Reduction of salmonella contamination in pork carcasses by vaccination

Two field studies and one laboratory challenge were performed to evaluate of vaccination with a live, avirulent Salmonella choleraesuis vaccine (Enterisol® SC-54) to provide cross protection, reduce the level of internal culture and fecal shedding of multiple serovars of Salmonella. Barns of grow-finish pigs were vaccinated orally, via drinking water, or left as matched controls in the field studies. Ileocecal lymph nodes and spiral colon fecal material were collected at the abattoir from field studies. Three week old pigs were vaccinated intranasally and challenged at five weeks of age in the laboratory study. Internal organ culture and fecal shedding were measured two weeks following challenge with S typhimurium. In all three studies, vaccinated pigs had significantly lower culture prevalence of non S choleraesuis serovars (p\u3c0.05), and reduced fecal shedding in following laboratory challenge (p\u3c0.05). A nominal (p=0.07) trend to improved growth rate following laboratory challenge with S typhimurium challenge was also detected

Reduction of Salmonella choleraesuis contamination in pork carcasses by vaccination

Salmonellosis is a common clinical and subclinical infection of pigs. The species adapted serovar S choleraesuis predominantly produces a septicemic disease in swine. Disease in other species, including humans, is rare compared to enteric type infections from non host adapted serovars such as S typhimurium. However, when host adapted serovars infect alternate species, disease can be severe. Vaccination with an avirulent live S choleraesuis vaccine, Enterisol® SC-54, significantly reduces prevalence and quantity of infection in pigs. Additionally, those pigs that remain culture positive have two logs or more reduction in the quantity of S choleraesuis present. Vaccination of pigs as young as one day of age is successful. Where these infections are of concern in the human population, vaccination of pigs may provide dramatic reductions of the organism swine, reducing risk in food items of swine origin

The sequelae of a missed Essex-Lopresti lesion

Radial head fractures are the most common type of elbow fracture in adults. Unrecognised disruption of the intraosseous membrane at the time of injury can lead to severe wrist pain from proximal radial migration especially if the radial head is excised. In this case, despite anatomical reduction and internal fixation of the radial head fracture, longitudinal forearm instability developed after delayed radial head resection was performed 7 months post-injury. A Suave-Kapandji procedure was performed due to ongoing wrist pain. Because of the previous radial head resection, this led to a floating forearm that could only be solved by creating a one-bone forearm, sacrificing all forearm rotation to achieve a stable lever arm between the elbow and wrist joint

A summary of the ECAS performance and cost results for MHD systems

The potential is examined of various advanced power plant concepts using coal and coal-derived fuel. The results indicate that open cycle coal fired direct preheat MHD systems have potentially one of the highest coal-pile-to-bus-bar efficiencies and also one of the lowest costs of electricity (COE) of the systems studied. Closed cycle MHD systems may have the potential to approach the efficiency and COE of open cycle MHD. The 1200-1500 F liquid metal MHD systems studied do not appear to have the potential of exceeding the efficiency or competing with the COE of advanced steam plants

A pilot hole does not reduce the strains or risk of fracture to the lateral cortex during and following a medial opening wedge high tibial osteotomy in cadaveric specimens

© 2018 Bujnowski et al. Aim: It has been suggested that the use of a pilot-hole may reduce the risk of fracture to the lateral cortex. Therefore the purpose of this study was to determine the effect of a pilot hole on the strains and occurrence of fractures at the lateral cortex during the opening of a high tibial osteotomy (HTO) and post-surgery loading. Materials and Methods: A total of 14 cadaveric tibias were randomized to either a pilot hole (n = 7) or a no-hole (n = 7) condition. Lateral cortex strains were measured while the osteotomy was opened 9 mm and secured in place with a locking plate. The tibias were then subjected to an initial 800 N load that increased by 200 N every 5000 cycles, until failure or a maximum load of 2500 N. Results: There was no significant difference in the strains on the lateral cortex during HTO opening between the pilot hole and no-hole conditions. Similarly, the lateral cortex and fixation plate strains were not significantly different during cyclic loading between the two conditions. Using a pilot hole did not significantly decrease the strains experienced at the lateral cortex, nor did it reduce the risk of fracture. Conclusions: The nonsignificant differences found here most likely occurred because the pilot hole merely translated the stress concentration laterally to a parallel point on the surface of the hole

Conceptual design of the MHD Engineering Test Facility

The reference conceptual design of the MHD engineering test facility, a prototype 200 MWe coal-fired electric generating plant designed to demonstrate the commerical feasibility of open cycle MHD is summarized. Main elements of the design are identified and explained, and the rationale behind them is reviewed. Major systems and plant facilities are listed and discussed. Construction cost and schedule estimates are included and the engineering issues that should be reexamined are identified

