Relationship of hypoxia to metastatic ability in rodent tumours

The relationship between tumour oxygenation in vivo and metastatic potential was investigated in 2 rodent tumour models, KHT-C fibrosarcoma and SCC-VII squamous cell carcinoma. The oxygen status in these rodent tumours transplanted intramuscularly in syngeneic mice was measured using the Eppendorf pO 2 Histograph. The results indicate a considerable heterogeneity in oxygenation between individual tumours within each tumour cell line. At different tumour sizes, animals were killed and lung lobes were examined for macroscopic and microscopic lung metastases. In the KHT-C tumours, a significant increase in early pulmonary metastasis formation was observed in mice with hypoxic primary tumours. Hypoxic SCC-VII tumours did not give rise to enhanced lung metastasis formation despite oxygenation in a range similar to the KHT-C tumours. However, the overall metastasis incidence in the SCC-VII model was very low. The results obtained in the KHT-C model, which show that hypoxic tumours are more likely to metastasize, are in agreement with recent clinical data suggesting that a hypoxic environment might be implicated in metastatic ability of human tumours. © 2001 Cancer Research Campaign http://www.bjcancer.co

Breakdown of self-organized criticality

We introduce two sandpile models which show the same behavior of real sandpiles, that is, an almost self-organized critical behavior for small systems and the dominance of large avalanches as the system size increases. The systems become fully self-organized critical, with the critical exponents of the Bak, Tang and Wiesenfeld model, as the system parameters are changed, showing that these systems can make a bridge between the well known theoretical and numerical results and what is observed in real experiments. We find that a simple mechanism determines the boundary where self-organized can or cannot exist, which is the presence of local chaos.Comment: 3 pages, 4 figure

Rheology of bidisperse non-Brownian suspensions

We study the rheology of bidisperse non-Brownian suspensions using particle-based simulation, mapping the viscosity as a function of the size ratio of the species, their relative abundance, and the overall solid content. The variation of the viscosity with applied stress exhibits paradigmatic shear thickening phenomenology irrespective of composition, though the stress-dependent limiting solids fraction governing the viscosity and its divergence point are non-monotonic in the mixing ratio. Contact force data demonstrate an exchange in dominant stress contribution from large-large to small-small particle contacts as the mixing ratio of the species evolves. Combining a prior model for shear thickening with one for composition-dependent jamming, we obtain a full description of the rheology of bidisperse non-Brownian suspensions capable of predicting effects such as the viscosity reduction observed upon adding small particle fines to a suspension of large particles.Comment: 5 pages, 4 figure

Anomalous Transport in Conical Granular Piles

Experiments on 2+1-dimensional piles of elongated particles are performed. Comparison with previous experiments in 1+1 dimensions shows that the addition of one extra dimension to the dynamics changes completely the avalanche properties, appearing a characteristic avalanche size. Nevertheless, the time single grains need to cross the whole pile varies smoothly between several orders of magnitude, from a few seconds to more than 100 hours. This behavior is described by a power-law distribution, signaling the existence of scale invariance in the transport process.Comment: Accepted in PR

Nearest pattern interaction and global pattern formation

We studied the effect of nearest pattern interaction on a globally pattern formation in a 2-dimensional space, where patterns are to grow initially from a noise in the presence of periodic supply of energy. Although our approach is general, we found that this study is relevant in particular to the pattern formation on a periodically vibrated granular layer, as it gives a unified perspective of the experimentally observed pattern dynamics such as oscillon and stripe formations, skew-varicose and crossroll instabilities, and also a kink formation and decoration

Smoothing of sandpile surfaces after intermittent and continuous avalanches: three models in search of an experiment

We present and analyse in this paper three models of coupled continuum equations all united by a common theme: the intuitive notion that sandpile surfaces are left smoother by the propagation of avalanches across them. Two of these concern smoothing at the `bare' interface, appropriate to intermittent avalanche flow, while one of them models smoothing at the effective surface defined by a cloud of flowing grains across the `bare' interface, which is appropriate to the regime where avalanches flow continuously across the sandpile.Comment: 17 pages and 26 figures. Submitted to Physical Review

