Simulating a White Dwarf-dominated Galactic Halo

Observational evidence has suggested the possibility of a Galactic halo which is dominated by white dwarfs (WDs). While debate continues concerning the interpretation of this evidence, it is clear that an initial mass function (IMF) biased heavily toward WD precursors (1 < m/Msol < 8), at least in the early Universe, would be necessary in generating such a halo. Within the framework of homogeneous, closed-box models of Galaxy formation, such biased IMFs lead to an unavoidable overproduction of carbon and nitrogen relative to oxygen (as measured against the abundance patterns in the oldest stars of the Milky Way). Using a three-dimensional Tree N-body smoothed particle hydrodynamics code, we study the dynamics and chemical evolution of a galaxy with different IMFs. Both invariant and metallicity-dependent IMFs are considered. Our variable IMF model invokes a WD-precursor-dominated IMF for metallicities less than 5% solar (primarily the Galactic halo), and the canonical Salpeter IMF otherwise (primarily the disk). Halo WD density distributions and C,N/O abundance patterns are presented. While Galactic haloes comprised of ~5% (by mass) of WDs are not supported by our simulations, mass fractions of ~1-2% cannot be ruled out. This conclusion is consistent with the present-day observational constraints.Comment: accepted for publication in MNRA

Why Don\u27t They Play with Me

https://digitalcommons.library.umaine.edu/mmb-vp/2967/thumbnail.jp

Low frequency elastic wave propagation in 2D locally resonant phononic crystal with asymmetric resonator

The resonance modes and the related effects to the transmission of elastic waves in a two dimensional phononic crystal formed by periodic arrangements of a two blocks unit cell in one direction are studied. The unit cell consists of two asymmetric elliptic cylinders coated with silicon rubber and embedded in a rigid matrix. The modes are obtained by the semi-analytic method in the least square collocation scheme and confirmed by the finite element method simulations. Two resonance modes, corresponding to the vibration of the cylinder along the long and short axes, give rise to resonance reflections of elastic waves. One mode in between the two modes, related to the opposite vibration of the two cylinders in the unit cell in the direction along the layer, results in the total transmission of elastic waves due to zero effective mass density at the frequency. The resonance frequency of this new mode changes continuously with the orientation angle of the elliptic resonator.Comment: 17 pages, 7 figure

Thrombospondin-1-Mediated Metastasis Suppression by the Primary Tumor in Human Melanoma Xenografts

Some cancer patients show accelerated growth of pre-existing metastases after removal of the primary tumor. The purpose of this study was to investigate whether primary tumor-induced metastasis suppression can be mediated by thrombospondin-1 in melanoma. Human melanoma xenografts (D-12, R-18, and U-25) were used as models of melanoma in humans. Melanoma angiogenesis, lung colonization, and spontaneous pulmonary metastasis were inhibited in mice bearing D-12, U-25, or thrombospondin-1 overexpressing R-18 tumors, which showed high thrombospondin-1 expression and secreted large quantities of thrombospondin-1 into the blood, but not in mice bearing wild-type R-18 tumors, which were negative for thrombospondin-1. D-12 tumors suppressed the growth of their own spontaneous metastases. The anti-angiogenic and anti-metastatic effects of D-12 and U-25 tumors were blocked in mice treated with thrombospondin-1 neutralizing antibody. Dormant avascular microcolonies having an elevated apoptotic activity were seen in the lungs of mice bearing D-12 or U-25 tumors, whereas only neovascularized lung macrocolonies were seen in control and antibody-treated mice. This study suggests that some melanoma patients may benefit from combined local treatment and long-term anti-angiogenic therapy involving thrombospondin-1

Self-similar impulsive capillary waves on a ligament

We study the short-time dynamics of a liquid ligament, held between two solid cylinders, when one is impulsively accelerated along its axis. A set of one-dimensional equations in the slender-slope approximation is used to describe the dynamics, including surface tension and viscous effects. An exact self-similar solution to the linearized equations is successfully compared to experiments made with millimetric ligaments. Another non-linear self-similar solution of the full set of equations is found numerically. Both the linear and non-linear solutions show that the axial depth at which the liquid is affected by the motion of the cylinder scales like $\sqrt{t}$. The non-linear solution presents the peculiar feature that there exists a maximum driving velocity $U^\star$ above which the solution disappears, a phenomenon probably related to the de-pinning of the contact line observed in experiments for large pulling velocities

Responsibility without legal authority? Tackling alcohol-related health harms through licensing and planning policy in local government.

BACKGROUND: The power to influence many social determinants of health lies within local government sectors that are outside public health's traditional remit. We analyse the challenges of achieving health gains through local government alcohol control policies, where legal and professional practice frameworks appear to conflict with public health action. METHODS: Current legislation governing local alcohol control in England and Wales is reviewed and analysed for barriers and opportunities to implement effective population-level health interventions. Case studies of local government alcohol control practices are described. RESULTS: Addressing alcohol-related health harms is constrained by the absence of a specific legal health licensing objective and differences between public health and legal assessments of the relevance of health evidence to a specific place. Local governments can, however, implement health-relevant policies by developing local evidence for alcohol-related health harms; addressing cumulative impact in licensing policy statements and through other non-legislative approaches such as health and non-health sector partnerships. Innovative local initiatives-for example, minimum unit pricing licensing conditions-can serve as test cases for wider national implementation. CONCLUSIONS: By combining the powers available to the many local government sectors involved in alcohol control, alcohol-related health and social harms can be tackled through existing local mechanisms