those categories. For factors which acted as stimuli, such as light and gravity, the responses of the miracidia were recorded as a positive or a negative taxis. The use of carefully designed apparatus and simplified methods made it possible to reproduce the experiments several times, and statistical analysis of the results helped to assess the significance of differences obtained. These studies have shown that the survival and infectivity of S.mansoni and S.haematobium miracidia were influenced in a very similar manner by the different physical factors and that both parasites have a remarkable capacity to locate, select and infect their snail hosts. It was found that they were not limited by depth, hydrostatic pressure or dispersion and that they were capable of infecting snail hosts in water flowing at moderate rates. The different responses of S.mansoni and S.haematobium miracidia to light and gravity appear to increase their chances of meeting their particular snail hosts. The use of the physical factors studied to interfere with the infective capacity of schistosome miracidia and thereby reduce transmission in endemic areas has been discussed

A missed cornual ectopic pregnancy: a case report

Ectopic pregnancies continue to be among the leading causes of maternal mortality globally. Cornual pregnancies are types of ectopic pregnancies that occur in the interstitial part of the fallopian tube and invades the uterine wall. We report a case of cornual ectopic pregnancy at 26 weeks that was missed and only diagnosed at autopsy following rupture and death of the pregnant woman. This case emphasizes the importance of a detailed carefully performed ultrasonography in the first trimester for all pregnant women.

Consequences of International Financial Reporting Standards Adoption in Africa: Evidence From Foreign Direct Investment

International Financial Reporting Standards (IFRS) Adoption makes financial reporting transparent by enhancing the comparability and the quality of the financial information which reduces the transaction cost and attract foreign direct investment (FDI). This consequently facilitates the effective economic decisions of investors and other market participants. In light of this, many developing countries, in Africa, have resorted to the mandatory-IFRS adoption to enhance the inflow of foreign capital. The study, therefore, aims at finding out the effect of IFRS adoption on FDI inflows. We investigate whether the adoption of IFRS really enhances the inflow of foreign direct investment in developing countries.We use the Fixed Effect regression model, and the sample consisted of 45 (30 IFRS adopted and 15 IFRS non-adopted) African countries from the period of 2000 to 2017. The evidence from our study shows that the adoption of IFRS leads to increased FDI inflows. Most research on international financial reporting standard and foreign direct investment did not control the time period. By conducting further analysis using the difference-in-difference analysis to control the time period, our results highlighted that FDI inflows is higher after the adoption of IFRS. The increase in the value of FDI is influenced by the time period

Convex Regularization Method for Solving Cauchy Problem of the Helmholtz Equation

In this paper, we introduce the Convex Regularization Method (CRM) for regularizing the (instability) solution of the Helmholtz equation with Cauchy data. The CRM makes it possible for the solution of Helmholtz equation to depend continuously on the small perturbations in the Cauchy data. In addition, the numerical computation of the reg- ularized Helmholtz equation with Cauchy data is stable, accurate and gives high rate of convergence of solution in Hilbert space. Undoubtedly, the error estimated analysis associated with CRM is minimal.Mathematics Subject Classi cation: 44B28; 44B30Keywords: Convex Regularization Method, ill-posed Helmholtz equation with Cauchy data, stable solutio

The prevalence of, and factors associated with, paying for sex among men resident in Britain: findings from the third national survey of sexual attitudes and lifestyles (Natsal-3)

Objectives Men who pay for sex (MPS) are considered a bridging population for sexually transmitted infections (STI). However, the extent, characteristics and role of MPS in transmission is poorly understood. We investigate these questions using data from Britain's third National Survey of Sexual Attitudes and Lifestyles (Natsal-3). Methods We performed complex survey analyses of data from 6293 men aged 16–74 years resident in Britain who completed Natsal-3, a probability sample survey undertaken during 2010–2012, using computer-assisted personal interviewing and computer-assisted self-interview. Results 11.0% (95% CI10.1% to 11.9%) of all men reported ever paying for sex. Among MPS, 18.4% (95% CI 18.2% to 18.7%) of their lifetime sexual partners were paid. 3.6% (95% CI 3.1% to 4.2%) of men had paid for sex in the past 5 years. Partners of MPS constitute 14.7% of all reported partners and MPS report 15.6% of all reported STI diagnoses in the past 5 years. Paying for sex in the past 5 years was strongly associated with reporting larger numbers of sexual partners (adjusted OR, AOR for 5+ partners, past 5 years, 31.50, 95% CI 18.69 to 53.09). After adjusting for partner numbers, paying for sex remained strongly associated with reporting new foreign partners outside the UK (AOR 7.96; 95% CI 4.97 to 12.73) and STI diagnosis/es (AOR 2.34; 95% CI 1.44 to 3.81), all in the past 5 years. Among men ever paying for sex, 62.6% (95% CI 58.3% to 66.8%) reported paying for sex outside the UK, most often in Europe and Asia. Conclusions MPS in Britain remain at greater risk of STI acquisition and onward transmission than men who do not. They report high numbers of partners, but the minority are paid partners. They are an important core group in STI transmission

Human papillomavirus DNA in men who have sex with men: type-specific prevalence, risk factors and implications for vaccination strategies.

