Patients with low back pain differ from those who also have leg pain or signs of nerve root involvement - A cross-sectional study

Background: Leg pain associated with low back pain (LBP) is recognized as a risk factor for a poor prognosis, and is included as a component in most LBP classification systems. The location of leg pain relative to the knee and the presence of a positive straight leg raise test have been suggested to have clinical implications. To understand differences between such leg pain subgroups, and whether differences include potentially modifiable characteristics, the purpose of this paper was to describe characteristics of patients classified into the Quebec Task Force (QTF) subgroups of: 1) LBP only, 2) LBP and pain above the knee, 3) LBP and pain below the knee, and 4) LBP and signs of nerve root involvement. Methods. Analysis of routine clinical data from an outpatient department. Based on patient reported data and clinical findings, patients were allocated to the QTF subgroups and described according to the domains of pain, activity limitation, work participation, psychology, general health and clinical examination findings. Results: A total of 2,673 patients aged 18-95 years (median 47) who were referred for assessment of LBP were included. Increasing severity was consistently observed across the subgroups from LBP only to LBP with signs of nerve root involvement although subgroup differences were small. LBP patients with leg pain differed from those with LBP only on a wide variety of parameters, and patients with signs of nerve root involvement had a more severe profile on almost all measures compared with other patients with back-related leg pain. Conclusion: LBP patients with pain referral to the legs were more severely affected than those with local LBP, and patients with signs of nerve root involvement were the ones most severily affected. These findings underpin the concurrent validity of the Quebec Task Force Classification. However, the small size of many between-subgroup differences amid the large variability in this sample of cross-sectional data also underlines that the heterogeneity of patients with LBP is more complex than that which can be explained by leg pain patterns alone. The implications of the observed differences also require investigation in longitudinal studies

SHADOWS (Search for Hidden And Dark Objects With the SPS):Letter of Intent

We propose a new proton beam-dump experiment, SHADOWS, to search for a large variety of feebly-interacting particles possibly produced in the interactions of a 400 GeV proton beam with a high-Z material dump. SHADOWS will use the 400 GeV primary proton beam extracted from the CERN SPS currently serving the NA62 experiment in the CERN North area. SHADOWS will take data off-axis concurrently to the HIKE experiment when the P42 beam line is operated in beam-dump mode to accumulate up to 5 · 10^19 protons on target in 4 years of operation. This document describes the main achievements with respect to the Expression of Interest and represents an intermediate step towards the Proposal

A bio-psycho-social exercise program (RÜCKGEWINN) for chronic low back pain in rehabilitation aftercare - Study protocol for a randomised controlled trial

<p>Abstract</p> <p>Background</p> <p>There is strong, internationally confirmed evidence for the short-term effectiveness of multimodal interdisciplinary specific treatment programs for chronic back pain. However, the verification of long-term sustainability of achieved effects is missing so far. For long-term improvement of pain and functional ability high intervention intensity or high volume seems to be necessary (> 100 therapy hours). Especially in chronic back pain rehabilitation, purposefully refined aftercare treatments offer the possibility to intensify positive effects or to increase their sustainability. However, quality assured goal-conscious specific aftercare programs for the rehabilitation of chronic back pain are absent.</p> <p>Methods/Design</p> <p>This study aims to examine the efficacy of a specially developed bio-psycho-social chronic back pain specific aftercare intervention (RÜCKGEWINN) in comparison to the current usual aftercare (IRENA) and a control group that is given an educational booklet addressing pain-conditioned functional ability and back pain episodes. Overall rehabilitation effects as well as predictors for compliance to the aftercare programs are analysed. Therefore, a multicenter prospective 3-armed randomised controlled trial is conducted. 456 participants will be consecutively enrolled in inpatient and outpatient rehabilitation and assigned to either one of the three study arms. Outcomes are measured before and after rehabilitation. Aftercare programs are assessed at ten month follow up after dismissal form rehabilitation.</p> <p>Discussion</p> <p>Special methodological and logistic challenges are to be mastered in this trial, which accrue from the interconnection of aftercare interventions to their residential district and the fact that the proportion of patients who take part in aftercare programs is low. The usability of the aftercare program is based on the transference into the routine care and is also reinforced by developed manuals with structured contents, media and material for organisation assistance as well as training manuals for therapists in the aftercare.</p> <p>Trial Registration</p> <p>Trial Registration number: NCT01070849</p

KLEVER: An experiment to measure BR(KL→π0ννˉK_L\to\pi^0\nu\bar{\nu}) at the CERN SPS

Precise measurements of the branching ratios for the flavor-changing neutral current decays $K\to\pi\nu\bar{\nu}$ can provide unique constraints on CKM unitarity and, potentially, evidence for new physics. It is important to measure both decay modes, $K^+\to\pi^+\nu\bar{\nu}$ and $K_L\to\pi^0\nu\bar{\nu}$, since different new physics models affect the rates for each channel differently. The goal of the NA62 experiment at the CERN SPS is to measure the BR for the charged channel to within 10%. For the neutral channel, the BR has never been measured. We are designing the KLEVER experiment to measure BR($K_L\to\pi^0\nu\bar{\nu}$) to $\sim$20% using a high-energy neutral beam at the CERN SPS starting in LHC Run 4. The boost from the high-energy beam facilitates the rejection of background channels such as $K_L\to\pi^0\pi^0$ by detection of the additional photons in the final state. On the other hand, the layout poses particular challenges for the design of the small-angle vetoes, which must reject photons from $K_L$ decays escaping through the beam exit amidst an intense background from soft photons and neutrons in the beam. Background from $\Lambda \to n\pi^0$ decays in the beam must also be kept under control. We present findings from our design studies for the beamline and experiment, with an emphasis on the challenges faced and the potential sensitivity for the measurement of BR($K_L\to\pi^0\nu\bar{\nu}$).Comment: 13 pages, 4 figures. Submitted as input to the 2020 update of the European Strategy for Particle Physics. v2: Included authors unintentionally omitted in v

SND@LHC: The Scattering and Neutrino Detector at the LHC

SND@LHC is a compact and stand-alone experiment designed to perform measurements with neutrinos produced at the LHC in the pseudo-rapidity region of ${7.2 < \eta < 8.4}$. The experiment is located 480 m downstream of the ATLAS interaction point, in the TI18 tunnel. The detector is composed of a hybrid system based on an 830 kg target made of tungsten plates, interleaved with emulsion and electronic trackers, also acting as an electromagnetic calorimeter, and followed by a hadronic calorimeter and a muon identification system. The detector is able to distinguish interactions of all three neutrino flavours, which allows probing the physics of heavy flavour production at the LHC in the very forward region. This region is of particular interest for future circular colliders and for very high energy astrophysical neutrino experiments. The detector is also able to search for the scattering of Feebly Interacting Particles. In its first phase, the detector will operate throughout LHC Run 3 and collect a total of 250 $\text{fb}^{-1}$