Long-term trends of black carbon and sulphate aerosol in the Arctic: changes in atmospheric transport and source region emissions

As a part of the IPY project POLARCAT (Polar Study using Aircraft, Remote Sensing, Surface Measurements and Models, of Climate, Chemistry, Aerosols and Transport) and building on previous work (Hirdman et al., 2010), this paper studies the long-term trends of both atmospheric transport as well as equivalent black carbon (EBC) and sulphate for the three Arctic stations Alert, Barrow and Zeppelin. We find a general downward trend in the measured EBC concentrations at all three stations, with a decrease of −2.1±0.4 ng m<sup>−3</sup> yr<sup>−1</sup> (for the years 1989–2008) and −1.4±0.8 ng m<sup>−3</sup> yr<sup>−1</sup> (2002–2009) at Alert and Zeppelin respectively. The decrease at Barrow is, however, not statistically significant. The measured sulphate concentrations show a decreasing trend at Alert and Zeppelin of −15±3 ng m<sup>−3</sup> yr<sup>−1</sup> (1985–2006) and −1.3±1.2 ng m<sup>−3</sup> yr<sup>−1</sup> (1990–2008) respectively, while there is no trend detectable at Barrow. <br><br> To reveal the contribution of different source regions on these trends, we used a cluster analysis of the output of the Lagrangian particle dispersion model FLEXPART run backward in time from the measurement stations. We have investigated to what extent variations in the atmospheric circulation, expressed as variations in the frequencies of the transport from four source regions with different emission rates, can explain the long-term trends in EBC and sulphate measured at these stations. We find that the long-term trend in the atmospheric circulation can only explain a minor fraction of the overall downward trend seen in the measurements of EBC (0.3–7.2%) and sulphate (0.3–5.3%) at the Arctic stations. The changes in emissions are dominant in explaining the trends. We find that the highest EBC and sulphate concentrations are associated with transport from Northern Eurasia and decreasing emissions in this region drive the downward trends. Northern Eurasia (cluster: NE, WNE and ENE) is the dominant emission source at all Arctic stations for both EBC and sulphate during most seasons. In wintertime, there are indications that the EBC emissions from the eastern parts of Northern Eurasia (ENE cluster) have increased over the last decade

Compact, Intelligent, Digitally Controlled IGBT Gate Drivers for a PEBB-Based ILC Marx Modulator

SLAC National Accelerator Laboratory has built and is currently operating a first generation prototype Marx klystron modulator to meet ILC specifications. Under development is a second generation prototype, aimed at improving overall performance, serviceability, and manufacturability as compared to its predecessor. It is designed around 32 cells, each operating at 3.75 kV and correcting for its own capacitor droop. Due to the uniqueness of this application, high voltage gate drivers needed to be developed for the main 6.5 kV and droop correction 1.7 kV IGBTs. The gate driver provides vital functions such as protection of the IGBT from over-voltage and over-current, detection of gate-emitter open and short circuit conditions, and monitoring of IGBT degradation (based on collector-emitter saturation voltage). Gate drive control, diagnostic processing capabilities, and communication are digitally implemented using an FPGA. This paper details the design of the gate driver circuitry, component selection, and construction layout. In addition, experimental results are included to illustrate the effectiveness of the protection circuit

The influence of regional circulation patterns on wet and dry mineral dust and sea salt deposition over Greenland

Annually resolved ice core records from different regions over the Greenland ice sheet (GrIS) are used to investigate the spatial and temporal variability of calcium (Ca2+, mainly from mineral dust) and sodium (Na+, mainly from sea salt) deposition. Cores of high common inter-annual variability are grouped with an EOF analysis, resulting in regionally representative Ca2+ and Na+ records for northeastern and central Greenland. Utilizing a regression and validation method with ERA-40 reanalysis data, these common records are associated with distinct regional atmospheric circulation patterns over the North American Arctic, Greenland, and Central to Northern Europe. These patterns are interpreted in terms of transport and deposition of the impurities. In the northeastern part of the GrIS sea salt records reflect the intrusion of marine air masses from southeasterly flow. A large fraction of the Ca2+ variability in this region is connected to a circulation pattern suggesting transport from the west and dry deposition. This pattern is consistent with the current understanding of a predominantly Asian source of the dust deposited over the GrIS. However, our results also indicate that a significant fraction of the inter-annual dust variability in NE and Central Greenland is determined by the frequency and intensity of wet deposition during the season of high atmospheric dust loading, rather than representing the variability of the Asian dust source and/or long-range transport to Greenland. The variances in the regional proxy records explained by the streamfunction patterns are high enough to permit reconstructions of the corresponding regional deposition regimes and the associated circulation pattern