BACKGROUND: Human papillomavirus (HPV) vaccination of girls will have relatively little effect on HPV-related disease in men who have sex with men (MSM). We determined HPV prevalence and risk factors in MSM to inform the potential effectiveness of vaccinating MSM. METHODS: Cross-sectional study of 522 MSM aged 18-40 attending a London sexual health clinic who completed a computer-assisted self-interview. Urine and two swabs (anal and penile/scrotal/perianal) were collected and tested using an in-house Luminex-based HPV genotyping system. RESULTS: Prevalence of DNA of the vaccine-preventable HPV types in ano-genital specimens of men was 87/511 (17.0%), 166/511 (32.5%) and 232/511 (45.4%) for the bivalent (HPV16/18), quadrivalent (HPV6/11/16/18) and nonavalent (HPV6/11/16/18/31/33/45/52/58) vaccine types, respectively. A total of 25.1% had one of the quadrivalent types, and 7.4% had 2+ types. Median age at first anal sex was 19 (IQR 17-23) and at first clinic attendance was 24 (IQR 20-27). The increase in the odds of any HPV infection per year of age was 4.7% (95% CI 1.2-8.4). CONCLUSIONS: On the basis of the current infection status, most MSM, even among a high-risk population attending a sexual health clinic, are not currently infected with the vaccine-type HPV. A targeted vaccination strategy for MSM in the UK could have substantial benefits

The prevalence of, and factors associated with, paying for sex among men resident in Britain: findings from the third National Survey of Sexual Attitudes and Lifestyles (Natsal-3)

Objectives Men who pay for sex (MPS) are considered a bridging population for sexually transmitted infections (STI). However, the extent, characteristics and role of MPS in transmission is poorly understood. We investigate these questions using data from Britain's third National Survey of Sexual Attitudes and Lifestyles (Natsal-3). Methods We performed complex survey analyses of data from 6293 men aged 16–74 years resident in Britain who completed Natsal-3, a probability sample survey undertaken during 2010–2012, using computer-assisted personal interviewing and computer-assisted self-interview. Results 11.0% (95% CI10.1% to 11.9%) of all men reported ever paying for sex. Among MPS, 18.4% (95% CI 18.2% to 18.7%) of their lifetime sexual partners were paid. 3.6% (95% CI 3.1% to 4.2%) of men had paid for sex in the past 5 years. Partners of MPS constitute 14.7% of all reported partners and MPS report 15.6% of all reported STI diagnoses in the past 5 years. Paying for sex in the past 5 years was strongly associated with reporting larger numbers of sexual partners (adjusted OR, AOR for 5+ partners, past 5 years, 31.50, 95% CI 18.69 to 53.09). After adjusting for partner numbers, paying for sex remained strongly associated with reporting new foreign partners outside the UK (AOR 7.96; 95% CI 4.97 to 12.73) and STI diagnosis/es (AOR 2.34; 95% CI 1.44 to 3.81), all in the past 5 years. Among men ever paying for sex, 62.6% (95% CI 58.3% to 66.8%) reported paying for sex outside the UK, most often in Europe and Asia. Conclusions MPS in Britain remain at greater risk of STI acquisition and onward transmission than men who do not. They report high numbers of partners, but the minority are paid partners. They are an important core group in STI transmission

Sexual identity, attraction and behaviour in Britain: The implications of using different dimensions of sexual orientation to estimate the size of sexual minority populations and inform public health interventions.

BACKGROUND: Sexual orientation encompasses three dimensions: sexual identity, attraction and behaviour. There is increasing demand for data on sexual orientation to meet equality legislation, monitor potential inequalities and address public health needs. We present estimates of all three dimensions and their overlap in British men and women, and consider the implications for health services, research and the development and evaluation of public health interventions. METHODS: Analyses of data from Britain's third National Survey of Sexual Attitudes and Lifestyles, a probability sample survey (15,162 people aged 16-74 years) undertaken in 2010-2012. FINDINGS: A lesbian, gay or bisexual (LGB) identity was reported by 2·5% of men and 2·4% of women, whilst 6·5% of men and 11·5% of women reported any same-sex attraction and 5·5% of men and 6·1% of women reported ever experience of same-sex sex. This equates to approximately 547,000 men and 546,000 women aged 16-74 in Britain self-identifying as LGB and 1,204,000 men and 1,389,000 women ever having experience of same-sex sex. Of those reporting same-sex sex in the past 5 years, 28% of men and 45% of women identified as heterosexual. INTERPRETATION: There is large variation in the size of sexual minority populations depending on the dimension applied, with implications for the design of epidemiological studies, targeting and monitoring of public health interventions and estimating population-based denominators. There is also substantial diversity on an individual level between identity, behaviour and attraction, adding to the complexity of delivering appropriate services and interventions

Medicated sex in Britain: evidence from the third National Survey of Sexual Attitudes and Lifestyles

Objectives: To describe the prevalence of medication use to assist sexual performance in Britain and to identify associated factors. / Methods: Cross-sectional probability sample, undertaken in 2010–2012, of 15 162 people aged 16–74 years, resident in Britain, of whom, 5617 men and 8095 women reported sexual experience (ever) and 4817 men were sexually-active (reported sex in the last year). / Results: Ever use of medication to assist sexual performance (medicated sex) was more commonly reported by men than women (12.9% (95% CI 11.9% to 13.9%) vs 1.9% (95% CI 1.7% to 2.3%)) and associated with older age in men and younger age in women. It was associated with reporting smoking, and use of alcohol and recreational drugs, as well as unsafe sex (≥2 partners and no condom use in the last year) in both men and women. Among men, the proportion reporting medicated sex in the last year was higher among those reporting erectile difficulties (ED) than those not doing so (28.4% (95% CI 24.4% to 32.8%) vs 4.1% (95% CI 3.4% to 4.9%)). In all men, medicated sex was associated with more frequent sexual activity, meeting a partner on the internet, unsafe sex and recent sexually transmitted infections diagnosis; associations that persisted after adjusting for same-sex behaviour and ED. However, there were significant interactions with reporting ED, indicating that among men with ED, medicated sex is not associated with same-sex behaviour and ever use of recreational drugs. / Conclusions: A substantial minority of people in Britain report medicated sex, and the association between medicated sex and risky sexual behaviour is not confined to high-risk groups