Knots and Random Walks in Vibrated Granular Chains

We study experimentally statistical properties of the opening times of knots in vertically vibrated granular chains. Our measurements are in good qualitative and quantitative agreement with a theoretical model involving three random walks interacting via hard core exclusion in one spatial dimension. In particular, the knot survival probability follows a universal scaling function which is independent of the chain length, with a corresponding diffusive characteristic time scale. Both the large-exit-time and the small-exit-time tails of the distribution are suppressed exponentially, and the corresponding decay coefficients are in excellent agreement with the theoretical values.Comment: 4 pages, 5 figure

4/3-Law of Granular Particles Flowing through a Vertical Pipe

Density waves of granular material (sand) flowing through a vertical pipe have been investigated. Clear density waves emerge when the cock attached to bottom end of the pipe is closed. The FFT power spectra were found to show a stable power-law form $P(f) \sim f^{-\alpha}.$ The value of the exponent was evaluated as $\alpha \cong 4/3$. We also introduce a simple one-dimensional model which reproduces $\alpha = 4/3$ from both simulation and theoretical analysis. (to be published in Phys.Rev.Lett.)Comment: 4 pages, 4 figures, a style fil

SN 2016jhj at redshift 0.34: extending the Type II supernova Hubble diagram using the standard candle method

Although Type Ia supernova cosmology has now reached a mature state, it is important to develop as many independent methods as possible to understand the true nature of dark energy. Recent studies have shown that Type II supernovae (SNe II) offer such a path and could be used as alternative distance indicators. However, the majority of these studies were unable to extend the Hubble diagram above redshift z = 0.3 because of observational limitations. Here, we show that we are now ready to move beyond low redshifts and attempt high-redshift (z ≳ 0.3) SN II cosmology as a result of new-generation deep surveys such as the Subaru/Hyper Suprime-Cam survey. Applying the ´standard candle method´ to SN 2016jhj (z = 0.3398 ± 0.0002; discovered by HSC) together with a low-redshift sample, we are able to construct the highest-redshift SN II Hubble diagram to date with an observed dispersion of 0.27 mag (i.e. 12-13 per cent in distance). This work demonstrates the bright future of SN II cosmology in the coming era of large, wide-field surveys like that of the Large Synoptic Survey Telescope.Fil: de Jaeger, T.. University of California at Berkeley; Estados UnidosFil: Galbany, L.. University of Pittsburgh at Johnstown; Estados UnidosFil: Filippenko, A. V.. University of California at Berkeley; Estados UnidosFil: González Gaitán, S.. Universidad de Chile; ChileFil: Yasuda, N.. University of Tokio; JapónFil: Maeda, K.. University of Tokio; JapónFil: Tanaka, M.. University of Tokio; JapónFil: Morokuma, T.. University of Tokio; JapónFil: Moriya, T. J.. National Astronomical Observatory of Japan; JapónFil: Tominaga, N.. University of Tokyo; JapónFil: Nomoto, Ken’ichi. University of Tokyo; JapónFil: Komiyama, Y.. National Astronomical Observatory of Japan; JapónFil: Anderson, J. P.. European Southern Observatory; ChileFil: Brink, T. G.. University of California at Berkeley; Estados UnidosFil: Carlberg, R. G.. University of Toronto; CanadáFil: Folatelli, Gaston. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas; Argentina. University of Tokyo; JapónFil: Hamuy, M.. Universidad de Chile; ChileFil: Pignata, G.. Universidad Andrés Bello; ChileFil: Zheng, W.. University of California at Berkeley; Estados Unido

Applying the volume averaging theory to open-cell metal foam in natural convection/radiation

Papers presented to the 11th International Conference on Heat Transfer, Fluid Mechanics and Thermodynamics, South Africa, 20-23 July 2015.Heat sinks made out of open-cell aluminium foam are investigated numerically in natural convection. Results derived from a 2D numerical model are compared to results for in-house experiments. Different foam heights are studied. The numerical model is based on the volume averaging theory. The aluminium foam that is used has 10 pores per linear inch and a porosity of 93%. The temperature of the substrate was varied between 55°C and 95°C. The geometry used in the numerical model replicates the experimental test rig as well as possible. A discussion of the determination of the closure terms is given. If only convective heat transfer is taken into account in the numerical model, the relative differences between the numerical and experimental results are smaller than 29% for all foam heights studied. However, when the influence of radiation is included in the numerical model, it is shown that the numerical results differ less than 9% with the experimental ones. This validates the choice of closure terms used in the model and this shows that it is necessary to properly model radiative heat transfer in numerical models of open-cell aluminium foam in natural convection.am201